Skin Phantom for Biowearable Device Testing

The biowearable industry currently utilizes animals, humans, and cadavers for testing skin mounted bio-devices. There is a need for a sustainable skin phantom that is capable of simulating the properties of skin. We proposed a skin phantom educational kit that emulates the perspiration and electrical properties (i.e. impedance spectrum) of skin. This kit can mimic the effects of different sweat concentrations and geometrical structures and allows students to visualize how these properties change electrical measurements. We designed a three-layered model composed of silicone rubber sandwiched between agar, which is similar to the skin\u27s elastomeric and porous texture. We used simple and safe equipment such as a digital multimeter and a low-voltage power source for testing our educational model. We also constructed a computational model using COMSOL Multiphysics to simulate important skin phantom properties. Our COMSOL model is more complex than the agar-silicone layered model in the sense that it allows analysis of the impedance spectrum as a function of the perspiration mechanics. Through our COMSOL model, we achieved simulation of perspiration and studies on the effects of electrode distance, and material conductivity and relative permittivity in relation to impedance. From these tests, the simulation proves viable for scaling up to a realistic size, as our final model is sized-down for improved model development and testing purposes. Our COMSOL model serves as the groundwork for future improvements on replicating the skin’s mechanical, fluid, and electrical properties in a computer simulation

LC Sensor for biological tissue characterization

Over the past few decades, there has been growing interest and increased research on bio-implantable devices using RF telemetry links, enabling the continuous monitoring and recording of physiological data. However the dispersive properties of tissues make this a formidable task. In the present work, a novel technique for tissue characterization using an LC sensor is developed which allows for the extraction of the relative permittivity, and the conductivity of dispersive tissues. The resonant frequency of the sensor is monitored by measuring the input impedance of an external antenna, and correlated to the desired quantities. The impact of multi-layered dispersive tissues on the setup of the telemetry link is demonstrated where the role of the capacitor is analyzed. The sensor consists of a planar inductor, and an interdigital capacitor. Using an equivalent circuit model of the sensor that accounts for the properties of the encapsulating tissue, analytical expressions have been developed for the extraction of the tissue permittivity and conductivity. In addition, the effect of the thicknesses of the tissue layers on the sensor resonant frequency is studied. It is seen that the resonant frequency is strongly affected by the properties of the first layer, whereas additional layers prove to have little to no effect. A saturation thickness is defined that allows for the sensor to be implanted at a depth where it is only affected by the properties of the layer in which it is embedded. In order to analyze the telemetry system, a single loop antenna is evaluated in proximity to the biological tissue layer and the interaction of the electromagnetic field with the body is assessed in terms of specific absorption rate (SAR). It is studied through different multi-layered models composed of skin, fat and muscle, with typical values of tissue thickness. The introduction of multiple tissue layers as well as the misalignment effect is investigated from the SAR distribution. Finally, experimental validation has been performed with a telemetry link that consists of a loop antenna and a fabricated LC sensor immersed in single and multiple dispersive regions

Flexible Carbon-Based Electronics and Sensorized Neuroprosthesis

In the United States alone, there are more than 2 million people living with limb loss and prosthetic devices have long been the solution to recover their activities of daily living. However, many of the prosthetic users reported their dissatisfaction with current prostheses and some even abandoned theirs due to poor comfort and limited performance. To improve prosthetic control, advancements in surgical interfaces and sensorized neuroprosthesis are two major focus and have seen great potential. Both perspectives are presented in this work. Several reinnervated muscle surgeries have been invented to enable a better communication with muscle and nerves and a stable interface is essential to record robust muscle signals which are utilized to control a neuroprosthesis. Each muscle target may have slightly different anatomy and the current state-of-the-art implantable electrodes are complex and not easily reproducible and customizable. To address this problem, I present a simple, rapid electrode fabrication method to record muscle signals and easy-to-use electrode materials using carbon black/polydimethylsiloxane (PDMS) composite. Acute in vivo testing shows that the electrodes are highly functional and have the potential to enable large-scale muscle signal recordings with extensive data to improve the neuroprosthetic control. In addition to novel neural interfaces, sensory perception is also critical to improve the manipulation of objects with a prosthesis and enhances prosthetic performance and embodiment with feedback to the user. With recent advances in tactile sensing technology and neuromorphic stimulation interface, efficient real-time communication and functioning between them are still missing. In this work, I build and test a closed-loop system that integrates tactile sensing and neuromorphic electrical stimulation. The system functions in real time and the parameters of the sensory stimulation through transcutaneous electrical nerve stimulation (TENS) convey temporal information and dynamically change responding to real-time tactile data

