4,268 research outputs found
Mesh-to-raster based non-rigid registration of multi-modal images
Region of interest (ROI) alignment in medical images plays a crucial role in
diagnostics, procedure planning, treatment, and follow-up. Frequently, a model
is represented as triangulated mesh while the patient data is provided from CAT
scanners as pixel or voxel data. Previously, we presented a 2D method for
curve-to-pixel registration. This paper contributes (i) a general
mesh-to-raster (M2R) framework to register ROIs in multi-modal images; (ii) a
3D surface-to-voxel application, and (iii) a comprehensive quantitative
evaluation in 2D using ground truth provided by the simultaneous truth and
performance level estimation (STAPLE) method. The registration is formulated as
a minimization problem where the objective consists of a data term, which
involves the signed distance function of the ROI from the reference image, and
a higher order elastic regularizer for the deformation. The evaluation is based
on quantitative light-induced fluoroscopy (QLF) and digital photography (DP) of
decalcified teeth. STAPLE is computed on 150 image pairs from 32 subjects, each
showing one corresponding tooth in both modalities. The ROI in each image is
manually marked by three experts (900 curves in total). In the QLF-DP setting,
our approach significantly outperforms the mutual information-based
registration algorithm implemented with the Insight Segmentation and
Registration Toolkit (ITK) and Elastix
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A Hybrid Similarity Measure Framework for Multimodal Medical Image Registration
Medical imaging is widely used today to facilitate both disease diagnosis and treatment planning practice, with a key prerequisite being the systematic process of medical image registration (MIR) to align either mono or multimodal images of different anatomical parts of the human body. MIR utilises a similarity measure (SM) to quantify the level of spatial alignment and is particularly demanding due to the presence of inherent modality characteristics like intensity non-uniformities (INU) in magnetic resonance images and large homogeneous non-vascular regions in retinal images. While various intensity and feature-based SMs exist for MIR, mutual information (MI) has become established because of its computational efficiency and ability to register multimodal images. It is however, very sensitive to interpolation artefacts in the presence of INU with noise and can be compromised when overlapping areas are small. Recently MI-based hybrid variants which combine regional features with intensity have emerged, though these incur high dimensionality and large computational overheads.
To address these challenges and secure accurate, efficient and robust registration of images containing high INU, noise and large homogeneous regions, this thesis presents a new hybrid SM framework for 2D multimodal rigid MIR. The framework consistently provides superior quantitative and qualitative performance, while offering a uniquely flexible design trade-off between registration accuracy and computational time. It makes three significant technical contributions to the field: i) An expectation maximisation-based principal component analysis with mutual information (EMPCA-MI) framework incorporating neighbourhood feature information; ii) Two innovative enhancements to reduce information redundancy and improve MI computational efficiency; and iii) an adaptive algorithm to select the most significant principal components for feature selection.
The thesis findings conclusively confirm the hybrid SM framework offers an accurate and robust 2D registration solution for challenging multimodal medical imaging datasets, while its inherent flexibility means it can also be extended to the 3D registration domain
A generalisable framework for saliency-based line segment detection
Here we present a novel, information-theoretic salient line segment detector. Existing line detectors typically only use the image gradient to search for potential lines. Consequently, many lines are found, particularly in repetitive scenes. In contrast, our approach detects lines that define regions of significant divergence between pixel intensity or colour statistics. This results in a novel detector that naturally avoids the repetitive parts of a scene while detecting the strong, discriminative lines present. We furthermore use our approach as a saliency filter on existing line detectors to more efficiently detect salient line segments. The approach is highly generalisable, depending only on image statistics rather than image gradient; and this is demonstrated by an extension to depth imagery. Our work is evaluated against a number of other line detectors and a quantitative evaluation demonstrates a significant improvement over existing line detectors for a range of image transformation
A generalisable framework for saliency-based line segment detection
Here we present a novel, information-theoretic salient line segment detector. Existing line detectors typically only use the image gradient to search for potential lines. Consequently, many lines are found, particularly in repetitive scenes. In contrast, our approach detects lines that define regions of significant divergence between pixel intensity or colour statistics. This results in a novel detector that naturally avoids the repetitive parts of a scene while detecting the strong, discriminative lines present. We furthermore use our approach as a saliency filter on existing line detectors to more efficiently detect salient line segments. The approach is highly generalisable, depending only on image statistics rather than image gradient; and this is demonstrated by an extension to depth imagery. Our work is evaluated against a number of other line detectors and a quantitative evaluation demonstrates a significant improvement over existing line detectors for a range of image transformation
Information-Theoretic Registration with Explicit Reorientation of Diffusion-Weighted Images
We present an information-theoretic approach to the registration of images
with directional information, and especially for diffusion-Weighted Images
(DWI), with explicit optimization over the directional scale. We call it
Locally Orderless Registration with Directions (LORD). We focus on normalized
mutual information as a robust information-theoretic similarity measure for
DWI. The framework is an extension of the LOR-DWI density-based hierarchical
scale-space model that varies and optimizes the integration, spatial,
directional, and intensity scales. As affine transformations are insufficient
for inter-subject registration, we extend the model to non-rigid deformations.
We illustrate that the proposed model deforms orientation distribution
functions (ODFs) correctly and is capable of handling the classic complex
challenges in DWI-registrations, such as the registration of fiber-crossings
along with kissing, fanning, and interleaving fibers. Our experimental results
clearly illustrate a novel promising regularizing effect, that comes from the
nonlinear orientation-based cost function. We show the properties of the
different image scales and, we show that including orientational information in
our model makes the model better at retrieving deformations in contrast to
standard scalar-based registration.Comment: 16 pages, 19 figure
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