Multi-Scale Simulation Modeling for Prevention and Public Health Management of Diabetes in Pregnancy and Sequelae

Diabetes in pregnancy (DIP) is an increasing public health priority in the Australian Capital Territory, particularly due to its impact on risk for developing Type 2 diabetes. While earlier diagnostic screening results in greater capacity for early detection and treatment, such benefits must be balanced with the greater demands this imposes on public health services. To address such planning challenges, a multi-scale hybrid simulation model of DIP was built to explore the interaction of risk factors and capture the dynamics underlying the development of DIP. The impact of interventions on health outcomes at the physiological, health service and population level is measured. Of particular central significance in the model is a compartmental model representing the underlying physiological regulation of glycemic status based on beta-cell dynamics and insulin resistance. The model also simulated the dynamics of continuous BMI evolution, glycemic status change during pregnancy and diabetes classification driven by the individual-level physiological model. We further modeled public health service pathways providing diagnosis and care for DIP to explore the optimization of resource use during service delivery. The model was extensively calibrated against empirical data.Comment: 10 pages, SBP-BRiMS 201

A survey of agent-oriented methodologies

This article introduces the current agent-oriented methodologies. It discusses what approaches have been followed (mainly extending existing object oriented and knowledge engineering methodologies), the suitability of these approaches for agent modelling, and some conclusions drawn from the survey

Design-time formal verification for smart environments: an exploratory perspective

Smart environments (SmE) are richly integrated with multiple heterogeneous devices; they perform the operations in intelligent manner by considering the context and actions/behaviors of the users. Their major objective is to enable the environment to provide ease and comfort to the users. The reliance on these systems demands consistent behavior. The versatility of devices, user behavior and intricacy of communication complicate the modeling and verification of SmE's reliable behavior. Of the many available modeling and verification techniques, formal methods appear to be the most promising. Due to a large variety of implementation scenarios and support for conditional behavior/processing, the concept of SmE is applicable to diverse areas which calls for focused research. As a result, a number of modeling and verification techniques have been made available for designers. This paper explores and puts into perspective the modeling and verification techniques based on an extended literature survey. These techniques mainly focus on some specific aspects, with a few overlapping scenarios (such as user interaction, devices interaction and control, context awareness, etc.), which were of the interest to the researchers based on their specialized competencies. The techniques are categorized on the basis of various factors and formalisms considered for the modeling and verification and later analyzed. The results show that no surveyed technique maintains a holistic perspective; each technique is used for the modeling and verification of specific SmE aspects. The results further help the designers select appropriate modeling and verification techniques under given requirements and stress for more R&D effort into SmE modeling and verification researc

Collaborative Verification-Driven Engineering of Hybrid Systems

Hybrid systems with both discrete and continuous dynamics are an important model for real-world cyber-physical systems. The key challenge is to ensure their correct functioning w.r.t. safety requirements. Promising techniques to ensure safety seem to be model-driven engineering to develop hybrid systems in a well-defined and traceable manner, and formal verification to prove their correctness. Their combination forms the vision of verification-driven engineering. Often, hybrid systems are rather complex in that they require expertise from many domains (e.g., robotics, control systems, computer science, software engineering, and mechanical engineering). Moreover, despite the remarkable progress in automating formal verification of hybrid systems, the construction of proofs of complex systems often requires nontrivial human guidance, since hybrid systems verification tools solve undecidable problems. It is, thus, not uncommon for development and verification teams to consist of many players with diverse expertise. This paper introduces a verification-driven engineering toolset that extends our previous work on hybrid and arithmetic verification with tools for (i) graphical (UML) and textual modeling of hybrid systems, (ii) exchanging and comparing models and proofs, and (iii) managing verification tasks. This toolset makes it easier to tackle large-scale verification tasks

