3,906 research outputs found
Quantifying dynamical spillover in co-evolving multiplex networks
Multiplex networks (a system of multiple networks that have different types
of links but share a common set of nodes) arise naturally in a wide spectrum of
fields. Theoretical studies show that in such multiplex networks, correlated
edge dynamics between the layers can have a profound effect on dynamical
processes. However, how to extract the correlations from real-world systems is
an outstanding challenge. Here we provide a null model based on Markov chains
to quantify correlations in edge dynamics found in longitudinal data of
multiplex networks. We use this approach on two different data sets: the
network of trade and alliances between nation states, and the email and
co-commit networks between developers of open source software. We establish the
existence of "dynamical spillover" showing the correlated formation (or
deletion) of edges of different types as the system evolves. The details of the
dynamics over time provide insight into potential causal pathways
A framework for the construction of generative models for mesoscale structure in multilayer networks
Multilayer networks allow one to represent diverse and coupled connectivity patterns—such as time-dependence, multiple subsystems, or both—that arise in many applications and which are difficult or awkward to incorporate into standard network representations. In the study of multilayer networks, it is important to investigate mesoscale (i.e., intermediate-scale) structures, such as dense sets of nodes known as communities, to discover network features that are not apparent at the microscale or the macroscale. The ill-defined nature of mesoscale structure and its ubiquity in empirical networks make it crucial to develop generative models that can produce the features that one encounters in empirical networks. Key purposes of such models include generating synthetic networks with empirical properties of interest, benchmarking mesoscale-detection methods and algorithms, and inferring structure in empirical multilayer networks. In this paper, we introduce a framework for the construction of generative models for mesoscale structures in multilayer networks. Our framework provides a standardized set of generative models, together with an associated set of principles from which they are derived, for studies of mesoscale structures in multilayer networks. It unifies and generalizes many existing models for mesoscale structures in fully ordered (e.g., temporal) and unordered (e.g., multiplex) multilayer networks. One can also use it to construct generative models for mesoscale structures in partially ordered multilayer networks (e.g., networks that are both temporal and multiplex). Our framework has the ability to produce many features of empirical multilayer networks, and it explicitly incorporates a user-specified dependency structure between layers. We discuss the parameters and properties of our framework, and we illustrate examples of its use with benchmark models for community-detection methods and algorithms in multilayer networks
MCMC-ODPR : primer design optimization using Markov Chain Monte Carlo sampling
Background
Next generation sequencing technologies often require numerous primer designs that require good target coverage that can be financially costly. We aimed to develop a system that would implement primer reuse to design degenerate primers that could be designed around SNPs, thus find the fewest necessary primers and the lowest cost whilst maintaining an acceptable coverage and provide a cost effective solution. We have implemented Metropolis-Hastings Markov Chain Monte Carlo for optimizing primer reuse. We call it the Markov Chain Monte Carlo Optimized Degenerate Primer Reuse (MCMC-ODPR) algorithm.
Results
After repeating the program 1020 times to assess the variance, an average of 17.14% fewer primers were found to be necessary using MCMC-ODPR for an equivalent coverage without implementing primer reuse. The algorithm was able to reuse primers up to five times. We compared MCMC-ODPR with single sequence primer design programs Primer3 and Primer-BLAST and achieved a lower primer cost per amplicon base covered of 0.21 and 0.19 and 0.18 primer nucleotides on three separate gene sequences, respectively. With multiple sequences, MCMC-ODPR achieved a lower cost per base covered of 0.19 than programs BatchPrimer3 and PAMPS, which achieved 0.25 and 0.64 primer nucleotides, respectively.
Conclusions
MCMC-ODPR is a useful tool for designing primers at various melting temperatures at good target coverage. By combining degeneracy with optimal primer reuse the user may increase coverage of sequences amplified by the designed primers at significantly lower costs. Our analyses showed that overall MCMC-ODPR outperformed the other primer-design programs in our study in terms of cost per covered base
Missing data in multiplex networks: a preliminary study
A basic problem in the analysis of social networks is missing data. When a
network model does not accurately capture all the actors or relationships in
the social system under study, measures computed on the network and ultimately
the final outcomes of the analysis can be severely distorted. For this reason,
researchers in social network analysis have characterised the impact of
different types of missing data on existing network measures. Recently a lot of
attention has been devoted to the study of multiple-network systems, e.g.,
multiplex networks. In these systems missing data has an even more significant
impact on the outcomes of the analyses. However, to the best of our knowledge,
no study has focused on this problem yet. This work is a first step in the
direction of understanding the impact of missing data in multiple networks. We
first discuss the main reasons for missingness in these systems, then we
explore the relation between various types of missing information and their
effect on network properties. We provide initial experimental evidence based on
both real and synthetic data.Comment: 7 page
Entrograms and coarse graining of dynamics on complex networks
Using an information theoretic point of view, we investigate how a dynamics
acting on a network can be coarse grained through the use of graph partitions.
Specifically, we are interested in how aggregating the state space of a Markov
process according to a partition impacts on the thus obtained lower-dimensional
dynamics. We highlight that for a dynamics on a particular graph there may be
multiple coarse grained descriptions that capture different, incomparable
features of the original process. For instance, a coarse graining induced by
one partition may be commensurate with a time-scale separation in the dynamics,
while another coarse graining may correspond to a different lower-dimensional
dynamics that preserves the Markov property of the original process. Taking
inspiration from the literature of Computational Mechanics, we find that a
convenient tool to summarise and visualise such dynamical properties of a
coarse grained model (partition) is the entrogram. The entrogram gathers
certain information-theoretic measures, which quantify how information flows
across time steps. These information theoretic quantities include the entropy
rate, as well as a measure for the memory contained in the process, i.e., how
well the dynamics can be approximated by a first order Markov process. We use
the entrogram to investigate how specific macro-scale connection patterns in
the state-space transition graph of the original dynamics result in desirable
properties of coarse grained descriptions. We thereby provide a fresh
perspective on the interplay between structure and dynamics in networks, and
the process of partitioning from an information theoretic perspective. We focus
on networks that may be approximated by both a core-periphery or a clustered
organization, and highlight that each of these coarse grained descriptions can
capture different aspects of a Markov process acting on the network.Comment: 17 pages, 6 figue
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