3,321 research outputs found

    Exploring missing heritability in neurodevelopmental disorders:Learning from regulatory elements

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    In this thesis, I aimed to solve part of the missing heritability in neurodevelopmental disorders, using computational approaches. Next to the investigations of a novel epilepsy syndrome and investigations aiming to elucidate the regulation of the gene involved, I investigated and prioritized genomic sequences that have implications in gene regulation during the developmental stages of human brain, with the goal to create an atlas of high confidence non-coding regulatory elements that future studies can assess for genetic variants in genetically unexplained individuals suffering from neurodevelopmental disorders that are of suspected genetic origin

    Serverless Strategies and Tools in the Cloud Computing Continuum

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    Tesis por compendio[ES] En los últimos años, la popularidad de la computación en nube ha permitido a los usuarios acceder a recursos de cómputo, red y almacenamiento sin precedentes bajo un modelo de pago por uso. Esta popularidad ha propiciado la aparición de nuevos servicios para resolver determinados problemas informáticos a gran escala y simplificar el desarrollo y el despliegue de aplicaciones. Entre los servicios más destacados en los últimos años se encuentran las plataformas FaaS (Función como Servicio), cuyo principal atractivo es la facilidad de despliegue de pequeños fragmentos de código en determinados lenguajes de programación para realizar tareas específicas en respuesta a eventos. Estas funciones son ejecutadas en los servidores del proveedor Cloud sin que los usuarios se preocupen de su mantenimiento ni de la gestión de su elasticidad, manteniendo siempre un modelo de pago por uso de grano fino. Las plataformas FaaS pertenecen al paradigma informático conocido como Serverless, cuyo propósito es abstraer la gestión de servidores por parte de los usuarios, permitiéndoles centrar sus esfuerzos únicamente en el desarrollo de aplicaciones. El problema del modelo FaaS es que está enfocado principalmente en microservicios y tiende a tener limitaciones en el tiempo de ejecución y en las capacidades de computación (por ejemplo, carece de soporte para hardware de aceleración como GPUs). Sin embargo, se ha demostrado que la capacidad de autoaprovisionamiento y el alto grado de paralelismo de estos servicios pueden ser muy adecuados para una mayor variedad de aplicaciones. Además, su inherente ejecución dirigida por eventos hace que las funciones sean perfectamente adecuadas para ser definidas como pasos en flujos de trabajo de procesamiento de archivos (por ejemplo, flujos de trabajo de computación científica). Por otra parte, el auge de los dispositivos inteligentes e integrados (IoT), las innovaciones en las redes de comunicación y la necesidad de reducir la latencia en casos de uso complejos han dado lugar al concepto de Edge computing, o computación en el borde. El Edge computing consiste en el procesamiento en dispositivos cercanos a las fuentes de datos para mejorar los tiempos de respuesta. La combinación de este paradigma con la computación en nube, formando arquitecturas con dispositivos a distintos niveles en función de su proximidad a la fuente y su capacidad de cómputo, se ha acuñado como continuo de la computación en la nube (o continuo computacional). Esta tesis doctoral pretende, por lo tanto, aplicar diferentes estrategias Serverless para permitir el despliegue de aplicaciones generalistas, empaquetadas en contenedores de software, a través de los diferentes niveles del continuo computacional. Para ello, se han desarrollado múltiples herramientas con el fin de: i) adaptar servicios FaaS de proveedores Cloud públicos; ii) integrar diferentes componentes software para definir una plataforma Serverless en infraestructuras privadas y en el borde; iii) aprovechar dispositivos de aceleración en plataformas Serverless; y iv) facilitar el despliegue de aplicaciones y flujos de trabajo a través de interfaces de usuario. Además, se han creado y adaptado varios casos de uso para evaluar los desarrollos conseguidos.[CA] En els últims anys, la popularitat de la computació al núvol ha permès als usuaris accedir a recursos de còmput, xarxa i emmagatzematge sense precedents sota un model de pagament per ús. Aquesta popularitat ha propiciat l'aparició de nous serveis per resoldre determinats problemes informàtics a gran escala i simplificar el desenvolupament i desplegament d'aplicacions. Entre els serveis més destacats en els darrers anys hi ha les plataformes FaaS (Funcions com a Servei), el principal atractiu de les quals és la facilitat de desplegament de petits fragments de codi en determinats llenguatges de programació per realitzar tasques específiques en resposta a esdeveniments. Aquestes funcions són executades als servidors del proveïdor Cloud sense que els usuaris es preocupen del seu manteniment ni de la gestió de la seva elasticitat, mantenint sempre un model de pagament per ús de gra fi. Les plataformes FaaS