10,215 research outputs found
The link between SARS-CoV-2 related microglial reactivity and astrocyte pathology in the inferior olivary nucleus
The pathological involvement of the central nervous system in SARS-CoV2 (COVID-19) patients is established. The burden of pathology is most pronounced in the brain stem including the medulla oblongata. Hypoxic/ischemic damage is the most frequent neuropathologic abnormality. Other neuropathologic features include neuronophagia, microglial nodules, and hallmarks of neurodegenerative diseases: astrogliosis and microglial reactivity. It is still unknown if these pathologies are secondary to hypoxia versus a combination of inflammatory response combined with hypoxia. It is also unknown how astrocytes react to neuroinflammation in COVID-19, especially considering evidence supporting the neurotoxicity of certain astrocytic phenotypes. This study aims to define the link between astrocytic and microglial pathology in COVID-19 victims in the inferior olivary nucleus, which is one of the most severely affected brain regions in COVID-19, and establish whether COVID-19 pathology is driven by hypoxic damage. Here, we conducted neuropathologic assessments and multiplex-immunofluorescence studies on the medulla oblongata of 18 COVID-19, 10 pre-pandemic patients who died of acute respiratory distress syndrome (ARDS), and 7–8 control patients with no ARDS or COVID-19. The comparison of ARDS and COVID-19 allows us to identify whether the pathology in COVID-19 can be explained by hypoxia alone, which is common to both conditions. Our results showed increased olivary astrogliosis in ARDS and COVID-19. However, microglial density and microglial reactivity were increased only in COVID-19, in a region-specific manner. Also, olivary hilar astrocytes increased YKL-40 (CHI3L1) in COVID-19, but to a lesser extent than ARDS astrocytes. COVID-19 astrocytes also showed lower levels of Aquaporin-4 (AQP4), and Metallothionein-3 in subsets of COVID-19 brain regions. Cluster analysis on immunohistochemical attributes of astrocytes and microglia identified ARDS and COVID-19 clusters with correlations to clinical history and disease course. Our results indicate that olivary glial pathology and neuroinflammation in the COVID-19 cannot be explained solely by hypoxia and suggest that failure of astrocytes to upregulate the anti-inflammatory YKL-40 may contribute to the neuroinflammation. Notwithstanding the limitations of retrospective studies in establishing causality, our experimental design cannot adequately control for factors external to our design. Perturbative studies are needed to confirm the role of the above-described astrocytic phenotypes in neuroinflammation
Machine learning in solar physics
The application of machine learning in solar physics has the potential to
greatly enhance our understanding of the complex processes that take place in
the atmosphere of the Sun. By using techniques such as deep learning, we are
now in the position to analyze large amounts of data from solar observations
and identify patterns and trends that may not have been apparent using
traditional methods. This can help us improve our understanding of explosive
events like solar flares, which can have a strong effect on the Earth
environment. Predicting hazardous events on Earth becomes crucial for our
technological society. Machine learning can also improve our understanding of
the inner workings of the sun itself by allowing us to go deeper into the data
and to propose more complex models to explain them. Additionally, the use of
machine learning can help to automate the analysis of solar data, reducing the
need for manual labor and increasing the efficiency of research in this field.Comment: 100 pages, 13 figures, 286 references, accepted for publication as a
Living Review in Solar Physics (LRSP
Characterizing the surge behaviour and associated ice-dammed lake evolution of the Kyagar Glacier in the Karakoram
Glacier surges are prevalent in the Karakoram and
occasionally threaten local residents by inundating land and initiating mass
movement events. The Kyagar Glacier is well known for its surge history, and
in particular its frequent blocking of the downstream valley, leading to a
series of high-magnitude glacial lake outburst floods (GLOFs). Although the surge
dynamics of the Kyagar Glacier have been broadly described in the
literature, there remains an extensive archive of remote sensing
observations that have great potential for revealing specific surge
characteristics and their relationship with historic lake outburst floods.
