Wavelet feature extraction and genetic algorithm for biomarker detection in colorectal cancer data

Biomarkers which predict patient’s survival can play an important role in medical diagnosis and treatment. How to select the significant biomarkers from hundreds of protein markers is a key step in survival analysis. In this paper a novel method is proposed to detect the prognostic biomarkers ofsurvival in colorectal cancer patients using wavelet analysis, genetic algorithm, and Bayes classifier. One dimensional discrete wavelet transform (DWT) is normally used to reduce the dimensionality of biomedical data. In this study one dimensional continuous wavelet transform (CWT) was proposed to extract the features of colorectal cancer data. One dimensional CWT has no ability to reduce dimensionality of data, but captures the missing features of DWT, and is complementary part of DWT. Genetic algorithm was performed on extracted wavelet coefficients to select the optimized features, using Bayes classifier to build its fitness function. The corresponding protein markers were located based on the position of optimized features. Kaplan-Meier curve and Cox regression model 2 were used to evaluate the performance of selected biomarkers. Experiments were conducted on colorectal cancer dataset and several significant biomarkers were detected. A new protein biomarker CD46 was found to significantly associate with survival time

A Fault Diagnosis Method for Power Transmission Networks Based on Spiking Neural P Systems with Self-Updating Rules considering Biological Apoptosis Mechanism

Power transmission networks play an important role in smart girds. Fast and accurate faulty-equipment identification is critical for fault diagnosis of power systems; however, it is rather difficult due to uncertain and incomplete fault alarm messages in fault events. This paper proposes a new fault diagnosis method of transmission networks in the framework of membrane computing. We first propose a class of spiking neural P systems with self-updating rules (srSNPS) considering biological apoptosis mechanism and its self-updating matrix reasoning algorithm. The srSNPS, for the first time, effectively unitizes the attribute reduction ability of rough sets and the apoptosis mechanism of biological neurons in a P system, where the apoptosis algorithm for condition neurons is devised to delete redundant information in fault messages. This simplifies the complexity of the srSNPS model and allows us to deal with the uncertainty and incompleteness of fault information in an objective way without using historical statistics and expertise. Then, the srSNPS-based fault diagnosis method is proposed. It is composed of the transmission network partition, the SNPS model establishment, the pulse value correction and computing, and the protection device behavior evaluation, where the first two components can be finished before failures to save diagnosis time. Finally, case studies based on the IEEE 14- and IEEE 118-bus systems verify the effectiveness and superiority of the proposed method

Analysis of cross-correlations in electroencephalogram signals as an approach to proactive diagnosis of schizophrenia

We apply flicker-noise spectroscopy (FNS), a time series analysis method operating on structure functions and power spectrum estimates, to study the clinical electroencephalogram (EEG) signals recorded in children/adolescents (11 to 14 years of age) with diagnosed schizophrenia-spectrum symptoms at the National Center for Psychiatric Health (NCPH) of the Russian Academy of Medical Sciences. The EEG signals for these subjects were compared with the signals for a control sample of chronically depressed children/adolescents. The purpose of the study is to look for diagnostic signs of subjects' susceptibility to schizophrenia in the FNS parameters for specific electrodes and cross-correlations between the signals simultaneously measured at different points on the scalp. Our analysis of EEG signals from scalp-mounted electrodes at locations F3 and F4, which are symmetrically positioned in the left and right frontal areas of cerebral cortex, respectively, demonstrates an essential role of frequency-phase synchronization, a phenomenon representing specific correlations between the characteristic frequencies and phases of excitations in the brain. We introduce quantitative measures of frequency-phase synchronization and systematize the values of FNS parameters for the EEG data. The comparison of our results with the medical diagnoses for 84 subjects performed at NCPH makes it possible to group the EEG signals into 4 categories corresponding to different risk levels of subjects' susceptibility to schizophrenia. We suggest that the introduced quantitative characteristics and classification of cross-correlations may be used for the diagnosis of schizophrenia at the early stages of its development.Comment: 36 pages, 6 figures, 2 tables; to be published in "Physica A

CBR and MBR techniques: review for an application in the emergencies domain

The purpose of this document is to provide an in-depth analysis of current reasoning engine practice and the integration strategies of Case Based Reasoning and Model Based Reasoning that will be used in the design and development of the RIMSAT system. RIMSAT (Remote Intelligent Management Support and Training) is a European Commission funded project designed to: a.. Provide an innovative, 'intelligent', knowledge based solution aimed at improving the quality of critical decisions b.. Enhance the competencies and responsiveness of individuals and organisations involved in highly complex, safety critical incidents - irrespective of their location. In other words, RIMSAT aims to design and implement a decision support system that using Case Base Reasoning as well as Model Base Reasoning technology is applied in the management of emergency situations. This document is part of a deliverable for RIMSAT project, and although it has been done in close contact with the requirements of the project, it provides an overview wide enough for providing a state of the art in integration strategies between CBR and MBR technologies.Postprint (published version

Fault Diagnosis System Based on Multiagent Technique for Ship Power System

Fault diagnosis system of ship power system can assist the crew to deal with faults, shorten the processing time, and prevent faults expanding. Multiagent technique is adopted for the fault diagnosis system. Ship power system is divided into several feeder units. Each one is abstracted as a regional feeder agent (FED-Agent). A multiagent fault diagnosis system is established with FED-Agent and other functional agents. Considering of the characteristics of agent, the multiagent system processes both autonomy and interactivity. It can solve fault diagnosis problem of ship power system effectively

Model based safety analysis for an Unmanned Aerial System

This paper aims at describing safety architectures of autonomous systems by using Event-B formal method. The autonomous systems combine various activities which can be organised in layers. The Event-B formalism well supports the rigorous design of this kind of systems. Its refinement mechanism allows a progressive modelling by checking the correctness and the relevance of the models by discharging proof obligations. The application of the Event-B method within the framework of layered architecture specification enables the emergence of desired global properties with relation to layer interactions. The safety objectives are derived in each layer and they involve static and dynamic properties such as an independence property, a redundant property or a sequential property. The originality of our approach is to consider a refinement process between two layers in which the abstract model is the model of the lower layer. In our modelling, we distinguish nominal behaviour and abnormal behaviour in order to well establish failure propagation in our architecture