Novel Bidirectional Body - Machine Interface to Control Upper Limb Prosthesis

Objective. The journey of a bionic prosthetic user is characterized by the opportunities and limitations involved in adopting a device (the prosthesis) that should enable activities of daily living (ADL). Within this context, experiencing a bionic hand as a functional (and, possibly, embodied) limb constitutes the premise for mitigating the risk of its abandonment through the continuous use of the device. To achieve such a result, different aspects must be considered for making the artificial limb an effective support for carrying out ADLs. Among them, intuitive and robust control is fundamental to improving amputees’ quality of life using upper limb prostheses. Still, as artificial proprioception is essential to perceive the prosthesis movement without constant visual attention, a good control framework may not be enough to restore practical functionality to the limb. To overcome this, bidirectional communication between the user and the prosthesis has been recently introduced and is a requirement of utmost importance in developing prosthetic hands. Indeed, closing the control loop between the user and a prosthesis by providing artificial sensory feedback is a fundamental step towards the complete restoration of the lost sensory-motor functions. Within my PhD work, I proposed the development of a more controllable and sensitive human-like hand prosthesis, i.e., the Hannes prosthetic hand, to improve its usability and effectiveness. Approach. To achieve the objectives of this thesis work, I developed a modular and scalable software and firmware architecture to control the Hannes prosthetic multi-Degree of Freedom (DoF) system and to fit all users’ needs (hand aperture, wrist rotation, and wrist flexion in different combinations). On top of this, I developed several Pattern Recognition (PR) algorithms to translate electromyographic (EMG) activity into complex movements. However, stability and repeatability were still unmet requirements in multi-DoF upper limb systems; hence, I started by investigating different strategies to produce a more robust control. To do this, EMG signals were collected from trans-radial amputees using an array of up to six sensors placed over the skin. Secondly, I developed a vibrotactile system to implement haptic feedback to restore proprioception and create a bidirectional connection between the user and the prosthesis. Similarly, I implemented an object stiffness detection to restore tactile sensation able to connect the user with the external word. This closed-loop control between EMG and vibration feedback is essential to implementing a Bidirectional Body - Machine Interface to impact amputees’ daily life strongly. For each of these three activities: (i) implementation of robust pattern recognition control algorithms, (ii) restoration of proprioception, and (iii) restoration of the feeling of the grasped object's stiffness, I performed a study where data from healthy subjects and amputees was collected, in order to demonstrate the efficacy and usability of my implementations. In each study, I evaluated both the algorithms and the subjects’ ability to use the prosthesis by means of the F1Score parameter (offline) and the Target Achievement Control test-TAC (online). With this test, I analyzed the error rate, path efficiency, and time efficiency in completing different tasks. Main results. Among the several tested methods for Pattern Recognition, the Non-Linear Logistic Regression (NLR) resulted to be the best algorithm in terms of F1Score (99%, robustness), whereas the minimum number of electrodes needed for its functioning was determined to be 4 in the conducted offline analyses. Further, I demonstrated that its low computational burden allowed its implementation and integration on a microcontroller running at a sampling frequency of 300Hz (efficiency). Finally, the online implementation allowed the subject to simultaneously control the Hannes prosthesis DoFs, in a bioinspired and human-like way. In addition, I performed further tests with the same NLR-based control by endowing it with closed-loop proprioceptive feedback. In this scenario, the results achieved during the TAC test obtained an error rate of 15% and a path efficiency of 60% in experiments where no sources of information were available (no visual and no audio feedback). Such results demonstrated an improvement in the controllability of the system with an impact on user experience. Significance. The obtained results confirmed the hypothesis of improving robustness and efficiency of a prosthetic control thanks to of the implemented closed-loop approach. The bidirectional communication between the user and the prosthesis is capable to restore the loss of sensory functionality, with promising implications on direct translation in the clinical practice

Battery-less near field communications (nfc) sensors for internet of things (iot) applications