In this study, we propose a new perspective on quantifying the surging
process using successive digital elevation models (DEMs), which could be
applied to other sites where glacier surges are known to occur. Advanced
Spaceborne Thermal Emission and Reflection Radiometer DEMs, High Mountain
Asia 8-meter DEMs, and the Shuttle Radar Topography Mission DEM were used to
characterize surface elevation changes throughout the period from 2000 to
2021. We also used Landsat time series imagery to quantify glacier surface
velocities and associated lake changes over the course of two surge events
between 1989 and 2021. Using these datasets, we reconstruct the surging
process of the Kyagar Glacier in unprecedented detail and find a clear signal of
surface uplift over the lower glacier tongue, along with uniformly
increasing velocities, associated with the period of surge initiation.
Seasonal variations in surface flow are still evident throughout the surge
phase, indicating the presence of water at the glacier bed. Surge activity of the
Kyagar Glacier is strongly related to the development and drainage of the
terminal ice-dammed lake, which itself is controlled by the drainage system
beneath the glacier terminus.</p
VIRD: Immersive Match Video Analysis for High-Performance Badminton Coaching
Badminton is a fast-paced sport that requires a strategic combination of
spatial, temporal, and technical tactics. To gain a competitive edge at
high-level competitions, badminton professionals frequently analyze match
videos to gain insights and develop game strategies. However, the current
process for analyzing matches is time-consuming and relies heavily on manual
note-taking, due to the lack of automatic data collection and appropriate
visualization tools. As a result, there is a gap in effectively analyzing
matches and communicating insights among badminton coaches and players. This
work proposes an end-to-end immersive match analysis pipeline designed in close
collaboration with badminton professionals, including Olympic and national
coaches and players. We present VIRD, a VR Bird (i.e., shuttle) immersive
analysis tool, that supports interactive badminton game analysis in an
immersive environment based on 3D reconstructed game views of the match video.
We propose a top-down analytic workflow that allows users to seamlessly move
from a high-level match overview to a detailed game view of individual rallies
and shots, using situated 3D visualizations and video. We collect 3D spatial
and dynamic shot data and player poses with computer vision models and
visualize them in VR. Through immersive visualizations, coaches can
interactively analyze situated spatial data (player positions, poses, and shot
trajectories) with flexible viewpoints while navigating between shots and
rallies effectively with embodied interaction. We evaluated the usefulness of
VIRD with Olympic and national-level coaches and players in real matches.
Results show that immersive analytics supports effective badminton match
analysis with reduced context-switching costs and enhances spatial
understanding with a high sense of presence.Comment: To Appear in IEEE Transactions on Visualization and Computer Graphics
(IEEE VIS), 202
Space‐Scale Resolved Surface Fluxes Across a Heterogeneous, Mid‐Latitude Forested Landscape
The Earth\u27s surface is heterogeneous at multiple scales owing to spatial variability in various properties. The atmospheric responses to these heterogeneities through fluxes of energy, water, carbon, and other scalars are scale-dependent and nonlinear. Although these exchanges can be measured using the eddy covariance technique, widely used tower-based measurement approaches suffer from spectral losses in lower frequencies when using typical averaging times. However, spatially resolved measurements such as airborne eddy covariance measurements can detect such larger scale (meso-β, meso-γ) transport. To evaluate the prevalence and magnitude of these flux contributions, we applied wavelet analysis to airborne flux measurements over a heterogeneous mid-latitude forested landscape, interspersed with open water bodies and wetlands. The measurements were made during the Chequamegon Heterogeneous Ecosystem Energy-balance Study Enabled by a High-density Extensive Array of Detectors intensive field campaign. We ask, how do spatial scales of surface-atmosphere fluxes vary over heterogeneous surfaces across the day and across seasons? Measured fluxes were separated into smaller-scale turbulent and larger-scale mesoscale contributions. We found significant mesoscale contributions to sensible and latent heat fluxes through summer to autumn which would not be resolved in single-point tower measurements through traditional time-domain half-hourly Reynolds decomposition. We report scale-resolved flux transitions associated with seasonal and diurnal changes of the heterogeneous study domain. This study adds to our understanding of surface-atmospheric interactions over unstructured heterogeneities and can help inform multi-scale model-data integration of weather and climate models at a sub-grid scale
Customer Segmentation: An application to dental medicine patients
