Design and Comprehensive Analysis of a Noise-Tolerant ZNN Model With Limited-Time Convergence for Time-Dependent Nonlinear Minimization

Zeroing neural network (ZNN) is a powerful tool to address the mathematical and optimization problems broadly arisen in the science and engineering areas. The convergence and robustness are always co-pursued in ZNN. However, there exists no related work on the ZNN for time-dependent nonlinear minimization that achieves simultaneously limited-time convergence and inherently noise suppression. In this article, for the purpose of satisfying such two requirements, a limited-time robust neural network (LTRNN) is devised and presented to solve time-dependent nonlinear minimization under various external disturbances. Different from the previous ZNN model for this problem either with limited-time convergence or with noise suppression, the proposed LTRNN model simultaneously possesses such two characteristics. Besides, rigorous theoretical analyses are given to prove the superior performance of the LTRNN model when adopted to solve time-dependent nonlinear minimization under external disturbances. Comparative results also substantiate the effectiveness and advantages of LTRNN via solving a time-dependent nonlinear minimization problem

Computation and Learning in High Dimensions (hybrid meeting)

The most challenging problems in science often involve the learning and accurate computation of high dimensional functions. High-dimensionality is a typical feature for a multitude of problems in various areas of science. The so-called curse of dimensionality typically negates the use of traditional numerical techniques for the solution of high-dimensional problems. Instead, novel theoretical and computational approaches need to be developed to make them tractable and to capture fine resolutions and relevant features. Paradoxically, increasing computational power may even serve to heighten this demand, since the wealth of new computational data itself becomes a major obstruction. Extracting essential information from complex problem-inherent structures and developing rigorous models to quantify the quality of information in a high-dimensional setting pose challenging tasks from both theoretical and numerical perspective. This has led to the emergence of several new computational methodologies, accounting for the fact that by now well understood methods drawing on spatial localization and mesh-refinement are in their original form no longer viable. Common to these approaches is the nonlinearity of the solution method. For certain problem classes, these methods have drastically advanced the frontiers of computability. The most visible of these new methods is deep learning. Although the use of deep neural networks has been extremely successful in certain application areas, their mathematical understanding is far from complete. This workshop proposed to deepen the understanding of the underlying mathematical concepts that drive this new evolution of computational methods and to promote the exchange of ideas emerging in various disciplines about how to treat multiscale and high-dimensional problems

Multimodal MR Prediction Models for Late-Life Depression and Treatment Response

Currently, depression diagnosis relies primarily on behavioral symptoms and signs, instead of underlying brain characteristics, and treatment is guided by trial and error instead of individual suitability associated with underlying brain characteristics. Also, previous brain-imaging studies attempting to resolve this issue have traditionally focused on mid-life depression using a single imaging modality and region-based approach, which may not fully explain the complexity of the underlying brain characteristics; especially for late-life depression. We aimed to evaluate and compare underlying brain characteristics of late-life depression diagnosis and treatment response by estimating accurate prediction models using multi-modal magnetic resonance imaging and non-imaging measures. Based on our finding, late-life depression diagnosis and treatment response predictors involve measures from different imaging modalities, which are indicative of differences in underlying brain characteristics