Application of Computational Intelligence Techniques to Process Industry Problems

In the last two decades there has been a large progress in the computational intelligence research field. The fruits of the effort spent on the research in the discussed field are powerful techniques for pattern recognition, data mining, data modelling, etc. These techniques achieve high performance on traditional data sets like the UCI machine learning database. Unfortunately, this kind of data sources usually represent clean data without any problems like data outliers, missing values, feature co-linearity, etc. common to real-life industrial data. The presence of faulty data samples can have very harmful effects on the models, for example if presented during the training of the models, it can either cause sub-optimal performance of the trained model or in the worst case destroy the so far learnt knowledge of the model. For these reasons the application of present modelling techniques to industrial problems has developed into a research field on its own. Based on the discussion of the properties and issues of the data and the state-of-the-art modelling techniques in the process industry, in this paper a novel unified approach to the development of predictive models in the process industry is presented

Machine learning in bioprocess development: From promise to practice

Fostered by novel analytical techniques, digitalization and automation, modern bioprocess development provides high amounts of heterogeneous experimental data, containing valuable process information. In this context, data-driven methods like machine learning (ML) approaches have a high potential to rationally explore large design spaces while exploiting experimental facilities most efficiently. The aim of this review is to demonstrate how ML methods have been applied so far in bioprocess development, especially in strain engineering and selection, bioprocess optimization, scale-up, monitoring and control of bioprocesses. For each topic, we will highlight successful application cases, current challenges and point out domains that can potentially benefit from technology transfer and further progress in the field of ML

Real-time monitoring device “panigraph” for bread fermentation with an Arduino-based data acquisition and management system

Monitoring and evaluating fermentative performance of sourdough used in bakery products typically involves discontinuous, destructive and costly analyses, resulting in substantial data that is expensive to exploit using conventional methods. The performance of sourdough is determined by its capacity to efficiently leaven the dough in the briefest timeframe possible, while simultaneously reducing the pH to an optimal level. This pH reduction facilitates the activity of enzymes, notably phytases, which break down phytates. Additionally, sourdough has the ability to generate ethanol, a crucial element contributing to the flavor and shelf life of the bread. A new, low-cost, non-destructive device has been developed with a system for real-time data acquisition, monitoring, visualization, as well as data processing, consolidation, and storage, thus simplifying the study of sourdough performance. Multiple specific sensors were integrated into an Arduino Uno board and placed in a connected fermentation chamber controlled by computer-installed software. The developed device enables real-time monitoring of critical parameters during sourdough fermentation. These include dough rising DRC (cm), gas release (CO2, ethanol) (ppmv or ml), pH, conductivity (uS/cm), moisture (%) and dough mass loss (g). Additionally, it measures temperature (°C), air humidity (%) and pressure (mbar) within the fermentation chamber. The device generates graphs, facilitating visual comparisons of sourdough fermentative performance. This graphical representation makes it easy to determine the end of fermentation. The developed application facilitated the management and utilization of the sourdough database. The device enables researchers to save time, reagents and equipment that are usually dedicated to such analyses. It achieves this by offering continuous and simultaneous monitoring of various sourdough fermentation parameters, allowing for an assessment of their fermenting capacity. Keywords: Sourdough, bread, fermentative capacity, data acquisition, monitorin

Modern day monitoring and control challenges outlined on an industrial-scale benchmark fermentation process

This paper outlines real-world control challenges faced by modern-day biopharmaceutical facilities through the extension of a previously developed industrial-scale penicillin fermentation simulation (IndPenSim). The extensions include the addition of a simulated Raman spectroscopy device for the purpose of developing, evaluating and implementation of advanced and innovative control solutions applicable to biotechnology facilities. IndPenSim can be operated in fixed or operator controlled mode and generates all the available on-line, off-line and Raman spectra for each batch. The capabilities of IndPenSim were initially demonstrated through the implementation of a QbD methodology utilising the three stages of the PAT framework. Furthermore, IndPenSim evaluated a fault detection algorithm to detect process faults occurring on different batches recorded throughout a yearly campaign. The simulator and all data presented here are available to download at www.industrialpenicillinsimulation.com and acts as a benchmark for researchers to analyse, improve and optimise the current control strategy implemented on this facility. Additionally, a highly valuable data resource containing 100 batches with all available process and Raman spectroscopy measurements is freely available to download. This data is highly suitable for the development of big data analytics, machine learning (ML) or artificial intelligence (AI) algorithms applicable to the biopharmaceutical industry

The role of artificial intelligence-driven soft sensors in advanced sustainable process industries: a critical review

