Analog and Mixed Signal Design towards a Miniaturized Sleep Apnea Monitoring Device

Sleep apnea is a sleep-induced breathing disorder with symptoms of momentary and often repetitive cessations in breathing rhythm or sustained reductions in breathing amplitude. The phenomenon is known to occur with varying degrees of severity in literally millions of people around the world and cause a range of chronicle health issues. In spite of its high prevalence and serious consequences, nearly 80% of people with sleep apnea condition remain undiagnosed. The current standard diagnosis technique, termed polysomnography or PSG, requires the patient to schedule and undergo a complex full-night sleep study in a specially-equipped sleep lab. Due to both high cost and substantial inconvenience, millions of apnea patients are still undiagnosed and thus untreated. This research work aims at a simple, reliable, and miniaturized solution for in-home sleep apnea diagnosis purposes. The proposed solution bears high-level integration and minimal interference with sleeping patients, allowing them to monitor their apnea conditions at the comfort of their homes. Based on a MEMS sensor and an effective apnea detection algorithm, a low-cost single-channel apnea screening solution is proposed. A custom designed IC chip implements the apnea detection algorithm using time-domain signal processing techniques. The chip performs autonomous apnea detection and scoring based on the patient’s airflow signals detected by the MEMS sensor. Variable sensitivity is enabled to accommodate different breathing signal amplitudes. The IC chip was fabricated in standard 0.5-μm CMOS technology. A prototype device was designed and assembled including a MEMS sensor, the apnea detection IC chip, a PSoC platform, and wireless transceiver for data transmission. The prototype device demonstrates a valuable screening solution with great potential to reach the broader public with undiagnosed apnea conditions. In a battery-operated miniaturized medical device, an energy-efficient analog-to-digital converter is an integral part linking the analog world of biomedical signals and the digital domain with powerful signal processing capabilities. This dissertation includes the detailed design of a successive approximation register (SAR) ADC for ultra-low power applications. The ADC adopts an asynchronous 2b/step scheme that halves both conversion time and DAC/digital circuit’s switching activities to reduce static and dynamic energy consumption. A low-power sleep mode is engaged at the end of all conversion steps during each clock period. The technical contributions of this ADC design include an innovative 2b/step reference scheme based on a hybrid R-2R/C-3C DAC, an interpolation-assisted time-domain 2b comparison scheme, and a TDC with dual-edge-comparison mechanism. The prototype ADC was fabricated in 0.18μm CMOS process with an active area of 0.103 mm^(2), and achieves an ENoB of 9.2 bits and an FoM of 6.7 fJ/conversion-step at 100-kS/s

Modular integration and on-chip sensing approaches for tunable fluid control polymer microdevices

228 p.Doktore tesi honetan mikroemariak kontrolatzeko elementuak diseinatu eta garatuko dira, mikrobalbula eta mikrosentsore bat zehazki. Ondoren, gailu horiek batera integratuko dira likido emari kontrolatzaile bat sortzeko asmotan. Helburu nagusia gailuen fabrikazio arkitektura modular bat frogatzea da, non Lab-on-a-Chip prototipoak garatzeko beharrezko fase guztiak harmonizatuz, Cyclic-Olefin-Polymer termoplastikozko mikrogailu merkeak pausu gutxi batzuetan garatuko diren, hauen kalitate industriala bermatuz. Ildo horretan, mikrogailuak prototipotik produkturako trantsizio azkar, erraz, errentagarri eta arriskurik gabeen bidez lortu daitezkeenetz frogatuko da

Contact and remote breathing rate monitoring techniques: a review

ABSTRACT: Breathing rate monitoring is a must for hospitalized patients with the current coronavirus disease 2019 (COVID-19). We review in this paper recent implementations of breathing monitoring techniques, where both contact and remote approaches are presented. It is known that with non-contact monitoring, the patient is not tied to an instrument, which improves patients’ comfort and enhances the accuracy of extracted breathing activity, since the distress generated by a contact device is avoided. Remote breathing monitoring allows screening people infected with COVID-19 by detecting abnormal respiratory patterns. However, non-contact methods show some disadvantages such as the higher set-up complexity compared to contact ones. On the other hand, many reported contact methods are mainly implemented using discrete components. While, numerous integrated solutions have been reported for non-contact techniques, such as continuous wave (CW) Doppler radar and ultrawideband (UWB) pulsed radar. These radar chips are discussed and their measured performances are summarized and compared