pertanyen al paradigma informàtic conegut com a Serverless, el propòsit del qual és abstraure la gestió de servidors per part dels usuaris, permetent centrar els seus esforços únicament en el desenvolupament d'aplicacions. El problema del model FaaS és que està enfocat principalment a microserveis i tendeix a tenir limitacions en el temps d'execució i en les capacitats de computació (per exemple, no té suport per a maquinari d'acceleració com GPU). Tot i això, s'ha demostrat que la capacitat d'autoaprovisionament i l'alt grau de paral·lelisme d'aquests serveis poden ser molt adequats per a més aplicacions. A més, la seva inherent execució dirigida per esdeveniments fa que les funcions siguen perfectament adequades per ser definides com a passos en fluxos de treball de processament d'arxius (per exemple, fluxos de treball de computació científica). D'altra banda, l'auge dels dispositius intel·ligents i integrats (IoT), les innovacions a les xarxes de comunicació i la necessitat de reduir la latència en casos d'ús complexos han donat lloc al concepte d'Edge computing, o computació a la vora. L'Edge computing consisteix en el processament en dispositius propers a les fonts de dades per millorar els temps de resposta. La combinació d'aquest paradigma amb la computació en núvol, formant arquitectures amb dispositius a diferents nivells en funció de la proximitat a la font i la capacitat de còmput, s'ha encunyat com a continu de la computació al núvol (o continu computacional). Aquesta tesi doctoral pretén, doncs, aplicar diferents estratègies Serverless per permetre el desplegament d'aplicacions generalistes, empaquetades en contenidors de programari, a través dels diferents nivells del continu computacional. Per això, s'han desenvolupat múltiples eines per tal de: i) adaptar serveis FaaS de proveïdors Cloud públics; ii) integrar diferents components de programari per definir una plataforma Serverless en infraestructures privades i a la vora; iii) aprofitar dispositius d'acceleració a plataformes Serverless; i iv) facilitar el desplegament d'aplicacions i fluxos de treball mitjançant interfícies d'usuari. A més, s'han creat i s'han adaptat diversos casos d'ús per avaluar els desenvolupaments aconseguits.[EN] In recent years, the popularity of Cloud computing has allowed users to access unprecedented compute, network, and storage resources under a pay-per-use model. This popularity led to new services to solve specific large-scale computing challenges and simplify the development and deployment of applications. Among the most prominent services in recent years are FaaS (Function as a Service) platforms, whose primary appeal is the ease of deploying small pieces of code in certain programming languages to perform specific tasks on an event-driven basis. These functions are executed on the Cloud provider's servers without users worrying about their maintenance or elasticity management, always keeping a fine-grained pay-per-use model. FaaS platforms belong to the computing paradigm known as Serverless, which aims to abstract the management of servers from the users, allowing them to focus their efforts solely on the development of applications. The problem with FaaS is that it focuses on microservices and tends to have limitations regarding the execution time and the computing capabilities (e.g. lack of support for acceleration hardware such as GPUs). However, it has been demonstrated that the self-provisioning capability and high degree of parallelism of these services can be well suited to broader applications. In addition, their inherent event-driven triggering makes functions perfectly suitable to be defined as steps in file processing workflows (e.g. scientific computing workflows). Furthermore, the rise of smart and embedded devices (IoT), innovations in communication networks and the need to reduce latency in challenging use cases have led to the concept of Edge computing. Edge computing consists of conducting the processing on devices close to the data sources to improve response times. The coupling of this paradigm together with Cloud computing, involving architectures with devices at different levels depending on their proximity to the source and their compute capability, has been coined as Cloud Computing Continuum (or Computing Continuum). Therefore, this PhD thesis aims to apply different Serverless strategies to enable the deployment of generalist applications, packaged in software containers, across the different tiers of the Cloud Computing Continuum. To this end, multiple tools have been developed in order to: i) adapt FaaS services from public Cloud providers; ii) integrate different software components to define a Serverless platform on on-premises and Edge infrastructures; iii) leverage acceleration devices on Serverless platforms; and iv) facilitate the deployment of applications and workflows through user interfaces. Additionally, several use cases have been created and adapted to assess the developments achieved.Risco Gallardo, S. (2023). Serverless Strategies and Tools in the Cloud Computing Continuum [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/202013Compendi

