Multi-Instance Multi-Label Learning

In this paper, we propose the MIML (Multi-Instance Multi-Label learning) framework where an example is described by multiple instances and associated with multiple class labels. Compared to traditional learning frameworks, the MIML framework is more convenient and natural for representing complicated objects which have multiple semantic meanings. To learn from MIML examples, we propose the MimlBoost and MimlSvm algorithms based on a simple degeneration strategy, and experiments show that solving problems involving complicated objects with multiple semantic meanings in the MIML framework can lead to good performance. Considering that the degeneration process may lose information, we propose the D-MimlSvm algorithm which tackles MIML problems directly in a regularization framework. Moreover, we show that even when we do not have access to the real objects and thus cannot capture more information from real objects by using the MIML representation, MIML is still useful. We propose the InsDif and SubCod algorithms. InsDif works by transforming single-instances into the MIML representation for learning, while SubCod works by transforming single-label examples into the MIML representation for learning. Experiments show that in some tasks they are able to achieve better performance than learning the single-instances or single-label examples directly.Comment: 64 pages, 10 figures; Artificial Intelligence, 201

Large-Scale Multi-Label Learning with Incomplete Label Assignments

Multi-label learning deals with the classification problems where each instance can be assigned with multiple labels simultaneously. Conventional multi-label learning approaches mainly focus on exploiting label correlations. It is usually assumed, explicitly or implicitly, that the label sets for training instances are fully labeled without any missing labels. However, in many real-world multi-label datasets, the label assignments for training instances can be incomplete. Some ground-truth labels can be missed by the labeler from the label set. This problem is especially typical when the number instances is very large, and the labeling cost is very high, which makes it almost impossible to get a fully labeled training set. In this paper, we study the problem of large-scale multi-label learning with incomplete label assignments. We propose an approach, called MPU, based upon positive and unlabeled stochastic gradient descent and stacked models. Unlike prior works, our method can effectively and efficiently consider missing labels and label correlations simultaneously, and is very scalable, that has linear time complexities over the size of the data. Extensive experiments on two real-world multi-label datasets show that our MPU model consistently outperform other commonly-used baselines

Automatic Emphysema Detection using Weakly Labeled HRCT Lung Images

A method for automatically quantifying emphysema regions using High-Resolution Computed Tomography (HRCT) scans of patients with chronic obstructive pulmonary disease (COPD) that does not require manually annotated scans for training is presented. HRCT scans of controls and of COPD patients with diverse disease severity are acquired at two different centers. Textural features from co-occurrence matrices and Gaussian filter banks are used to characterize the lung parenchyma in the scans. Two robust versions of multiple instance learning (MIL) classifiers, miSVM and MILES, are investigated. The classifiers are trained with the weak labels extracted from the forced expiratory volume in one minute (FEV$_1$) and diffusing capacity of the lungs for carbon monoxide (DLCO). At test time, the classifiers output a patient label indicating overall COPD diagnosis and local labels indicating the presence of emphysema. The classifier performance is compared with manual annotations by two radiologists, a classical density based method, and pulmonary function tests (PFTs). The miSVM classifier performed better than MILES on both patient and emphysema classification. The classifier has a stronger correlation with PFT than the density based method, the percentage of emphysema in the intersection of annotations from both radiologists, and the percentage of emphysema annotated by one of the radiologists. The correlation between the classifier and the PFT is only outperformed by the second radiologist. The method is therefore promising for facilitating assessment of emphysema and reducing inter-observer variability.Comment: Accepted at PLoS ON

Fast, Exact and Multi-Scale Inference for Semantic Image Segmentation with Deep Gaussian CRFs

In this work we propose a structured prediction technique that combines the virtues of Gaussian Conditional Random Fields (G-CRF) with Deep Learning: (a) our structured prediction task has a unique global optimum that is obtained exactly from the solution of a linear system (b) the gradients of our model parameters are analytically computed using closed form expressions, in contrast to the memory-demanding contemporary deep structured prediction approaches that rely on back-propagation-through-time, (c) our pairwise terms do not have to be simple hand-crafted expressions, as in the line of works building on the DenseCRF, but can rather be `discovered' from data through deep architectures, and (d) out system can trained in an end-to-end manner. Building on standard tools from numerical analysis we develop very efficient algorithms for inference and learning, as well as a customized technique adapted to the semantic segmentation task. This efficiency allows us to explore more sophisticated architectures for structured prediction in deep learning: we introduce multi-resolution architectures to couple information across scales in a joint optimization framework, yielding systematic improvements. We demonstrate the utility of our approach on the challenging VOC PASCAL 2012 image segmentation benchmark, showing substantial improvements over strong baselines. We make all of our code and experiments available at {https://github.com/siddharthachandra/gcrf}Comment: Our code is available at https://github.com/siddharthachandra/gcr

Patch-based Convolutional Neural Network for Whole Slide Tissue Image Classification

Convolutional Neural Networks (CNN) are state-of-the-art models for many image classification tasks. However, to recognize cancer subtypes automatically, training a CNN on gigapixel resolution Whole Slide Tissue Images (WSI) is currently computationally impossible. The differentiation of cancer subtypes is based on cellular-level visual features observed on image patch scale. Therefore, we argue that in this situation, training a patch-level classifier on image patches will perform better than or similar to an image-level classifier. The challenge becomes how to intelligently combine patch-level classification results and model the fact that not all patches will be discriminative. We propose to train a decision fusion model to aggregate patch-level predictions given by patch-level CNNs, which to the best of our knowledge has not been shown before. Furthermore, we formulate a novel Expectation-Maximization (EM) based method that automatically locates discriminative patches robustly by utilizing the spatial relationships of patches. We apply our method to the classification of glioma and non-small-cell lung carcinoma cases into subtypes. The classification accuracy of our method is similar to the inter-observer agreement between pathologists. Although it is impossible to train CNNs on WSIs, we experimentally demonstrate using a comparable non-cancer dataset of smaller images that a patch-based CNN can outperform an image-based CNN

Hashing as Tie-Aware Learning to Rank

Hashing, or learning binary embeddings of data, is frequently used in nearest neighbor retrieval. In this paper, we develop learning to rank formulations for hashing, aimed at directly optimizing ranking-based evaluation metrics such as Average Precision (AP) and Normalized Discounted Cumulative Gain (NDCG). We first observe that the integer-valued Hamming distance often leads to tied rankings, and propose to use tie-aware versions of AP and NDCG to evaluate hashing for retrieval. Then, to optimize tie-aware ranking metrics, we derive their continuous relaxations, and perform gradient-based optimization with deep neural networks. Our results establish the new state-of-the-art for image retrieval by Hamming ranking in common benchmarks.Comment: 15 pages, 3 figures. IEEE Conference on Computer Vision and Pattern Recognition (CVPR), 201