Clinical Quantitative Electromyography

No abstract available

Real-time human ambulation, activity, and physiological monitoring:taxonomy of issues, techniques, applications, challenges and limitations

Automated methods of real-time, unobtrusive, human ambulation, activity, and wellness monitoring and data analysis using various algorithmic techniques have been subjects of intense research. The general aim is to devise effective means of addressing the demands of assisted living, rehabilitation, and clinical observation and assessment through sensor-based monitoring. The research studies have resulted in a large amount of literature. This paper presents a holistic articulation of the research studies and offers comprehensive insights along four main axes: distribution of existing studies; monitoring device framework and sensor types; data collection, processing and analysis; and applications, limitations and challenges. The aim is to present a systematic and most complete study of literature in the area in order to identify research gaps and prioritize future research directions

Hierarchical Classification and its Application in University Search

Web search engines have been adopted by most universities for searching webpages in their own domains. Basically, a user sends keywords to the search engine and the search engine returns a flat ranked list of webpages. However, in university search, user queries are usually related to topics. Simple keyword queries are often insufficient to express topics as keywords. On the other hand, most E-commerce sites allow users to browse and search products in various hierarchies. It would be ideal if hierarchical browsing and keyword search can be seamlessly combined for university search engines. The main difficulty is to automatically classify and rank a massive number of webpages into the topic hierarchies for universities. In this thesis, we use machine learning and data mining techniques to build a novel hybrid search engine with integrated hierarchies for universities, called SEEU (Search Engine with hiErarchy for Universities). Firstly, we study the problem of effective hierarchical webpage classification. We develop a parallel webpage classification system based on Support Vector Machines. With extensive experiments on the well-known ODP (Open Directory Project) dataset, we empirically demonstrate that our hierarchical classification system is very effective and outperforms the traditional flat classification approaches significantly. Secondly, we study the problem of integrating hierarchical classification into the ranking system of keywords-based search engines. We propose a novel ranking framework, called ERIC (Enhanced Ranking by hIerarchical Classification), for search engines with hierarchies. Experimental results on four large-scale TREC (Text REtrieval Conference) web search datasets show that our ranking system with hierarchical classification outperforms the traditional flat keywords-based search methods significantly. Thirdly, we propose a novel active learning framework to improve the performance of hierarchical classification, which is important for ranking webpages in hierarchies. From our experiments on the benchmark text datasets, we find that our active learning framework can achieve good classification performance yet save a considerable number of labeling effort compared with the state-of-the-art active learning methods for hierarchical text classification. Fourthly, based on the proposed classification and ranking methods, we present a novel hierarchical classification framework for mining academic topics from university webpages. We build an academic topic hierarchy based on the commonly accepted Wikipedia academic disciplines. Based on this hierarchy, we train a hierarchical classifier and apply it to mine academic topics. According to our comprehensive analysis, the academic topics mined by our method are reasonable and consistent with the real-world topic distribution in universities. Finally, we combine all the proposed techniques together and implement the SEEU search engine. According to two usability studies conducted in the ECE and the CS departments at our university, SEEU is favored by the majority of participants. To conclude, the main contribution of this thesis is a novel search engine, called SEEU, for universities. We discuss the challenges toward building SEEU and propose effective machine learning and data mining methods to tackle them. With extensive experiments on well-known benchmark datasets and real-world university webpage datasets, we demonstrate that our system is very effective. In addition, two usability studies of SEEU in our university show that SEEU has a great promise for university search

On the Recognition of Emotion from Physiological Data

This work encompasses several objectives, but is primarily concerned with an experiment where 33 participants were shown 32 slides in order to create ‗weakly induced emotions‘. Recordings of the participants‘ physiological state were taken as well as a self report of their emotional state. We then used an assortment of classifiers to predict emotional state from the recorded physiological signals, a process known as Physiological Pattern Recognition (PPR). We investigated techniques for recording, processing and extracting features from six different physiological signals: Electrocardiogram (ECG), Blood Volume Pulse (BVP), Galvanic Skin Response (GSR), Electromyography (EMG), for the corrugator muscle, skin temperature for the finger and respiratory rate. Improvements to the state of PPR emotion detection were made by allowing for 9 different weakly induced emotional states to be detected at nearly 65% accuracy. This is an improvement in the number of states readily detectable. The work presents many investigations into numerical feature extraction from physiological signals and has a chapter dedicated to collating and trialing facial electromyography techniques. There is also a hardware device we created to collect participant self reported emotional states which showed several improvements to experimental procedure

Bioinformatics approaches for the analysis of lipidomics data

The potential impact of lipid research has been increasingly realised both in disease treatment and prevention. Recent advances in soft ionization mass spectrometry (MS) such as electrospray ionization (ESI) have permitted parallel monitoring of several hundreds of lipids in a single experiment and thus facilitated lipidomics level studies. These advances, however, pose a greater challenge for bioinformaticians to handle massive amounts of information-rich MS data from modern analytical instruments in order to understand complex functions of lipids. The main aims of this thesis were to 1) develop bioinformatics approaches for lipid identification based on ultra performance liquid chromatography coupled to mass spectrometry (UPLC/MS) data, 2) predict the functional annotations for unidentified lipids, 3) understand the omics data in the context of pathways and 4) apply existing chemometric methods for exploratory data analysis as well as biomarker discovery. A bioinformatics strategy for the construction of lipid database for major classes of lipids is presented using simplified molecular input line entry system (SMILES) approach. The database was annotated with relevant information such as lipid names including short names, SMILES information, scores, molecular weight, monoisotopic mass, and isotope distribution. The database was tailored for UPLC/MS experiments by incorporating the information such as retention time range, adduct information and main fragments to screen for the potential lipids. This database information facilitated building experimental tandem mass spectrometry libraries for different biological tissues. Non-targeted metabolomics screening is often get plagued by the presence of unknown peaks and thus present an additional challenge for data interpretation. Multiple supervised classification methods were employed and compared for the functional prediction of class labels for unidentified lipids to facilitate exploratory analysis further as well as ease the identification process. As lipidomics goes beyond complete characterization of lipids, new strategies were developed to understand lipids in the context of pathways and thereby providing insights for the phenotype characterization. Chemometric methods such as principal component analysis (PCA) and partial least squares and discriminant analysis (PLS/DA) were utilised for exploratory analysis as well as biomarker discovery in the context of different disease phenotypes