Internship Report presented as the partial requirement for obtaining a Master's degree in Data Science and Advanced Analytics, specialization in Data ScienceCustomer segmentation allows to divide a company’s customers into multiple market segments, enabling the development of customized marketing actions based on each segment’s characteristics. This work describes the application of a customer segmentation approach to the patients of a Portuguese dental company. The approach taken to select the feature subset for the final model was mostly based on the LRFM (length, recency, frequency, and monetary) model, and the monetary variable was split into multiple variables according to the treatment category where the amount was spent. K-Means and Self-organizing maps were used to cluster the company’s patients using these variables, and the results returned by both algorithms are compared. The final solution was obtained with K-Means, and 7 clusters of patients were identified. An overview of the 7 clusters is provided, and possible marketing actions are suggested based on their main characteristics. The results allowed the company to understand how its turnover was distributed across segments, and to develop an initiative to contact the patients belonging to a segment where most of them did not have an appointment in one of the company’s clinics for a long time
Endogenous measures for contextualising large-scale social phenomena: a corpus-based method for mediated public discourse
This work presents an interdisciplinary methodology for developing endogenous measures of group membership through analysis of pervasive linguistic patterns in public discourse. Focusing on political discourse, this work critiques the conventional approach to the study of political participation, which is premised on decontextualised, exogenous measures to characterise groups. Considering the theoretical and empirical weaknesses of decontextualised approaches to large-scale social phenomena, this work suggests that contextualisation using endogenous measures might provide a complementary perspective to mitigate such weaknesses.
This work develops a sociomaterial perspective on political participation in mediated discourse as affiliatory action performed through language. While the affiliatory function of language is often performed consciously (such as statements of identity), this work is concerned with unconscious features (such as patterns in lexis and grammar). This work argues that pervasive patterns in such features that emerge through socialisation are resistant to change and manipulation, and thus might serve as endogenous measures of sociopolitical contexts, and thus of groups.
In terms of method, the work takes a corpus-based approach to the analysis of data from the Twitter messaging service whereby patterns in users’ speech are examined statistically in order to trace potential community membership. The method is applied in the US state of Michigan during the second half of 2018—6 November having been the date of midterm (i.e. non-Presidential) elections in the United States. The corpus is assembled from the original posts of 5,889 users, who are nominally geolocalised to 417 municipalities. These users are clustered according to pervasive language features. Comparing the linguistic clusters according to the municipalities they represent finds that there are regular sociodemographic differentials across clusters. This is understood as an indication of social structure, suggesting that endogenous measures derived from pervasive patterns in language may indeed offer a complementary, contextualised perspective on large-scale social phenomena
Leveraging a machine learning based predictive framework to study brain-phenotype relationships
An immense collective effort has been put towards the development of methods forquantifying brain activity and structure. In parallel, a similar effort has focused on collecting experimental data, resulting in ever-growing data banks of complex human in vivo neuroimaging data. Machine learning, a broad set of powerful and effective tools for identifying multivariate relationships in high-dimensional problem spaces, has proven to be a promising approach toward better understanding the relationships between the brain and different phenotypes of interest. However, applied machine learning within a predictive framework for the study of neuroimaging data introduces several domain-specific problems and considerations, leaving the overarching question of how to best structure and run experiments ambiguous. In this work, I cover two explicit pieces of this larger question, the relationship between data representation and predictive performance and a case study on issues related to data collected from disparate sites and cohorts. I then present the Brain Predictability toolbox, a soft- ware package to explicitly codify and make more broadly accessible to researchers the recommended steps in performing a predictive experiment, everything from framing a question to reporting results. This unique perspective ultimately offers recommen- dations, explicit analytical strategies, and example applications for using machine learning to study the brain
Application of Track Geometry Deterioration Modelling and Data Mining in Railway Asset Management
Modernin rautatiejärjestelmän hallinnassa rahankäyttö kohdistuu valtaosin nykyisen rataverkon korjauksiin ja parannuksiin ennemmin kuin uusien ratojen rakentamiseen. Nykyisen rataverkon kunnossapitotyöt aiheuttavat suurten kustannusten lisäksi myös usein liikennerajoitteita tai yhteyksien väliaikaisia sulkemisia, jotka heikentävät rataverkon käytettävyyttä Siispä oikea-aikainen ja pitkäaikaisia parannuksia aikaansaava kunnossapito ovat edellytyksiä kilpailukykyisille ja täsmällisille rautatiekuljetuksille. Tällainen kunnossapito vaatii vankan tietopohjan radan nykyisestä kunnosta päätöksenteon tueksi.
