Analytical modelling of the effect of noise on the terahertz in-vivo communication channel for body-centric nano-networks

The paper presents an analytical model of the terahertz (THz) communication channel (0.1 - 10 THz) for in-vivo nano-networks by considering the effect of noise on link quality and information rate. The molecular absorption noise model for in-vivo nano-networks is developed based on the physical mechanisms of the noise present in the medium, which takes into account both the radiation of the medium and the molecular absorption from the transmitted signal. The signal-to-noise ratio (SNR) of the communication channel is investigated for different power allocation schemes and the maximum achievable information rate is studied to explore the potential of THz communication inside the human body. The obtained results show that the information rate is inversely proportional to the transmission distance. Based on the studies on channel performance, it can be concluded that the achievable transmission distance of in-vivo THz nano-networks should be restrained to approximately 2 mm maximum, while the operation band of in-vivo THz nano-networks should be limited to the lower band of the THz band. This motivates the utilisation of hierarchical/cooperative networking concepts and hybrid communication techniques using molecular and electromagnetic methods for future body-centric nano-networks

The Evolution of Cell Communication: The Road not Taken.

In the post-genomic era the complex problem of evolutionary biology can be tackled from the top-down, the bottom-up, or from the middle-out. Given the emergent and contingent nature of this process, we have chosen to take the latter approach, both as a mechanistic link to developmental biology and as a rational means of identifying signaling mechanisms based on their functional genomic significance. Using this approach, we have been able to configure a working model for lung evolution by reverse-engineering lung surfactant from the mammalian lung to the swim bladder of fish. Based on this archetypal cell-molecular model, we have reduced evolutionary biology to cell communication, starting with unicellular organisms communicating with the environment, followed by cell-cell communication to generate metazoa, culminating in the communication of genetic information between generations, i.e. reproduction. This model predicts the evolution of physiologic systems-including development, homeostasis, disease, regeneration/repair, and aging- as a logical consequence of biology reducing entropy. This approach provides a novel and robust way of formulating refutable, testable hypotheses to determine the ultimate origins and first principles of physiology, providing candidate genes for phenotypes hypothesized to have mediated evolutionary changes in structure and/or function. Ultimately, it will form the basis for predictive medicine and molecular bioethics, rather than merely showing associations between genes and pathology, which is an unequivocal Just So Story. In this new age of genomics, our reach must exceed our grasp

Multi-Scale Stochastic Simulation for Diffusive Molecular Communication

Recently, hybrid models have emerged that combine microscopic and mesoscopic regimes in a single stochastic reaction-diffusion simulation. Microscopic simulations track every individual molecule and are generally more accurate. Mesoscopic simulations partition the environment into subvolumes, track when molecules move between adjacent subvolumes, and are generally more computationally efficient. In this paper, we present the foundation of a multi-scale stochastic simulator from the perspective of molecular communication, for both mesoscopic and hybrid models, where we emphasize simulation accuracy at the receiver and efficiency in regions that are far from the communication link. Our multi-scale models use subvolumes of different sizes, between which we derive the diffusion event transition rate. Simulation results compare the accuracy and efficiency of traditional approaches with that of a regular hybrid method and with those of our proposed multi-scale methods.Comment: 7 pages, 2 tables, 6 figures. Will be presented at the 2015 IEEE International Conference on Communications (ICC) in June 201