Privacy Preserving Domain Adaptation for Semantic Segmentation of Medical Images

Convolutional neural networks (CNNs) have led to significant improvements in tasks involving semantic segmentation of images. CNNs are vulnerable in the area of biomedical image segmentation because of distributional gap between two source and target domains with different data modalities which leads to domain shift. Domain shift makes data annotations in new modalities necessary because models must be retrained from scratch. Unsupervised domain adaptation (UDA) is proposed to adapt a model to new modalities using solely unlabeled target domain data. Common UDA algorithms require access to data points in the source domain which may not be feasible in medical imaging due to privacy concerns. In this work, we develop an algorithm for UDA in a privacy-constrained setting, where the source domain data is inaccessible. Our idea is based on encoding the information from the source samples into a prototypical distribution that is used as an intermediate distribution for aligning the target domain distribution with the source domain distribution. We demonstrate the effectiveness of our algorithm by comparing it to state-of-the-art medical image semantic segmentation approaches on two medical image semantic segmentation datasets

How much BiGAN and CycleGAN-learned hidden features are effective for COVID-19 detection from CT images? A comparative study

Bidirectional generative adversarial networks (BiGANs) and cycle generative adversarial networks (CycleGANs) are two emerging machine learning models that, up to now, have been used as generative models, i.e., to generate output data sampled from a target probability distribution. However, these models are also equipped with encoding modules, which, after weakly supervised training, could be, in principle, exploited for the extraction of hidden features from the input data. At the present time, how these extracted features could be effectively exploited for classification tasks is still an unexplored field. Hence, motivated by this consideration, in this paper, we develop and numerically test the performance of a novel inference engine that relies on the exploitation of BiGAN and CycleGAN-learned hidden features for the detection of COVID-19 disease from other lung diseases in computer tomography (CT) scans. In this respect, the main contributions of the paper are twofold. First, we develop a kernel density estimation (KDE)-based inference method, which, in the training phase, leverages the hidden features extracted by BiGANs and CycleGANs for estimating the (a priori unknown) probability density function (PDF) of the CT scans of COVID-19 patients and, then, in the inference phase, uses it as a target COVID-PDF for the detection of COVID diseases. As a second major contribution, we numerically evaluate and compare the classification accuracies of the implemented BiGAN and CycleGAN models against the ones of some state-of-the-art methods, which rely on the unsupervised training of convolutional autoencoders (CAEs) for attaining feature extraction. The performance comparisons are carried out by considering a spectrum of different training loss functions and distance metrics. The obtained classification accuracies of the proposed CycleGAN-based (resp., BiGAN-based) models outperform the corresponding ones of the considered benchmark CAE-based models of about 16% (resp., 14%)