Single- and multi-microphone speech dereverberation using spectral enhancement

In speech communication systems, such as voice-controlled systems, hands-free mobile telephones, and hearing aids, the received microphone signals are degraded by room reverberation, background noise, and other interferences. This signal degradation may lead to total unintelligibility of the speech and decreases the performance of automatic speech recognition systems. In the context of this work reverberation is the process of multi-path propagation of an acoustic sound from its source to one or more microphones. The received microphone signal generally consists of a direct sound, reflections that arrive shortly after the direct sound (commonly called early reverberation), and reflections that arrive after the early reverberation (commonly called late reverberation). Reverberant speech can be described as sounding distant with noticeable echo and colouration. These detrimental perceptual effects are primarily caused by late reverberation, and generally increase with increasing distance between the source and microphone. Conversely, early reverberations tend to improve the intelligibility of speech. In combination with the direct sound it is sometimes referred to as the early speech component. Reduction of the detrimental effects of reflections is evidently of considerable practical importance, and is the focus of this dissertation. More specifically the dissertation deals with dereverberation techniques, i.e., signal processing techniques to reduce the detrimental effects of reflections. In the dissertation, novel single- and multimicrophone speech dereverberation algorithms are developed that aim at the suppression of late reverberation, i.e., at estimation of the early speech component. This is done via so-called spectral enhancement techniques that require a specific measure of the late reverberant signal. This measure, called spectral variance, can be estimated directly from the received (possibly noisy) reverberant signal(s) using a statistical reverberation model and a limited amount of a priori knowledge about the acoustic channel(s) between the source and the microphone(s). In our work an existing single-channel statistical reverberation model serves as a starting point. The model is characterized by one parameter that depends on the acoustic characteristics of the environment. We show that the spectral variance estimator that is based on this model, can only be used when the source-microphone distance is larger than the so-called critical distance. This is, crudely speaking, the distance where the direct sound power is equal to the total reflective power. A generalization of the statistical reverberation model in which the direct sound is incorporated is developed. This model requires one additional parameter that is related to the ratio between the direct sound energy and the sound energy of all reflections. The generalized model is used to derive a novel spectral variance estimator. When the novel estimator is used for dereverberation rather than the existing estimator, and the source-microphone distance is smaller than the critical distance, the dereverberation performance is significantly increased. Single-microphone systems only exploit the temporal and spectral diversity of the received signal. Reverberation, of course, also induces spatial diversity. To additionally exploit this diversity, multiple microphones must be used, and their outputs must be combined by a suitable spatial processor such as the so-called delay and sum beamformer. It is not a priori evident whether spectral enhancement is best done before or after the spatial processor. For this reason we investigate both possibilities, as well as a merge of the spatial processor and the spectral enhancement technique. An advantage of the latter option is that the spectral variance estimator can be further improved. Our experiments show that the use of multiple microphones affords a significant improvement of the perceptual speech quality. The applicability of the theory developed in this dissertation is demonstrated using a hands-free communication system. Since hands-free systems are often used in a noisy and reverberant environment, the received microphone signal does not only contain the desired signal but also interferences such as room reverberation that is caused by the desired source, background noise, and a far-end echo signal that results from a sound that is produced by the loudspeaker. Usually an acoustic echo canceller is used to cancel the far-end echo. Additionally a post-processor is used to suppress background noise and residual echo, i.e., echo which could not be cancelled by the echo canceller. In this work a novel structure and post-processor for an acoustic echo canceller are developed. The post-processor suppresses late reverberation caused by the desired source, residual echo, and background noise. The late reverberation and late residual echo are estimated using the generalized statistical reverberation model. Experimental results convincingly demonstrate the benefits of the proposed system for suppressing late reverberation, residual echo and background noise. The proposed structure and post-processor have a low computational complexity, a highly modular structure, can be seamlessly integrated into existing hands-free communication systems, and affords a significant increase of the listening comfort and speech intelligibility

A MODEL FOR PREDICTING THE PERFORMANCE OF IP VIDEOCONFERENCING

With the incorporation of free desktop videoconferencing (DVC) software on the majority of the world's PCs, over the recent years, there has, inevitably, been considerable interest in using DVC over the Internet. The growing popularity of DVC increases the need for multimedia quality assessment. However, the task of predicting the perceived multimedia quality over the Internet Protocol (IP) networks is complicated by the fact that the audio and video streams are susceptible to unique impairments due to the unpredictable nature of IP networks, different types of task scenarios, different levels of complexity, and other related factors. To date, a standard consensus to define the IP media Quality of Service (QoS) has yet to be implemented. The thesis addresses this problem by investigating a new approach to assess the quality of audio, video, and audiovisual overall as perceived in low cost DVC systems. The main aim of the thesis is to investigate current methods used to assess the perceived IP media quality, and then propose a model which will predict the quality of audiovisual experience from prevailing network parameters. This thesis investigates the effects of various traffic conditions, such as, packet loss, jitter, and delay and other factors that may influence end user acceptance, when low cost DVC is used over the Internet. It also investigates the interaction effects between the audio and video media, and the issues involving the lip sychronisation error. The thesis provides the empirical evidence that the subjective mean opinion score (MOS) of the perceived multimedia quality is unaffected by lip synchronisation error in low cost DVC systems. The data-gathering approach that is advocated in this thesis involves both field and laboratory trials to enable the comparisons of results between classroom-based experiments and real-world environments to be made, and to provide actual real-world confirmation of the bench tests. The subjective test method was employed since it has been proven to be more robust and suitable for the research studies, as compared to objective testing techniques. The MOS results, and the number of observations obtained, have enabled a set of criteria to be established that can be used to determine the acceptable QoS for given network conditions and task scenarios. Based upon these comprehensive findings, the final contribution of the thesis is the proposal of a new adaptive architecture method that is intended to enable the performance of IP based DVC of a particular session to be predicted for a given network condition

Ultra-high-speed imaging of bubbles interacting with cells and tissue

Ultrasound contrast microbubbles are exploited in molecular imaging, where bubbles are directed to target cells and where their high-scattering cross section to ultrasound allows for the detection of pathologies at a molecular level. In therapeutic applications vibrating bubbles close to cells may alter the permeability of cell membranes, and these systems are therefore highly interesting for drug and gene delivery applications using ultrasound. In a more extreme regime bubbles are driven through shock waves to sonoporate or kill cells through intense stresses or jets following inertial bubble collapse. Here, we elucidate some of the underlying mechanisms using the 25-Mfps camera Brandaris128, resolving the bubble dynamics and its interactions with cells. We quantify acoustic microstreaming around oscillating bubbles close to rigid walls and evaluate the shear stresses on nonadherent cells. In a study on the fluid dynamical interaction of cavitation bubbles with adherent cells, we find that the nonspherical collapse of bubbles is responsible for cell detachment. We also visualized the dynamics of vibrating microbubbles in contact with endothelial cells followed by fluorescent imaging of the transport of propidium iodide, used as a membrane integrity probe, into these cells showing a direct correlation between cell deformation and cell membrane permeability