Tracking Control for Non-Minimum Phase System and Brain Computer Interface

For generations, humans dreamed about the ability to communicate and interact with machines through thought alone or to create devices that can peer into a person’s mind and thoughts. Researchers have developed new technologies to create brain computer interfaces (BCIs), communication systems that do not depend on the brain’s normal output pathways of peripheral nerves and muscles. The objective of the first part of this thesis is to develop a new BCI based on electroencephalography (EEG) to move a computer cursor over a short training period in real time. The work motivations of this part are to increase: speed and accuracy, as in BCI settings, subject has a few seconds to make a selection with a relatively high accuracy. Recently, improvements have been developed to make EEG more accurate by increasing the spatial resolution. One such improvement is the application of the surface Laplacian to the EEG, the second spatial derivative. Tripolar concentric ring electrodes (TCREs) automatically perform the Laplacian on the surface potentials and provide better spatial selectivity and signal-to-noise ratio than conventional EEG that is recorded with conventional disc electrodes. Another important feature using TCRE is the capability to record the EEG and the TCRE EEG (tEEG) signals concurrently from the same location on the scalp for the same electrical activity coming from the brain. In this part we also demonstrate that tEEG signals can enable users to control a computer cursor rapidly in different directions with significantly higher accuracy during their first session of training for 1D and 2D cursor control. Output tracking control of non-minimum phase systems is a highly challenging problem encountered in many practical engineering applications. Classical inversion techniques provide exact output tracking but lead to internal instability, whereas modern inversion methods provide stable asymptotic tracking but produce large transient errors. Both methods provide an approximation of feedback control, which leads to non robust systems, very sensitive to noise, considerable tracking errors and a significant singularity problem. Aiming at the problem of system inversion to the true system, the objective of the second part of this thesis is to develop a new method based on true inversion for minimum phase system and approximate inversion for non-minimum phase systems. The proposed algorithm is automatic and has minimal computational complexities which make it suitable for real-time control. The process to develop the proposed algorithm is partitioned into (1) minimum phase feedforward inverse filter, and (2) non-minimum phase inversion. In a minimum phase inversion, we consider the design of a feedforward controller to invert the response of a feedback loop that has stable zero locations. The complete control system consists of a feedforward controller cascaded with a closed-loop system. The outputs of the resulting inverse filter are delayed versions of the corresponding reference input signals, and delays are given by the vector relative degree of the closed-loop

Biomedical signal filtering for noisy environments

 Luke\u27s work addresses issue of robustly attenuating multi-source noise from surface EEG signals using a novel Adaptive-Multiple-Reference Least-Means-Squares filter (AMR-LMS). In practice, the filter successfully removes electrical interference and muscle noise generated during movement which contaminates EEG, allowing subjects to maintain maximum mobility throughout signal acquisition and during the use of a Brain Computer Interface

Multiple sensor integration for seizure onset detection in human patients comparing conventional disc versus novel tripolar concentric ring electrodes

As epilepsy affects approximately one percent of the world population, electrical stimulation of the brain has recently shown potential for additive seizure control therapy. Closed-loop systems that apply electrical stimulation when seizure onset is automatically detected require high accuracy of automatic seizure detection based on electrographic brain activity. To improve this accuracy we propose to use noninvasive tripolar concentric ring electrodes that have been shown to have significantly better signal-to-noise ratio, spatial selectivity, and mutual information compared to conventional disc electrodes. The proposed detection methodology is based on integration of multiple sensors using exponentially embedded family (EEF). In this preliminary study it is validated on over 26.3 hours of data collected using both tripolar concentric ring and conventional disc electrodes concurrently each from 7 human patients with epilepsy including five seizures. For a cross-validation based group model EEF correctly detected 100% and 80% of seizures respectively with \u3c0.76 and \u3c1.56 false positive detections per hour respectively for the two electrode modalities. These results clearly suggest the potential of seizure onset detection based on data from tripolar concentric ring electrodes. © 2013 IEEE

