Analyzing the EEG Signals in Order to Estimate the Depth of Anesthesia using Wavelet and Fuzzy Neural Networks

Estimating depth of Anesthesia in patients with the objective to administer the right dosage of drug has always attracted the attention of specialists. To study Anesthesia, researchers analyze brain waves since this is the place which is directly affected by the drug. This study aimed to estimate the depth of Anesthesia using electroencephalogram (EGG) signals, wavelet transform, and adaptive Neuro Fuzzy inference system (ANFIS). ANFIS can estimate the depth of Anesthesia with high accuracy. A set of EEG signals regarding consciousness, moderate Anesthesia, deep Anesthesia, and iso-electric point were collected from the American Society of Anesthesiologists (ASA) and PhysioNet. First, the extracted features were combined using wavelet and spectral analysis after which the target features were selected. Later, the features were classified into four categories. The results obtained revealed that the accuracy of the proposed method was 98.45%. Since the visual analysis of EEG signals is difficult, the proposed method can significantly help anesthesiologists estimate the depth of Anesthesia. Further, the results showed that ANFIS could significantly increase the accuracy of Anesthesia depth estimation. Finally, the system was deemed to be advantageous since it was also capable of updating in real-time situations as well

Fuzzy logic: A “simple” solution for complexities in neurosciences?

Background: Fuzzy logic is a multi-valued logic which is similar to human thinking and interpretation. It has the potential of combining human heuristics into computer-assisted decision making, which is applicable to individual patients as it takes into account all the factors and complexities of individuals. Fuzzy logic has been applied in all disciplines of medicine in some form and recently its applicability in neurosciences has also gained momentum.Methods: This review focuses on the use of this concept in various branches of neurosciences including basic neuroscience, neurology, neurosurgery, psychiatry and psychology.Results: The applicability of fuzzy logic is not limited to research related to neuroanatomy, imaging nerve fibers and understanding neurophysiology, but it is also a sensitive and specific tool for interpretation of EEGs, EMGs and MRIs and an effective controller device in intensive care units. It has been used for risk stratification of stroke, diagnosis of different psychiatric illnesses and even planning neurosurgical procedures.Conclusions: In the future, fuzzy logic has the potential of becoming the basis of all clinical decision making and our understanding of neurosciences

Real-Time Depth of Anaesthesia Assessment Based on Hybrid Statistical Features of EEG

This paper proposed a new depth of anaesthesia (DoA) index for the real-time assessment of DoA using electroencephalography (EEG). In the proposed new DoA index, a wavelet transform threshold was applied to denoise raw EEG signals, and five features were extracted to construct classification models. Then, the Gaussian process regression model was employed for real-time assessment of anaesthesia states. The proposed real-time DoA index was implemented using a sliding window technique and validated using clinical EEG data recorded with the most popular commercial DoA product Bispectral Index monitor (BIS). The results are evaluated using the correlation coefficients and Bland–Altman methods. The outcomes show that the highest and the average correlation coefficients are 0.840 and 0.814, respectively, in the testing dataset. Meanwhile, the scatter plot of Bland–Altman shows that the agreement between BIS and the proposed index is 94.91%. In contrast, the proposed index is free from the electromyography (EMG) effect and surpasses the BIS performance when the signal quality indicator (SQI) is lower than 15, as the proposed index can display high correlation and reliable assessment results compared with clinic observations

Depth Analysis of Anesthesia Using EEG Signals via Time Series Feature Extraction and Machine Learning

Data Availability Statement: Data presented in the paper are available on request from the corresponding author J.-S.S.Copyright © 2023 by the authors. The term “anesthetic depth” refers to the extent to which a general anesthetic agent sedates the central nervous system with specific strength concentration at which it is delivered. The depth level of anesthesia plays a crucial role in determining surgical complications, and it is imperative to keep the depth levels of anesthesia under control to perform a successful surgery. This study used electroencephalography (EEG) signals to predict the depth levels of anesthesia. Traditional preprocessing methods such as signal decomposition and model building using deep learning were used to classify anesthetic depth levels. This paper proposed a novel approach to classify the anesthesia levels based on the concept of time series feature extraction, by finding out the relation between EEG signals and the bi-spectral Index over a period of time. Time series feature extraction on basis of scalable hypothesis tests were performed to extract features by analyzing the relation between the EEG signals and Bi-Spectral Index, and machine learning models such as support vector classifier, XG boost classifier, gradient boost classifier, decision trees and random forest classifier are used to train the features and predict the depth level of anesthesia. The best-trained model was random forest, which gives an accuracy of 83%. This provides a platform to further research and dig into time series-based feature extraction in this area.Ministry of Science and Technology, Taiwan (grant number: MOST 107-2221-E-155-009-MY2)

A combinatorial deep learning structure for precise depth of anesthesia estimation from EEG signals

