9,807 research outputs found
Prediction of photoperiodic regulators from quantitative gene circuit models
Photoperiod sensors allow physiological adaptation to the changing seasons. The external coincidence hypothesis postulates that a light-responsive regulator is modulated by a circadian rhythm. Sufficient data are available to test this quantitatively in plants, though not yet in animals. In Arabidopsis, the clock-regulated genes CONSTANS (CO) and FLAVIN, KELCH, F-BOX (FKF1) and their lightsensitive proteins are thought to form an external coincidence sensor. We use 40 timeseries of molecular data to model the integration of light and timing information by CO, its target gene FLOWERING LOCUS T (FT), and the circadian clock. Among other predictions, the models show that FKF1 activates FT. We demonstrate experimentally that this effect is independent of the known activation of CO by FKF1, thus we locate a major, novel controller of photoperiodism. External coincidence is part of a complex photoperiod sensor: modelling makes this complexity explicit and may thus contribute to crop improvement
International conference on software engineering and knowledge engineering: Session chair
The Thirtieth International Conference on Software Engineering and Knowledge Engineering (SEKE 2018) will be held at the Hotel Pullman, San Francisco Bay, USA, from July 1 to July 3, 2018. SEKE2018 will also be dedicated in memory of Professor Lofti Zadeh, a great scholar, pioneer and leader in fuzzy sets theory and soft computing.
The conference aims at bringing together experts in software engineering and knowledge engineering to discuss on relevant results in either software engineering or knowledge engineering or both. Special emphasis will be put on the transference of methods between both domains. The theme this year is soft computing in software engineering & knowledge engineering. Submission of papers and demos are both welcome
How are Statistical Journals linked? A Network Analysis
The exploratory analysis developed in this paper relies on the hypothesis that each editor possesses some power in the definition of the editorial policy of her journal. Consequently if the same scholar sits on the board of two journals, those journals could have some common elements in their editorial policies. The proximity of the editorial policies of two scientific journals can be assessed by the number of common editors sitting on their boards. A database of all editors of the journals classified as “Statistics & Probability” in the Journal of Citation Report by ISI-Thomson is used. The structure of the network generated by the interlocking editorship is explored applying the instruments of network analysis. Evidences are found of a very compact network. This is interpreted as the result of a common perspective about the appropriate methods for investigating the problems and constructing the theories in the domain of statisticsNetworks; Journals; Editorial boards; Interlocking editorship; Statisticians
Creep stability of the proposed AIDA mission target 65803 Didymos: I. Discrete cohesionless granular physics model
As the target of the proposed Asteroid Impact & Deflection Assessment (AIDA)
mission, the near-Earth binary asteroid 65803 Didymos represents a special
class of binary asteroids, those whose primaries are at risk of rotational
disruption. To gain a better understanding of these binary systems and to
support the AIDA mission, this paper investigates the creep stability of the
Didymos primary by representing it as a cohesionless self-gravitating granular
aggregate subject to rotational acceleration. To achieve this goal, a
soft-sphere discrete element model (SSDEM) capable of simulating granular
systems in quasi-static states is implemented and a quasi-static spin-up
procedure is carried out. We devise three critical spin limits for the
simulated aggregates to indicate their critical states triggered by reshaping
and surface shedding, internal structural deformation, and shear failure,
respectively. The failure condition and mode, and shear strength of an
aggregate can all be inferred from the three critical spin limits. The effects
of arrangement and size distribution of constituent particles, bulk density,
spin-up path, and interparticle friction are numerically explored. The results
show that the shear strength of a spinning self-gravitating aggregate depends
strongly on both its internal configuration and material parameters, while its
failure mode and mechanism are mainly affected by its internal configuration.
Additionally, this study provides some constraints on the possible physical
properties of the Didymos primary based on observational data and proposes a
plausible formation mechanism for this binary system. With a bulk density
consistent with observational uncertainty and close to the maximum density
allowed for the asteroid, the Didymos primary in certain configurations can
remain geo-statically stable without including cohesion.Comment: 66 pages, 24 figures, submitted to Icarus on 25/Aug/201
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