Low-power Wearable Healthcare Sensors

Advances in technology have produced a range of on-body sensors and smartwatches that can be used to monitor a wearer’s health with the objective to keep the user healthy. However, the real potential of such devices not only lies in monitoring but also in interactive communication with expert-system-based cloud services to offer personalized and real-time healthcare advice that will enable the user to manage their health and, over time, to reduce expensive hospital admissions. To meet this goal, the research challenges for the next generation of wearable healthcare devices include the need to offer a wide range of sensing, computing, communication, and human–computer interaction methods, all within a tiny device with limited resources and electrical power. This Special Issue presents a collection of six papers on a wide range of research developments that highlight the specific challenges in creating the next generation of low-power wearable healthcare sensors

Cumulative index to NASA Tech Briefs, 1986-1990, volumes 10-14

Tech Briefs are short announcements of new technology derived from the R&D activities of the National Aeronautics and Space Administration. These briefs emphasize information considered likely to be transferrable across industrial, regional, or disciplinary lines and are issued to encourage commercial application. This cumulative index of Tech Briefs contains abstracts and four indexes (subject, personal author, originating center, and Tech Brief number) and covers the period 1986 to 1990. The abstract section is organized by the following subject categories: electronic components and circuits, electronic systems, physical sciences, materials, computer programs, life sciences, mechanics, machinery, fabrication technology, and mathematics and information sciences

NASA Tech Briefs, December 1989

Topics include: Electronic Components and Circuits. Electronic Systems, Physical Sciences, Materials, Computer Programs, Mechanics, Machinery, Fabrication Technology, Mathematics and Information Sciences, and Life Sciences

MEMS Accelerometers

Micro-electro-mechanical system (MEMS) devices are widely used for inertia, pressure, and ultrasound sensing applications. Research on integrated MEMS technology has undergone extensive development driven by the requirements of a compact footprint, low cost, and increased functionality. Accelerometers are among the most widely used sensors implemented in MEMS technology. MEMS accelerometers are showing a growing presence in almost all industries ranging from automotive to medical. A traditional MEMS accelerometer employs a proof mass suspended to springs, which displaces in response to an external acceleration. A single proof mass can be used for one- or multi-axis sensing. A variety of transduction mechanisms have been used to detect the displacement. They include capacitive, piezoelectric, thermal, tunneling, and optical mechanisms. Capacitive accelerometers are widely used due to their DC measurement interface, thermal stability, reliability, and low cost. However, they are sensitive to electromagnetic field interferences and have poor performance for high-end applications (e.g., precise attitude control for the satellite). Over the past three decades, steady progress has been made in the area of optical accelerometers for high-performance and high-sensitivity applications but several challenges are still to be tackled by researchers and engineers to fully realize opto-mechanical accelerometers, such as chip-scale integration, scaling, low bandwidth, etc

Investigating Forward Flight Multirotor Wind Tunnel Testing in a 3-by 4-foot Wind Tunnel

Investigation of complex multirotor aerodynamic phenomena via wind tunnel experimentation is becoming extremely important with the rapid progress in advanced distributed propulsion VTOL concepts. Much of this experimentation is being performed in large, highly advanced tunnels. However, the proliferation of this class of vehicles extends to small aircraft used by small businesses, universities, and hobbyists without ready access to this level of test facility. Therefore, there is a need to investigate whether multirotor vehicles can be adequately tested in smaller wind tunnel facilities. A test rig for a 2.82-pound quadcopter was developed to perform powered testing in the Cal Poly Aerospace Department’s Low Speed Wind Tunnel, equipped with a 3-foot tall by 4-foot wide test section. The results were compared to data from similar tests performed in the U.S. Army 7-by 10-ft Wind Tunnel at NASA Ames. The two data sets did not show close agreement in absolute terms but demonstrated similar trends. Due to measurement uncertainties, the contribution of wind tunnel interference effects to this discrepancy in measurements was not able to be properly quantified, but is likely a major contributor. Flow visualization results demonstrated that tunnel interference effects can likely be minimized by testing at high tunnel speeds with the vehicle pitched 10-degrees or more downward. Suggestions towards avoiding the pitfalls inherent to multirotor wind tunnel testing are provided. Additionally, a modified form of the conventional lift-to-drag ratio is presented as a metric of electric multirotor aerodynamic efficiency

NASA Tech Briefs, February 1987

Topics include: NASA TU Services; New Product Ideas; Electronic Components and Circuits; Electronic Systems; Physical Sciences; Materials; Computer Programs; Mechanics; Fabrication Technology; Machinery; Mathematics and Information Sciences; Life Sciences