    Information actors beyond modernity and coloniality in times of climate change:A comparative design ethnography on the making of monitors for sustainable futures in Curaçao and Amsterdam, between 2019-2022

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    In his dissertation, Mr. Goilo developed a cutting-edge theoretical framework for an Anthropology of Information. This study compares information in the context of modernity in Amsterdam and coloniality in Curaçao through the making process of monitors and develops five ways to understand how information can act towards sustainable futures. The research also discusses how the two contexts, that is modernity and coloniality, have been in informational symbiosis for centuries which is producing negative informational side effects within the age of the Anthropocene. By exploring the modernity-coloniality symbiosis of information, the author explains how scholars, policymakers, and data-analysts can act through historical and structural roots of contemporary global inequities related to the production and distribution of information. Ultimately, the five theses propose conditions towards the collective production of knowledge towards a more sustainable planet

    Exploring missing heritability in neurodevelopmental disorders:Learning from regulatory elements

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    LIPIcs, Volume 251, ITCS 2023, Complete Volume

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    LIPIcs, Volume 251, ITCS 2023, Complete Volum

    Spectrum auctions: designing markets to benefit the public, industry and the economy

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    Access to the radio spectrum is vital for modern digital communication. It is an essential component for smartphone capabilities, the Cloud, the Internet of Things, autonomous vehicles, and multiple other new technologies. Governments use spectrum auctions to decide which companies should use what parts of the radio spectrum. Successful auctions can fuel rapid innovation in products and services, unlock substantial economic benefits, build comparative advantage across all regions, and create billions of dollars of government revenues. Poor auction strategies can leave bandwidth unsold and delay innovation, sell national assets to firms too cheaply, or create uncompetitive markets with high mobile prices and patchy coverage that stifles economic growth. Corporate bidders regularly complain that auctions raise their costs, while government critics argue that insufficient revenues are raised. The cross-national record shows many examples of both highly successful auctions and miserable failures. Drawing on experience from the UK and other countries, senior regulator Geoffrey Myers explains how to optimise the regulatory design of auctions, from initial planning to final implementation. Spectrum Auctions offers unrivalled expertise for regulators and economists engaged in practical auction design or company executives planning bidding strategies. For applied economists, teachers, and advanced students this book provides unrivalled insights in market design and public management. Providing clear analytical frameworks, case studies of auctions, and stage-by-stage advice, it is essential reading for anyone interested in designing public-interested and successful spectrum auctions

    The Application of Data Analytics Technologies for the Predictive Maintenance of Industrial Facilities in Internet of Things (IoT) Environments

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    In industrial production environments, the maintenance of equipment has a decisive influence on costs and on the plannability of production capacities. In particular, unplanned failures during production times cause high costs, unplanned downtimes and possibly additional collateral damage. Predictive Maintenance starts here and tries to predict a possible failure and its cause so early that its prevention can be prepared and carried out in time. In order to be able to predict malfunctions and failures, the industrial plant with its characteristics, as well as wear and ageing processes, must be modelled. Such modelling can be done by replicating its physical properties. However, this is very complex and requires enormous expert knowledge about the plant and about wear and ageing processes of each individual component. Neural networks and machine learning make it possible to train such models using data and offer an alternative, especially when very complex and non-linear behaviour is evident. In order for models to make predictions, as much data as possible about the condition of a plant and its environment and production planning data is needed. In Industrial Internet of Things (IIoT) environments, the amount of available data is constantly increasing. Intelligent sensors and highly interconnected production facilities produce a steady stream of data. The sheer volume of data, but also the steady stream in which data is transmitted, place high demands on the data processing systems. If a participating system wants to perform live analyses on the incoming data streams, it must be able to process the incoming data at least as fast as the continuous data stream delivers it. If this is not the case, the system falls further and further behind in processing and thus in its analyses. This also applies to Predictive Maintenance systems, especially if they use complex and computationally intensive machine learning models. If sufficiently scalable hardware resources are available, this may not be a problem at first. However, if this is not the case or if the processing takes place on decentralised units with limited hardware resources (e.g. edge devices), the runtime behaviour and resource requirements of the type of neural network used can become an important criterion. This thesis addresses Predictive Maintenance systems in IIoT environments using neural networks and Deep Learning, where the runtime behaviour and the resource requirements are relevant. The question is whether it is possible to achieve better runtimes with similarly result quality using a new type of neural network. The focus is on reducing the complexity of the network and improving its parallelisability. Inspired by projects in which complexity was distributed to less complex neural subnetworks by upstream measures, two hypotheses presented in this thesis emerged: a) the distribution of complexity into simpler subnetworks leads to faster processing overall, despite the overhead this creates, and b) if a neural cell has a deeper internal structure, this leads to a less complex network. Within the framework of a qualitative study, an overall impression of Predictive Maintenance applications in IIoT environments using neural networks was developed. Based on the findings, a novel model layout was developed named Sliced Long Short-Term Memory Neural Network (SlicedLSTM). The SlicedLSTM implements the assumptions made in the aforementioned hypotheses in its inner model architecture. Within the framework of a quantitative study, the runtime behaviour of the SlicedLSTM was compared with that of a reference model in the form of laboratory tests. The study uses synthetically generated data from a NASA project to predict failures of modules of aircraft gas turbines. The dataset contains 1,414 multivariate time series with 104,897 samples of test data and 160,360 samples of training data. As a result, it could be proven for the specific application and the data used that the SlicedLSTM delivers faster processing times with similar result accuracy and thus clearly outperforms the reference model in this respect. The hypotheses about the influence of complexity in the internal structure of the neuronal cells were confirmed by the study carried out in the context of this thesis

