Saving Bones: a direct comparison of FTIR-ATR, whole bone percent nitrogen, and NIR

89th Annual Meeting of the American-Association-of-Physical-Anthropologists (AAPA), Los Angeles, CA, APR 15-18, 202

Multimodal MRI template creation in the ring-tailed lemur and rhesus macaque

We present a multimodal registration algorithm for simultaneous alignment of datasets with both scalar and tensor MRI images. We employ a volumetric, cubic B-spline parametrised transformation model. Regularisation is based on the logarithm of the singular values of the local Jacobian and ensures diffeomorphic warps. Tensor registration takes reorientation into account during optimisation, through a finite-strain approximation of rotation due to the warp. The combination of scalar, tensor and regularisation cost functions allows us to optimise the deformations in terms of tissue matching, orientation matching and distortion minimisation simultaneously. We apply our method to creating multimodal T2 and DTI MRI brain templates of two small primates (the ring-tailed lemur and rhesus macaque) from high-quality, ex vivo, 0.5/0.6 mm isotropic data. The resulting templates are of very high quality across both modalities and species. Tissue contrast in the T2 channel is high indicating excellent tissue-boundary alignment. The DTI channel displays strong anisotropy in white matter, as well as consistent left/right orientation information even in relatively isotropic grey matter regions. Finally, we demonstrate where the multimodal templating approach overcomes anatomical inconsistencies introduced by unimodal only methods

Multimodal MRI template creation in the ring-tailed lemur and rhesus macaque

We present a multimodal registration algorithm for simultaneous alignment of datasets with both scalar and tensor MRI images. We employ a volumetric, cubic B-spline parametrised transformation model. Regularisation is based on the logarithm of the singular values of the local Jacobian and ensures diffeomorphic warps. Tensor registration takes reorientation into account during optimisation, through a finite-strain approximation of rotation due to the warp. The combination of scalar, tensor and regularisation cost functions allows us to optimise the deformations in terms of tissue matching, orientation matching and distortion minimisation simultaneously. We apply our method to creating multimodal T2 and DTI MRI brain templates of two small primates (the ring-tailed lemur and rhesus macaque) from high-quality, ex vivo, 0.5/0.6 mm isotropic data. The resulting templates are of very high quality across both modalities and species. Tissue contrast in the T2 channel is high indicating excellent tissue-boundary alignment. The DTI channel displays strong anisotropy in white matter, as well as consistent left/right orientation information even in relatively isotropic grey matter regions. Finally, we demonstrate where the multimodal templating approach overcomes anatomical inconsistencies introduced by unimodal only methods

Multimodal MRI template creation in the ring-tailed lemur and rhesus macaque: Conference paper

We present a multimodal registration algorithm for simultaneous alignment of datasets with both scalar and tensor MRI images. We employ a volumetric, cubic B-spline parametrised transformation model. Regularisation is based on the logarithm of the singular values of the local Jacobian and ensures diffeomorphic warps. Tensor registration takes reorientation into account during optimisation, through a finite-strain approximation of rotation due to the warp. The combination of scalar, tensor and regularisation cost functions allows us to optimise the deformations in terms of tissue matching, orientation matching and distortion minimisation simultaneously. We apply our method to creating multimodal T2 and DTI MRI brain templates of two small primates (the ring-tailed lemur and rhesus macaque) from high-quality, ex vivo, 0.5/0.6 mm isotropic data. The resulting templates are of very high quality across both modalities and species. Tissue contrast in the T2 channel is high indicating excellent tissue-boundary alignment. The DTI channel displays strong anisotropy in white matter, as well as consistent left/right orientation information even in relatively isotropic grey matter regions. Finally, we demonstrate where the multimodal templating approach overcomes anatomical inconsistencies introduced by unimodal only methods

Animal Experimentation: Working Towards a Paradigm Change

Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.https://www.wellbeingintlstudiesrepository.org/ebooks/1018/thumbnail.jp