Network destabilization and transition in depression : new methods for studying the dynamics of therapeutic change

The science of dynamic systems is the study of pattern formation and system change. Dynamic systems theory can provide a useful framework for understanding the chronicity of depression and its treatment. We propose a working model of therapeutic change with potential to organize findings from psychopathology and treatment research, suggest new ways to study change, facilitate comparisons across studies, and stimulate treatment innovation. We describe a treatment for depression that we developed to apply principles from dynamic systems theory and then present a program of research to examine the utility of this application. Recent methodological and technological developments are also discussed to further advance the search for mechanisms of therapeutic change

Hyperconnectivity is a fundamental response to neurological disruption

In the cognitive and clinical neurosciences, the past decade has been marked by dramatic growth in a literature examining brain "connectivity" using noninvasive methods. We offer a critical review of the blood oxygen level dependent functional MRI (BOLD fMRI) literature examining neural connectivity changes in neurological disorders with focus on brain injury and dementia. The goal is to demonstrate that there are identifiable shifts in local and large-scale network connectivity that can be predicted by the degree of pathology. We anticipate that the most common network response to neurological insult is hyperconnectivity but that this response depends upon demand and resource availability

Analysis of the structure of time-frequency information in electromagnetic brain signals

This thesis encompasses methodological developments and experimental work aimed at revealing information contained in time, frequency, and time–frequency representations of electromagnetic, specifically magnetoencephalographic, brain signals. The work can be divided into six endeavors. First, it was shown that sound slopes increasing in intensity from undetectable to audible elicit event-related responses (ERRs) that predict behavioral sound detection. This provides an opportunity to use non-invasive brain measures in hearing assessment. Second, the actively debated generation mechanism of ERRs was examined using novel analysis techniques, which showed that auditory stimulation did not result in phase reorganization of ongoing neural oscillations, and that processes additive to the oscillations accounted for the generation of ERRs. Third, the prerequisites for the use of continuous wavelet transform in the interrogation of event-related brain processes were established. Subsequently, it was found that auditory stimulation resulted in an intermittent dampening of ongoing oscillations. Fourth, information on the time–frequency structure of ERRs was used to reveal that, depending on measurement condition, amplitude differences in averaged ERRs were due to changes in temporal alignment or in amplitudes of the single-trial ERRs. Fifth, a method that exploits mutual information of spectral estimates obtained with several window lengths was introduced. It allows the removal of frequency-dependent noise slopes and the accentuation of spectral peaks. Finally, a two-dimensional statistical data representation was developed, wherein all frequency components of a signal are made directly comparable according to spectral distribution of their envelope modulations by using the fractal property of the wavelet transform. This representation reveals noise buried processes and describes their envelope behavior. These examinations provide for two general conjectures. The stability of structures, or the level of stationarity, in a signal determines the appropriate analysis method and can be used as a measure to reveal processes that may not be observable with other available analysis approaches. The results also indicate that transient neural activity, reflected in ERRs, is a viable means of representing information in the human brain.reviewe