    2023-2024 Catalog

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    The 2023-2024 Governors State University Undergraduate and Graduate Catalog is a comprehensive listing of current information regarding:Degree RequirementsCourse OfferingsUndergraduate and Graduate Rules and Regulation

    Investigating the learning potential of the Second Quantum Revolution: development of an approach for secondary school students

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    In recent years we have witnessed important changes: the Second Quantum Revolution is in the spotlight of many countries, and it is creating a new generation of technologies. To unlock the potential of the Second Quantum Revolution, several countries have launched strategic plans and research programs that finance and set the pace of research and development of these new technologies (like the Quantum Flagship, the National Quantum Initiative Act and so on). The increasing pace of technological changes is also challenging science education and institutional systems, requiring them to help to prepare new generations of experts. This work is placed within physics education research and contributes to the challenge by developing an approach and a course about the Second Quantum Revolution. The aims are to promote quantum literacy and, in particular, to value from a cultural and educational perspective the Second Revolution. The dissertation is articulated in two parts. In the first, we unpack the Second Quantum Revolution from a cultural perspective and shed light on the main revolutionary aspects that are elevated to the rank of principles implemented in the design of a course for secondary school students, prospective and in-service teachers. The design process and the educational reconstruction of the activities are presented as well as the results of a pilot study conducted to investigate the impact of the approach on students' understanding and to gather feedback to refine and improve the instructional materials. The second part consists of the exploration of the Second Quantum Revolution as a context to introduce some basic concepts of quantum physics. We present the results of an implementation with secondary school students to investigate if and to what extent external representations could play any role to promote students’ understanding and acceptance of quantum physics as a personal reliable description of the world

    Cognitive Machine Individualism in a Symbiotic Cybersecurity Policy Framework for the Preservation of Internet of Things Integrity: A Quantitative Study

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    This quantitative study examined the complex nature of modern cyber threats to propose the establishment of cyber as an interdisciplinary field of public policy initiated through the creation of a symbiotic cybersecurity policy framework. For the public good (and maintaining ideological balance), there must be recognition that public policies are at a transition point where the digital public square is a tangible reality that is more than a collection of technological widgets. The academic contribution of this research project is the fusion of humanistic principles with Internet of Things (IoT) technologies that alters our perception of the machine from an instrument of human engineering into a thinking peer to elevate cyber from technical esoterism into an interdisciplinary field of public policy. The contribution to the US national cybersecurity policy body of knowledge is a unified policy framework (manifested in the symbiotic cybersecurity policy triad) that could transform cybersecurity policies from network-based to entity-based. A correlation archival data design was used with the frequency of malicious software attacks as the dependent variable and diversity of intrusion techniques as the independent variable for RQ1. For RQ2, the frequency of detection events was the dependent variable and diversity of intrusion techniques was the independent variable. Self-determination Theory is the theoretical framework as the cognitive machine can recognize, self-endorse, and maintain its own identity based on a sense of self-motivation that is progressively shaped by the machine’s ability to learn. The transformation of cyber policies from technical esoterism into an interdisciplinary field of public policy starts with the recognition that the cognitive machine is an independent consumer of, advisor into, and influenced by public policy theories, philosophical constructs, and societal initiatives
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