Ratainfran omistajat teettävät päätöksenteon tueksi useita erilaisia radan kuntoa kuvaavia mittauksia ja ylläpitävät kattavia omaisuustietorekistereitä. Kenties tärkein näistä datalähteistä on koneellisen radantarkastuksen tuottamat mittaustulokset, jotka kuvastavat radan geometrian kuntoa. Nämä mittaustulokset ovat tärkeitä, koska ne tuottavat luotettavaa kuntotietoa: mittaukset tehdään toistuvasti, 2–6 kertaa vuodessa Suomessa rataosasta riippuen, mittausvaunu pysyy useita vuosia samana, tulokset ovat hyvin toistettavia ja ne antavat hyvän yleiskuvan radan kunnosta. Vaikka laadukasta dataa on paljon saatavilla, käytännön omaisuudenhallinnassa on merkittäviä haasteita datan analysoinnissa, sillä vakiintuneita menetelmiä siihen on vähän. Käytännössä seurataan usein vain mittaustulosten raja-arvojen ylittymistä ja pyritään subjektiivisesti arvioimaan rakenteiden kunnon kehittymistä ja korjaustarpeita. Kehittyneen analytiikan puutteet estävät kuntotietojen laajamittaisen hyödyntämisen kunnossapidon suunnittelussa, mikä vaikeuttaa päätöksentekoa.
Tämän väitöskirjatutkimuksen päätavoitteita olivat kehittää ratageometrian heikkenemiseen mallintamismenetelmiä, soveltaa tiedonlouhintaa saatavilla olevan omaisuusdatan analysointiin sekä jalkauttaa kyseiset tutkimustulokset käytännön rataomaisuudenhallintaan. Ratageometrian heikkenemisen mallintamismenetelmien kehittämisessä keskityttiin tuottamaan nykyisin saatavilla olevasta datasta uutta tietoa radan kunnon kehityksestä, tehdyn kunnossapidon tehokkuudesta sekä tulevaisuuden kunnossapitotarpeista. Tiedonlouhintaa sovellettiin ratageometrian heikkenemisen juurisyiden selvittämiseen rataomaisuusdatan perusteella. Lopuksi hyödynnettiin kypsyysmalleja perustana ratageometrian heikkenemisen mallinnuksen ja rataomaisuusdatan analytiikan käytäntöön viennille.
Tutkimustulosten perusteella suomalainen radantarkastus- ja rataomaisuusdata olivat riittäviä tavoiteltuihin analyyseihin. Tulokset osoittivat, että robusti lineaarinen optimointi soveltuu hyvin suomalaisen rataverkon ratageometrian heikkenemisen mallinnukseen. Mallinnuksen avulla voidaan tuottaa tunnuslukuja, jotka kuvaavat rakenteen kuntoa, kunnossapidon tehokkuutta ja tulevaa kunnossapitotarvetta, sekä muodostaa havainnollistavia visualisointeja datasta. Rataomaisuusdatan eksploratiiviseen tiedonlouhintaan käytetyn GUHA-menetelmän avulla voitiin selvittää mielenkiintoisia ja vaikeasti havaittavia korrelaatioita datasta. Näiden tulosten avulla saatiin uusia havaintoja ongelmallisista ratarakennetyypeistä. Havaintojen avulla voitiin kohdentaa jatkotutkimuksia näihin rakenteisiin, mikä ei olisi ollut mahdollista, jollei tiedonlouhinnan avulla olisi ensin tunnistettu näitä rakennetyyppejä. Kypsyysmallin soveltamisen avulla luotiin puitteet ratageometrian heikkenemisen mallintamisen ja rataomaisuusdatan analytiikan kehitykselle Suomen rataomaisuuden hallinnassa. Kypsyysmalli tarjosi käytännöllisen tavan lähestyä tarvittavaa kehitystyötä, kun eteneminen voitiin jaotella neljään eri kypsyystasoon, jotka loivat selkeitä välitavoitteita. Kypsyysmallin ja asetettujen välitavoitteiden avulla kehitys on suunniteltua ja edistystä voidaan jaotella, mikä antaa edellytykset tämän laajamittaisen kehityksen onnistuneelle läpiviennille.
