Using reaction-diffusion equations to model and simulate the interaction of bone cells with electrical stimulation

Electrical stimulation is being used clinically to promote bone ingrowth on implant surfaces and bone healing after complicated fractures. The osseointegration of biomaterials in bone requires complex biological interactions between different bone cells types and electrical stimulation. This work addresses modeling and simulation of the interactions between bone cells and electrical stimulation.Die elektrische Stimulation wird klinisch eingesetzt, um das Einwachsen von Knochen auf Implantatoberflächen sowie die Knochenheilung nach komplizierten Frakturen zu fördern. Die Osseointegration von Biomaterialien im Knochen unterliegt dabei komplexen biologischen Interaktionen zwischen Knochenzellen und der elektrischen Stimulation. Im Rahmen dieser Arbeit erfolgte daher die Modellierung und Simulation der Wechselwirkungen zwischen Knochenzellen und elektrischer Stimulation mit Hilfe eines konstruierten In-vitro-Systems, um elektrotaktische Experimente an Osteoblasten durchzuführen

Bioceramic Composites

Biomaterials—the materials used for the manufacturing of medical devices— are part of everyday life. Each one of us has likely had the experience of visting a dentist’s office, where a number of biomaterials are used temporarily or permanently in the mouth. Devices that are more complex are used for to support, heal, or replace living tissues or organs in the body that are suffering or compromised by different conditions. The materials used in their construction are metals and metallic alloys, polymers—ranging from elastomers to adhesives—and ceramics.Within these three cases, there are materials that are inert in the living environment, that perform an active function, or that are dissolved and resorbed by the metabolic pathways. Biomaterials are the outcome of a dynamic field of research that is driven by a growing demand and by the competition among the manufacturers of medical devices, with innovations improving the performance of existing devices and that contribute to the development of new ones. The collection of papers forming this volume have one particular class of of biomaterial in common, ceramic (bioceramic) composites, which as so far been used in applications such as orthopaedic joint replacement as well as in dental implants and restorations and that is being intensively investigated for bone regeneration applications. Today’s bioceramic composites (alumina–zirconia) are the golden standard in joint replacements. Several manufracturers have proposed different zirconia–alumina composites for use in hip, knee, and shoulder joint replacements, with several other innovative devices also being under study. In addition, bioceramic composites with innovative compositions are under development and will be on the market in years to come. Something that is especially interesting is the application of bioceramic composites in the regeneration of bone tissues. Research has devoted special attention to the doping of well-known materials (i.e., calcium phosphates and silicates) with bioactive ions, aiming to enhance the osteogenic ability and bioresorbability of man-made grafts. Moreover, high expectations rely on hybrid biopolymer/ceramic materials that mimic the complex composition and multiscale structure of bone tissue

Hydroxyapatite Based Material: Natural Resources, Synthesis Methods, 3D Print Filament Fabrication, and Filament Filler

Hydroxyapatite is a biomaterial that has been recognized in terms of hard tissue engineering due to its similarity in composition to bioapatite. Moreover, abundant resources and diverse synthesis methods make hydroxyapatite easy to produce. The application in terms of 3D print-based network engineering is also being intensively explored due to hydroxyapatite scaffold fabrication process flexibility. In this review, various hydroxyapatite from natural sources, synthesis methods, hydroxyapatite-based 3D print filament fabrication techniques, as well as fillers used in the production of filaments are discussed

Book of Abstracts 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and 3rd Conference on Imaging and Visualization

In this edition, the two events will run together as a single conference, highlighting the strong connection with the Taylor & Francis journals: Computer Methods in Biomechanics and Biomedical Engineering (John Middleton and Christopher Jacobs, Eds.) and Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization (JoãoManuel R.S. Tavares, Ed.). The conference has become a major international meeting on computational biomechanics, imaging andvisualization. In this edition, the main program includes 212 presentations. In addition, sixteen renowned researchers will give plenary keynotes, addressing current challenges in computational biomechanics and biomedical imaging. In Lisbon, for the first time, a session dedicated to award the winner of the Best Paper in CMBBE Journal will take place. We believe that CMBBE2018 will have a strong impact on the development of computational biomechanics and biomedical imaging and visualization, identifying emerging areas of research and promoting the collaboration and networking between participants. This impact is evidenced through the well-known research groups, commercial companies and scientific organizations, who continue to support and sponsor the CMBBE meeting series. In fact, the conference is enriched with five workshops on specific scientific topics and commercial software.info:eu-repo/semantics/draf

In Vitro Simulation of Pathological Bone Conditions to Predict Clinical Outcome of Bone Tissue Engineered Materials

According to the Centers for Disease Control, the geriatric population of ≥65 years of age will increase to 51.5 million in 2020; 40% of white women and 13% of white men will be at risk for fragility fractures or fractures sustained under normal stress and loading conditions due to bone disease, leading to hospitalization and surgical treatment. Fracture management strategies can be divided into pharmaceutical therapy, surgical intervention, and tissue regeneration for fracture prevention, fracture stabilization, and fracture site regeneration, respectively. However, these strategies fail to accommodate the pathological nature of fragility fractures, leading to unwanted side effects, implant failures, and non-unions. Compromised innate bone healing reactions of patients with bone diseases are exacerbated with protective bone therapy. Once these patients sustain a fracture, bone healing is a challenge, especially when fracture stabilization is unsuccessful. Traditional stabilizing screw and plate systems were designed with emphasis on bone mechanics rather than biology. Bone grafts are often used with fixation devices to provide skeletal continuity at the fracture gap. Current bone grafts include autologous bone tissue and donor bone tissue; however, the quality and quantity demanded by fragility fractures sustained by high-risk geriatric patients and patients with bone diseases are not met. Consequently, bone tissue engineering strategies are advancing towards functionalized bone substitutes to provide fracture reconstruction while effectively mediating bone healing in normal and diseased fracture environments. In order to target fragility fractures, fracture management strategies should be tailored to allow bone regeneration and fracture stabilization with bioactive bone substitutes designed for the pathological environment. The clinical outcome of these materials must be predictable within various disease environments. Initial development of a targeted treatment strategy should focus on simulating, in vitro, a physiological bone environment to predict clinical effectiveness of engineered bone and understand cellular responses due to the proposed agents and bioactive scaffolds. An in vitro test system can be the necessary catalyst to reduce implant failures and non-unions in fragility fractures

Progenitor cells in auricular cartilage demonstrate promising cartilage regenerative potential in 3D hydrogel culture

The reconstruction of auricular deformities is a very challenging surgical procedure that could benefit from a tissue engineering approach. Nevertheless, a major obstacle is presented by the acquisition of sufficient amounts of autologous cells to create a cartilage construct the size of the human ear. Extensively expanded chondrocytes are unable to retain their phenotype, while bone marrow-derived mesenchymal stromal cells (MSC) show endochondral terminal differentiation by formation of a calcified matrix. The identification of tissue-specific progenitor cells in auricular cartilage, which can be expanded to high numbers without loss of cartilage phenotype, has great prospects for cartilage regeneration of larger constructs. This study investigates the largely unexplored potential of auricular progenitor cells for cartilage tissue engineering in 3D hydrogels

Biomaterials for Bone Tissue Engineering 2020

This book presents recent advances in the field of bone tissue engineering, including molecular insights, innovative biomaterials with regenerative properties (e.g., osteoinduction and osteoconduction), and physical stimuli to enhance bone regeneration