Psr1p interacts with SUN/sad1p and EB1/mal3p to establish the bipolar spindle

Regular Abstracts - Sunday Poster Presentations: no. 382During mitosis, interpolar microtubules from two spindle pole bodies (SPBs) interdigitate to create an antiparallel microtubule array for accommodating numerous regulatory proteins. Among these proteins, the kinesin-5 cut7p/Eg5 is the key player responsible for sliding apart antiparallel microtubules and thus helps in establishing the bipolar spindle. At the onset of mitosis, two SPBs are adjacent to one another with most microtubules running nearly parallel toward the nuclear envelope, creating an unfavorable microtubule configuration for the kinesin-5 kinesins. Therefore, how the cell organizes the antiparallel microtubule array in the first place at mitotic onset remains enigmatic. Here, we show that a novel protein psrp1p localizes to the SPB and plays a key role in organizing the antiparallel microtubule array. The absence of psr1+ leads to a transient monopolar spindle and massive chromosome loss. Further functional characterization demonstrates that psr1p is recruited to the SPB through interaction with the conserved SUN protein sad1p and that psr1p physically interacts with the conserved microtubule plus tip protein mal3p/EB1. These results suggest a model that psr1p serves as a linking protein between sad1p/SUN and mal3p/EB1 to allow microtubule plus ends to be coupled to the SPBs for organization of an antiparallel microtubule array. Thus, we conclude that psr1p is involved in organizing the antiparallel microtubule array in the first place at mitosis onset by interaction with SUN/sad1p and EB1/mal3p, thereby establishing the bipolar spindle.postprin

Removal of antagonistic spindle forces can rescue metaphase spindle length and reduce chromosome segregation defects

Regular Abstracts - Tuesday Poster Presentations: no. 1925Metaphase describes a phase of mitosis where chromosomes are attached and oriented on the bipolar spindle for subsequent segregation at anaphase. In diverse cell types, the metaphase spindle is maintained at a relatively constant length. Metaphase spindle length is proposed to be regulated by a balance of pushing and pulling forces generated by distinct sets of spindle microtubules and their interactions with motors and microtubule-associated proteins (MAPs). Spindle length appears important for chromosome segregation fidelity, as cells with shorter or longer than normal metaphase spindles, generated through deletion or inhibition of individual mitotic motors or MAPs, showed chromosome segregation defects. To test the force balance model of spindle length control and its effect on chromosome segregation, we applied fast microfluidic temperature-control with live-cell imaging to monitor the effect of switching off different combinations of antagonistic forces in the fission yeast metaphase spindle. We show that spindle midzone proteins kinesin-5 cut7p and microtubule bundler ase1p contribute to outward pushing forces, and spindle kinetochore proteins kinesin-8 klp5/6p and dam1p contribute to inward pulling forces. Removing these proteins individually led to aberrant metaphase spindle length and chromosome segregation defects. Removing these proteins in antagonistic combination rescued the defective spindle length and, in some combinations, also partially rescued chromosome segregation defects. Our results stress the importance of proper chromosome-to-microtubule attachment over spindle length regulation for proper chromosome segregation.postprin

Libro de actas. XXXV Congreso Anual de la Sociedad Española de Ingeniería Biomédica

596 p.CASEIB2017 vuelve a ser el foro de referencia a nivel nacional para el intercambio científico de conocimiento, experiencias y promoción de la I D i en Ingeniería Biomédica. Un punto de encuentro de científicos, profesionales de la industria, ingenieros biomédicos y profesionales clínicos interesados en las últimas novedades en investigación, educación y aplicación industrial y clínica de la ingeniería biomédica. En la presente edición, más de 160 trabajos de alto nivel científico serán presentados en áreas relevantes de la ingeniería biomédica, tales como: procesado de señal e imagen, instrumentación biomédica, telemedicina, modelado de sistemas biomédicos, sistemas inteligentes y sensores, robótica, planificación y simulación quirúrgica, biofotónica y biomateriales. Cabe destacar las sesiones dedicadas a la competición por el Premio José María Ferrero Corral, y la sesión de competición de alumnos de Grado en Ingeniería biomédica, que persiguen fomentar la participación de jóvenes estudiantes e investigadores