Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia

Cognitive function is an important end point of treatments in dementia clinical trials. Measuring cognitive function by standardized tests, however, is biased toward highly constrained environments (such as hospitals) in selected samples. Patient-powered real-world evidence using information and communication technology devices, including environmental and wearable sensors, may help to overcome these limitations. This position paper describes current and novel information and communication technology devices and algorithms to monitor behavior and function in people with prodromal and manifest stages of dementia continuously, and discusses clinical, technological, ethical, regulatory, and user-centered requirements for collecting real-world evidence in future randomized controlled trials. Challenges of data safety, quality, and privacy and regulatory requirements need to be addressed by future smart sensor technologies. When these requirements are satisfied, these technologies will provide access to truly user relevant outcomes and broader cohorts of participants than currently sampled in clinical trials

Context-aware gestural interaction in the smart environments of the ubiquitous computing era

A thesis submitted to the University of Bedfordshire in partial fulfilment of the requirements for the degree of Doctor of PhilosophyTechnology is becoming pervasive and the current interfaces are not adequate for the interaction with the smart environments of the ubiquitous computing era. Recently, researchers have started to address this issue introducing the concept of natural user interface, which is mainly based on gestural interactions. Many issues are still open in this emerging domain and, in particular, there is a lack of common guidelines for coherent implementation of gestural interfaces. This research investigates gestural interactions between humans and smart environments. It proposes a novel framework for the high-level organization of the context information. The framework is conceived to provide the support for a novel approach using functional gestures to reduce the gesture ambiguity and the number of gestures in taxonomies and improve the usability. In order to validate this framework, a proof-of-concept has been developed. A prototype has been developed by implementing a novel method for the view-invariant recognition of deictic and dynamic gestures. Tests have been conducted to assess the gesture recognition accuracy and the usability of the interfaces developed following the proposed framework. The results show that the method provides optimal gesture recognition from very different view-points whilst the usability tests have yielded high scores. Further investigation on the context information has been performed tackling the problem of user status. It is intended as human activity and a technique based on an innovative application of electromyography is proposed. The tests show that the proposed technique has achieved good activity recognition accuracy. The context is treated also as system status. In ubiquitous computing, the system can adopt different paradigms: wearable, environmental and pervasive. A novel paradigm, called synergistic paradigm, is presented combining the advantages of the wearable and environmental paradigms. Moreover, it augments the interaction possibilities of the user and ensures better gesture recognition accuracy than with the other paradigms

A planetary nervous system for social mining and collective awareness

We present a research roadmap of a Planetary Nervous System (PNS), capable of sensing and mining the digital breadcrumbs of human activities and unveiling the knowledge hidden in the big data for addressing the big questions about social complexity. We envision the PNS as a globally distributed, self-organizing, techno-social system for answering analytical questions about the status of world-wide society, based on three pillars: social sensing, social mining and the idea of trust networks and privacy-aware social mining. We discuss the ingredients of a science and a technology necessary to build the PNS upon the three mentioned pillars, beyond the limitations of their respective state-of-art. Social sensing is aimed at developing better methods for harvesting the big data from the techno-social ecosystem and make them available for mining, learning and analysis at a properly high abstraction level. Social mining is the problem of discovering patterns and models of human behaviour from the sensed data across the various social dimensions by data mining, machine learning and social network analysis. Trusted networks and privacy-aware social mining is aimed at creating a new deal around the questions of privacy and data ownership empowering individual persons with full awareness and control on own personal data, so that users may allow access and use of their data for their own good and the common good. The PNS will provide a goal-oriented knowledge discovery framework, made of technology and people, able to configure itself to the aim of answering questions about the pulse of global society. Given an analytical request, the PNS activates a process composed by a variety of interconnected tasks exploiting the social sensing and mining methods within the transparent ecosystem provided by the trusted network. The PNS we foresee is the key tool for individual and collective awareness for the knowledge society. We need such a tool for everyone to become fully aware of how powerful is the knowledge of our society we can achieve by leveraging our wisdom as a crowd, and how important is that everybody participates both as a consumer and as a producer of the social knowledge, for it to become a trustable, accessible, safe and useful public good.Seventh Framework Programme (European Commission) (grant agreement No. 284709

An Argumentation-based Perspective over the Social IoT

The crucial role played by social interactions between smart objects in the Internet of Things is being rapidly recognized by the Social Internet of Things (SIoT) vision. In this paper, we build upon the recently introduced vision of Speaking Objects – “things” interacting through argumentation – to show how different forms of human dialogue naturally fit cooperation and coordination requirements of the SIoT. In particular, we show how speaking objects can exchange arguments in order to seek for information, negotiate over an issue, persuade others, deliberate actions, and so on, namely, striving to reach consensus about the state of affairs and their goals. In this context, we illustrate how argumentation naturally enables such a form of conversational coordination through practical examples and a case study scenario

A planetary nervous system for social mining and collective awareness

We present a research roadmap of a Planetary Nervous System (PNS), capable of sensing and mining the digital breadcrumbs of human activities and unveiling the knowledge hidden in the big data for addressing the big questions about social complexity. We envision the PNS as a globally distributed, self-organizing, techno-social system for answering analytical questions about the status of world-wide society, based on three pillars: social sensing, social mining and the idea of trust networks and privacy-aware social mining. We discuss the ingredients of a science and a technology necessary to build the PNS upon the three mentioned pillars, beyond the limitations of their respective state-of-art. Social sensing is aimed at developing better methods for harvesting the big data from the techno-social ecosystem and make them available for mining, learning and analysis at a properly high abstraction level. Social mining is the problem of discovering patterns and models of human behaviour from the sensed data across the various social dimensions by data mining, machine learning and social network analysis. Trusted networks and privacy-aware social mining is aimed at creating a new deal around the questions of privacy and data ownership empowering individual persons with full awareness and control on own personal data, so that users may allow access and use of their data for their own good and the common good. The PNS will provide a goal-oriented knowledge discovery framework, made of technology and people, able to configure itself to the aim of answering questions about the pulse of global society. Given an analytical request, the PNS activates a process composed by a variety of interconnected tasks exploiting the social sensing and mining methods within the transparent ecosystem provided by the trusted network. The PNS we foresee is the key tool for individual and collective awareness for the knowledge society. We need such a tool for everyone to become fully aware of how powerful is the knowledge of our society we can achieve by leveraging our wisdom as a crowd, and how important is that everybody participates both as a consumer and as a producer of the social knowledge, for it to become a trustable, accessible, safe and useful public good. Graphical abstrac