L’ implementació de la tecnologia de comunicació de camp proper (NFC) en els telèfons intel·ligents no para de créixer degut a l’ús d’aquesta per fer pagaments, això, junt amb el fet de poder aprofitar l’energia generada pel mòbil no només per la comunicació, sinó també per transmetre energia, el baix cost dels xips NFC, i el fet de que els telèfons tinguin connectivitat amb internet, possibilita i fa molt interesant el disseny d’etiquetes sense bateria incorporant-hi sensors i poder enviar la informació al núvol, dins del creixent escenari de l’internet de les coses (IoT). La present Tesi estudia la viabilitat d’aquests sensors, analitzant la màxima distància entre lector i sensor per proveir la potència necessària, presenta tècniques per augmentar el rang d’operació, i analitza els efectes de certs materials quan aquests estan propers a les antenes. Diversos sensors han estat dissenyats i analitzats i son presentats en aquest treball. Aquests son: Una etiqueta que mesura la humitat de la terra, la temperatura i la humitat relativa de l’aire per controlar les condicions de plantes. Un sensor per detectar la humitat en bolquers, imprès en material flexible que s’adapta a la forma del bolquer. Dues aplicacions, una per estimació de pH i una altre per avaluar el grau de maduració de fruites, basats en un sensor de color. I, per últim, s’estudia la viabilitat de sensors en implants per aplicacions mèdiques, analitzant l’efecte del cos i proposant un sistema per augmentar la profunditat a la que aquests es poden llegir utilitzant un telèfon mòbil. Tots aquests sensors poden ser alimentats i llegits per qualsevol dispositiu que disposin de connexió NFC.La implementación de la tecnología de comunicaciones de campo cercano (NFC) en los teléfonos inteligentes no para de crecer debido al uso de esta para llevar a cabo pagos, esto, junto con el hecho de poder aprovechar la energía generada por el móvil no sólo para la comunicación, sino también para transmitir energía, el bajo coste de los chips NFC, i el hecho que los teléfonos tengan conectividad a internet, posibilita y hace muy interesante el diseño de etiquetas sin batería que incorporen sensores i poder enviar la información a la nube, enmarcado en el creciente escenario del internet de las cosas (IoT). La presente Tesis estudia la viabilidad de estos sensores, analizando la máxima distancia entre lector i sensor para proveer la potencia necesaria, presenta técnicas para aumentar el rango de operación, y analiza los efectos de ciertos materiales cuando estos están cerca de las antenas. Varios sensores han sido diseñados y analizados y son presentados en este trabajo. Estos son: Una etiqueta que mide la humedad de la tierra, la temperatura y la humedad relativa del aire para controlar las condiciones de plantas. Un sensor para detectar la humedad en pañales, impreso en material flexible que se adapta a la forma del pañal. Dos aplicaciones, una para estimación de pH y otra para evaluar el grado de maduración de frutas, basados en un sensor de color. Y, por último, se estudia la viabilidad de sensores en implantes para aplicaciones médicas, analizando el efecto del cuerpo y proponiendo un sistema para aumentar la profundidad a la que estos se pueden leer usando un teléfono móvil. Todos estos sensores pueden ser alimentados y leídos por cualquier dispositivo que disponga de conexión NFC.The implementation of near field communication (NFC) technology into smartphones grows rapidly due the use of this technology as a payment system. This, altogether with the fact that the energy generated by the phone can be used not only to communicate but for power transfer as well, the low-cost of the NFC chips, and the fact that the smartphones have connectivity to internet, makes possible and very interesting the design of battery-less sensing tags which information can be sent to the cloud, within the growing internet of things (IoT) scenario. This Thesis studies the feasibility of these sensors, analysing the maximum distance between reader and sensor to provide the necessary power, presents techniques to increase the range of operation, and analyses the effects of certain materials when they are near to the antennas. Several sensors have been designed and analysed and are presented in this work. These are: a tag that measures the soil moisture, the temperature and the relative humidity of the air to control the conditions of plants. A moisture sensor for diapers, printed on flexible material that adapts to the diaper shape. Two applications, one for pH estimation and another for assessing the degree of fruit ripening, based on a colour sensor. And finally, the feasibility of sensors in implants for medical applications is studied, analysing the effect of the body and proposing a system to increase the depth at which they can be read using a mobile phone. All of these sensors can be powered and read by any NFC enabled device

Analysis and Design of Footwear Antennas

Wearable technologies are found in an increasing number of applications including sport and medical monitoring, gaming and consumer electronics. Sensors are used to monitor vital signs and are located on various parts of the body. Footwear sensors permit the collection of data relating to gait, running style, physiotherapy and research. The data is sent from sensors to on-body hubs, often using wired technology, which can impact gait characteristics. This thesis describes the design of footwear antennas for wireless sensor telemetry. The work addresses the challenges of placing antennas close to the foot as well as the proximity to the ground. Guidelines for polarization are presented. The channel link between footwear and wrist is investigated for both narrowband and wideband channels across different frequencies. The effects of the body proximity and movement were gauged for walking subjects and are described in terms of the Rician Distribution K-factor. Different antenna solutions are presented including UWB antennas on various footwear locations as well as 433 MHz integrated antennas in the insole. Both directional and omnidirectional antennas were considered for UWB and the evaluation was for both time-domain and frequencydomain. The research established new ideas that challenge the old paradigm of the waist as the best hub position, demonstrating that a hub on the footwear using directional antennas outperforms a hub on the waist using an omnidirectional antenna. The cumulative distribution functions of measured path gains are evaluated and the results are described in terms of the achievable minimum data rate considering the Body Area Network standard