Electroencephalography (EEG) is commonly used to measure the depth of anesthesia (DOA) because EEG reflects surgical pain and state of the brain. However, precise and real-time estimation of DOA index for painful surgical operations is challenging due to problems such as postoperative complications and accidental awareness. To tackle these problems, we propose a new combinatorial deep learning structure involving convolutional neural networks (inspired by the inception module), bidirectional long short-term memory, and an attention layer. The proposed model uses the EEG signal to continuously predicts the bispectral index (BIS). It is trained over a large dataset, mostly from those under general anesthesia with few cases receiving sedation/analgesia and spinal anesthesia. Despite the imbalance distribution of BIS values in different levels of anesthesia, our proposed structure achieves convincing root mean square error of 5.59 ± 1.04 and mean absolute error of 4.3 ± 0.87, as well as improvement in area under the curve of 15% on average, which surpasses state-of-the-art DOA estimation methods. The DOA values are also discretized into four levels of anesthesia and the results demonstrate strong inter-subject classification accuracy of 88.7% that outperforms the conventional methods

Advanced Signal Processing and Control in Anaesthesia

This thesis comprises three major stages: classification of depth of anaesthesia (DOA); modelling a typical patient’s behaviour during a surgical procedure; and control of DOAwith simultaneous administration of propofol and remifentanil. Clinical data gathered in theoperating theatre was used in this project. Multiresolution wavelet analysis was used to extract meaningful features from the auditory evoked potentials (AEP). These features were classified into different DOA levels using a fuzzy relational classifier (FRC). The FRC uses fuzzy clustering and fuzzy relational composition. The FRC had a good performance and was able to distinguish between the DOA levels. A hybrid patient model was developed for the induction and maintenance phase of anaesthesia. An adaptive network-based fuzzy inference system was used to adapt Takagi-Sugeno-Kang (TSK) fuzzy models relating systolic arterial pressure (SAP), heart rate (HR), and the wavelet extracted AEP features with the effect concentrations of propofol and remifentanil. The effect of surgical stimuli on SAP and HR, and the analgesic properties of remifentanil were described by Mamdani fuzzy models, constructed with anaesthetist cooperation. The model proved to be adequate, reflecting the effect of drugs and surgical stimuli. A multivariable fuzzy controller was developed for the simultaneous administration of propofol and remifentanil. The controller is based on linguistic rules that interact with three decision tables, one of which represents a fuzzy PI controller. The infusion rates of the two drugs are determined according to the DOA level and surgical stimulus. Remifentanil is titrated according to the required analgesia level and its synergistic interaction with propofol. The controller was able to adequately achieve and maintain the target DOA level, under different conditions. Overall, it was possible to model the interaction between propofol and remifentanil, and to successfully use this model to develop a closed-loop system in anaesthesia

Improving Access and Mental Health for Youth Through Virtual Models of Care

The overall objective of this research is to evaluate the use of a mobile health smartphone application (app) to improve the mental health of youth between the ages of 14–25 years, with symptoms of anxiety/depression. This project includes 115 youth who are accessing outpatient mental health services at one of three hospitals and two community agencies. The youth and care providers are using eHealth technology to enhance care. The technology uses mobile questionnaires to help promote self-assessment and track changes to support the plan of care. The technology also allows secure virtual treatment visits that youth can participate in through mobile devices. This longitudinal study uses participatory action research with mixed methods. The majority of participants identified themselves as Caucasian (66.9%). Expectedly, the demographics revealed that Anxiety Disorders and Mood Disorders were highly prevalent within the sample (71.9% and 67.5% respectively). Findings from the qualitative summary established that both staff and youth found the software and platform beneficial

Developing artificial intelligence models for classification of brain disorder diseases based on statistical techniques

The Abstract is currently unavailable, due to the thesis being under Embargo

The Impact of Digital Technologies on Public Health in Developed and Developing Countries

This open access book constitutes the refereed proceedings of the 18th International Conference on String Processing and Information Retrieval, ICOST 2020, held in Hammamet, Tunisia, in June 2020.* The 17 full papers and 23 short papers presented in this volume were carefully reviewed and selected from 49 submissions. They cover topics such as: IoT and AI solutions for e-health; biomedical and health informatics; behavior and activity monitoring; behavior and activity monitoring; and wellbeing technology. *This conference was held virtually due to the COVID-19 pandemic

Epilepsy

With the vision of including authors from different parts of the world, different educational backgrounds, and offering open-access to their published work, InTech proudly presents the latest edited book in epilepsy research, Epilepsy: Histological, electroencephalographic, and psychological aspects. Here are twelve interesting and inspiring chapters dealing with basic molecular and cellular mechanisms underlying epileptic seizures, electroencephalographic findings, and neuropsychological, psychological, and psychiatric aspects of epileptic seizures, but non-epileptic as well