Doctor of Philosophy

dissertationNanoinformatics is a relatively young field of study that is important due to its implications in the field of nanomedicine, specifically toward the development of nanoparticle drug delivery systems. As more structural, biochemical, and physiochemical data become available regarding nanoparticles, the greater the knowledge-gain from using nanoinformatics methods will become. While there are challenges that exist with nanoparticle data, including heterogeneity of data and complexity of the particles, nanoinformatics will be at the forefront of processing these data and aid in the design of nanoparticles for biomedical applications. In this dissertation, a review of data mining and machine learning studies performed in the field of nanomedicine is presented. Next, the use of natural language processing methods to extract numeric values of biomedical property terms of poly(amido amine) (PAMAM) dendrimers from nanomedicine literature is demonstrated, along with successful extraction results. Following this is an implementation and its results of data mining techniques used for the development of predictive models of cytotoxicity of PAMAM dendrimers using their chemical and structural properties. Finally, a method and its results for using molecular dynamics simulations to test the ability of EDTA, as a gold standard, and generation 3.5 (G3.5) PAMAM dendrimers to chelate calcium

INTEGRATION OF INTERNET OF THINGS AND HEALTH RECOMMENDER SYSTEMS

The Internet of Things (IoT) has become a part of our lives and has provided many enhancements to day-to-day living. In this project, IoT in healthcare is reviewed. IoT-based healthcare is utilized in remote health monitoring, observing chronic diseases, individual fitness programs, helping the elderly, and many other healthcare fields. There are three main architectures of smart IoT healthcare: Three-Layer Architecture, Service-Oriented Based Architecture (SoA), and The Middleware-Based IoT Architecture. Depending on the required services, different IoT architecture are being used. In addition, IoT healthcare services, IoT healthcare service enablers, IoT healthcare applications, and IoT healthcare services focusing on Smartwatch are presented in this research. Along with IoT in smart healthcare, Health Recommender Systems integration with IoT is important. Main Recommender Systems including Content-based filtering, Collaborative-based filtering, Knowledge-based filtering, and Hybrid filtering with machine learning algorithms are described for the Health Recommender Systems. In this study, a framework is presented for the IoT-based Health Recommender Systems. Also, a case is investigated on how different algorithms can be used for Recommender Systems and their accuracy levels are presented. Such a framework can help with the health issues, for example, risk of going to see the doctor during pandemic, taking quick actions in any health emergencies, affordability of healthcare services, and enhancing the personal lifestyle using recommendations in non-critical conditions. The proposed framework can necessitate further development of IoT-based Health Recommender Systems so that people can mitigate their medical emergencies and live a healthy life

A review of the role of sensors in mobile context-aware recommendation systems

Recommendation systems are specialized in offering suggestions about specific items of different types (e.g., books, movies, restaurants, and hotels) that could be interesting for the user. They have attracted considerable research attention due to their benefits and also their commercial interest. Particularly, in recent years, the concept of context-aware recommendation system has appeared to emphasize the importance of considering the context of the situations in which the user is involved in order to provide more accurate recommendations. The detection of the context requires the use of sensors of different types, which measure different context variables. Despite the relevant role played by sensors in the development of context-aware recommendation systems, sensors and recommendation approaches are two fields usually studied independently. In this paper, we provide a survey on the use of sensors for recommendation systems. Our contribution can be seen from a double perspective. On the one hand, we overview existing techniques used to detect context factors that could be relevant for recommendation. On the other hand, we illustrate the interest of sensors by considering different recommendation use cases and scenarios

Gait Analysis with Wearables Can Accurately Classify Fallers from Non-Fallers:A Step toward Better Management of Neurological Disorders

Falls are the leading cause of mortality, morbidity and poor quality of life in older adults with or without neurological conditions. Applying machine learning (ML) models to gait analysis outcomes offers the opportunity to identify individuals at risk of future falls. The aim of this study was to determine the effect of different data pre-processing methods on the performance of ML models to classify neurological patients who have fallen from those who have not for future fall risk assessment. Gait was assessed using wearables in clinic while walking 20 m at a self-selected comfortable pace in 349 (159 fallers, 190 non-fallers) neurological patients. Six different ML models were trained on data pre-processed with three techniques such as standardisation, principal component analysis (PCA) and path signature method. Fallers walked more slowly, with shorter strides and longer stride duration compared to non-fallers. Overall, model accuracy ranged between 48% and 98% with 43-99% sensitivity and 48-98% specificity. A random forest (RF) classifier trained on data pre-processed with the path signature method gave optimal classification accuracy of 98% with 99% sensitivity and 98% specificity. Data pre-processing directly influences the accuracy of ML models for the accurate classification of fallers. Using gait analysis with trained ML models can act as a tool for the proactive assessment of fall risk and support clinical decision-making