Prototype of Fault Adaptive Embedded Software for Large-Scale Real-Time Systems

This paper describes a comprehensive prototype of large-scale fault adaptive embedded software developed for the proposed Fermilab BTeV high energy physics experiment. Lightweight self-optimizing agents embedded within Level 1 of the prototype are responsible for proactive and reactive monitoring and mitigation based on specified layers of competence. The agents are self-protecting, detecting cascading failures using a distributed approach. Adaptive, reconfigurable, and mobile objects for reliablility are designed to be self-configuring to adapt automatically to dynamically changing environments. These objects provide a self-healing layer with the ability to discover, diagnose, and react to discontinuities in real-time processing. A generic modeling environment was developed to facilitate design and implementation of hardware resource specifications, application data flow, and failure mitigation strategies. Level 1 of the planned BTeV trigger system alone will consist of 2500 DSPs, so the number of components and intractable fault scenarios involved make it impossible to design an `expert system' that applies traditional centralized mitigative strategies based on rules capturing every possible system state. Instead, a distributed reactive approach is implemented using the tools and methodologies developed by the Real-Time Embedded Systems group.Comment: 2nd Workshop on Engineering of Autonomic Systems (EASe), in the 12th Annual IEEE International Conference and Workshop on the Engineering of Computer Based Systems (ECBS), Washington, DC, April, 200

DoMAIns: Domain-based Modeling for Ambient Intelligence

Ambient Intelligence and Smart Home Automation systems are currently emerging as feasible and ready to exploit solutions to support more intelligent features inside future and current homes. Thanks to increased availability of off-the-shelf components and to relatively easy to implement solutions we are experiencing a steady evolution of households, causing an ever-increasing users’ awareness of the capabilities of such innovative environments. To foster effective adoption of Smart Home Automation technologies in our home environments, traditional architectural and plant design must be complemented by sound design methodologies and tools, supporting the whole environment design cycle, including for example modeling, simulation and emulation, as well as, when feasible, formal model-checking and verification. Several research efforts have already addressed the design of expressive modeling tools, mostly based on Semantic Web technologies, as well as of suitable platforms for adding interoperation and rule-based intelligence to home environments. This paper proposes a new modeling methodology designed to fit the different phases of Intelligent Environments design, with a particular focus on validation and verification of the whole system. Carefully designed separation of modeled entities permits to exploit the DoMAIns framework during all phases of the environment design, from early abstract conception to the final in-field deployment. The DoMAIns design methodology is applied to a sample use case that involves comprehensive modeling and simulation of a Bank Security Booth, including the environment, the control algorithms, the automation devices and the user. Results show that the approach is feasible and that can easily handle different types of environment modeling, required in the different design phases, and for each of them it may support simulation, emulation, or other verification techniques

A test case generation framework based on UML statechart diagram

Early software fault detection offers more flexibility to correct errors in the early development stages. Unfortunately, existing studies in this domain are not sufficiently comprehensive in describing the major processes of the automated test case generation. Furthermore, the algorithms used for test case generation are not provided or well described. Current studies also hardly address loops and parallel paths issues, and achieved low coverage criteria. Therefore, this study proposes a test case generation framework that generates minimized and prioritized test cases from UML statechart diagram with higher coverage criteria. This study, conducted a review of the previous research to identify the issues and gaps related to test case generation, model-based testing, and coverage criteria. The proposed framework was designed from the gathered information based on the reviews and consists of eight components that represent a comprehensive test case generation processes. They are relation table, relation graph, consistency checking, test path minimization, test path prioritization, path pruning, test path generation, and test case generation. In addition, a prototype to implement the framework was developed. The evaluation of the framework was conducted in three phases: prototyping, comparison with previous studies, and expert review. The results reveal that the most suitable coverage criteria for UML statechart diagram are all-states coverage, all-transitions coverage, alltransition-pairs coverage, and all-loop-free-paths coverage. Furthermore, this study achieves higher coverage criteria in all coverage criteria, except for all-state coverage, when compared with the previous studies. The results of the experts’ review show that the framework is practical, easy to implement due to it is suitability to generate the test cases. The proposed algorithms provide correct results, and the prototype is able to generate test case effectively. Generally, the proposed system is well accepted by experts owing to its usefulness, usability, and accuracy. This study contributes to both theory and practice by providing an early alternative test case generation framework that achieves high coverage and can effectively generate test cases from UML statechart diagrams. This research adds new knowledge to the software testing field, especially for testing processes in the model-based techniques, testing activity, and testing tool support