With the predicted depletion of natural resources and alarming environmental issues, sustainable development has become a popular as well as a much-needed concept in modern process industries. Hence, manufacturers are quite keen on adopting novel process monitoring techniques to enhance product quality and process efficiency while minimizing possible adverse environmental impacts. Hardware sensors are employed in process industries to aid process monitoring and control, but they are associated with many limitations such as disturbances to the process flow, measurement delays, frequent need for maintenance, and high capital costs. As a result, soft sensors have become an attractive alternative for predicting quality-related parameters that are ‘hard-to-measure’ using hardware sensors. Due to their promising features over hardware counterparts, they have been employed across different process industries. This article attempts to explore the state-of-the-art artificial intelligence (Al)-driven soft sensors designed for process industries and their role in achieving the goal of sustainable development. First, a general introduction is given to soft sensors, their applications in different process industries, and their significance in achieving sustainable development goals. AI-based soft sensing algorithms are then introduced. Next, a discussion on how AI-driven soft sensors contribute toward different sustainable manufacturing strategies of process industries is provided. This is followed by a critical review of the most recent state-of-the-art AI-based soft sensors reported in the literature. Here, the use of powerful AI-based algorithms for addressing the limitations of traditional algorithms, that restrict the soft sensor performance is discussed. Finally, the challenges and limitations associated with the current soft sensor design, application, and maintenance aspects are discussed with possible future directions for designing more intelligent and smart soft sensing technologies to cater the future industrial needs

Modern day monitoring and control challenges outlined on an industrial-scale benchmark fermentation process

This paper outlines real-world control challenges faced by modern-day biopharmaceutical facilities through the extension of a previously developed industrial-scale penicillin fermentation simulation (IndPenSim). The extensions include the addition of a simulated Raman spectroscopy device for the purpose of developing, evaluating and implementation of advanced and innovative control solutions applicable to biotechnology facilities. IndPenSim can be operated in fixed or operator controlled mode and generates all the available on-line, off-line and Raman spectra for each batch. The capabilities of IndPenSim were initially demonstrated through the implementation of a QbD methodology utilising the three stages of the PAT framework. Furthermore, IndPenSim evaluated a fault detection algorithm to detect process faults occurring on different batches recorded throughout a yearly campaign. The simulator and all data presented here are available to download at www.industrialpenicillinsimulation.com and acts as a benchmark for researchers to analyse, improve and optimise the current control strategy implemented on this facility. Additionally, a highly valuable data resource containing 100 batches with all available process and Raman spectroscopy measurements is freely available to download. This data is highly suitable for the development of big data analytics, machine learning (ML) or artificial intelligence (AI) algorithms applicable to the biopharmaceutical industry

Layered Modeling and Simulation of Complex Biotechnological Processes - Optimizing Rhamnolipid Production by Pseudomonas aeruginosa during Cultivation in a Bioreactor

In this thesis, a model for the regulation of rhamnolipid production and data obtained from metabolic balancing were combined with a process model on a bioreactor scale. The model was used to derive an optimized process control stategy for enhanced product formation. This thesis provides a missing piece in a puzzle for knowledge-based strategies for enhanced rhamnolipid formation

Bioprocess Monitoring and Control

Process monitoring and control are fundamental to all processes; this holds especially for bioprocesses, due to their complex nature. Usually, bioprocesses deal with living cells, which have their own regulatory systems. It helps to adjust the cell to its environmental condition. This must not be the optimal condition that the cell needs to produce whatever is desired. Therefore, a close monitoring of the cell and its environment is essential to provide optimal conditions for production. Without measurement, no information of the current process state is obtained. In this book, methods and techniques are provided for the monitoring and control of bioprocesses. From new developments for sensors, the application of spectroscopy and modelling approaches, the estimation and observer implementation for ethanol production and the development and scale-up of various bioprocesses and their closed loop control information are presented. The processes discussed here are very diverse. The major applications are cultivation processes, where microorganisms were grown, but also an incubation process of bird’s eggs, as well as an indoor climate control for humans, will be discussed. Altogether, in 12 chapters, nine original research papers and three reviews are presented

Applications of Emerging Smart Technologies in Farming Systems: A Review

The future of farming systems depends mainly on adopting innovative intelligent and smart technologies The agricultural sector s growth and progress are more critical to human survival than any other industry Extensive multidisciplinary research is happening worldwide for adopting intelligent technologies in farming systems Nevertheless when it comes to handling realistic challenges in making autonomous decisions and predictive solutions in farming applications of Information Communications Technologies ICT need to be utilized more Information derived from data worked best on year-to-year outcomes disease risk market patterns prices or customer needs and ultimately facilitated farmers in decision-making to increase crop and livestock production Innovative technologies allow the analysis and correlation of information on seed quality soil types infestation agents weather conditions etc This review analysis highlights the concept methods and applications of various futuristic cognitive innovative technologies along with their critical roles played in different aspects of farming systems like Artificial Intelligence AI IoT Neural Networks utilization of unmanned vehicles UAV Big data analytics Blok chain technology et