Tämän väitöskirjatutkimuksen tulokset osoittavat, miten nykyisin saatavilla olevasta datasta saadaan täysin uutta ja merkityksellistä tietoa, kun sitä käsitellään kehittyneen analytiikan avulla. Tämä väitöskirja tarjoaa datankäsittelyratkaisujen luomisen ja soveltamisen lisäksi myös keinoja niiden käytäntöönpanolle, sillä tietopohjaisen päätöksenteon todelliset hyödyt saavutetaan vasta käytännön radanpidossa.In the management of a modern European railway system, spending is predominantly allocated to maintaining and renewing the existing rail network rather than constructing completely new lines. In addition to major costs, the maintenance and renewals of the existing rail network often cause traffic restrictions or line closures, which decrease the usability of the rail network. Therefore, timely maintenance that achieves long-lasting improvements is imperative for achieving competitive and punctual rail traffic. This kind of maintenance requires a strong knowledge base for decision making regarding the current condition of track structures.
Track owners commission several different measurements that depict the condition of track structures and have comprehensive asset management data repositories. Perhaps one of the most important data sources is the track recording car measurement history, which depicts the condition of track geometry at different times. These measurement results are important because they offer a reliable condition database; the measurements are done recurrently, two to six times a year in Finland depending on the track section; the same recording car is used for many years; the results are repeatable; and they provide a good overall idea of the condition of track structures. However, although high-quality data is available, there are major challenges in analysing the data in practical asset management because there are few established methods for analytics. Practical asset management typically only monitors whether given threshold values are exceeded and subjectively assesses maintenance needs and development in the condition of track structures. The lack of advanced analytics prevents the full utilisation of the available data in maintenance planning which hinders decision making.
The main goals of this dissertation study were to develop track geometry deterioration modelling methods, apply data mining in analysing currently available railway asset data, and implement the results from these studies into practical railway asset management. The development of track geometry deterioration modelling methods focused on utilising currently available data for producing novel information on the development in the condition of track structures, past maintenance effectiveness, and future maintenance needs. Data mining was applied in investigating the root causes of track geometry deterioration based on asset data. Finally, maturity models were applied as the basis for implementing track geometry deterioration modelling and track asset data analytics into practice.
Based on the research findings, currently available Finnish measurement and asset data was sufficient for the desired analyses. For the Finnish track inspection data, robust linear optimisation was developed for track geometry deterioration modelling. The modelling provided key figures, which depict the condition of structures, maintenance effectiveness, and future maintenance needs. Moreover, visualisations were created from the modelling to enable the practical use of the modelling results. The applied exploratory data mining method, General Unary Hypotheses Automaton (GUHA), could find interesting and hard-to-detect correlations within asset data. With these correlations, novel observations on problematic track structure types were made. The observations could be utilised for allocating further research for problematic track structures, which would not have been possible without using data mining to identify these structures. The implementation of track geometry deterioration and asset data analytics into practice was approached by applying maturity models. The use of maturity models offered a practical way of approaching future development, as the development could be divided into four maturity levels, which created clear incremental goals for development. The maturity model and the incremental goals enabled wide-scale development planning, in which the progress can be segmented and monitored, which enhances successful project completion.
The results from these studies demonstrate how currently available data can be used to provide completely new and meaningful information, when advanced analytics are used. In addition to novel solutions for data analytics, this dissertation research also provided methods for implementing the solutions, as the true benefits of knowledge-based decision making are obtained in only practical railway asset management
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