Elastography: modality-specific approaches, clinical applications, and research horizons

Manual palpation has been used for centuries to provide a relative indication of tissue health and disease. Engineers have sought to make these assessments increasingly quantitative and accessible within daily clinical practice. Since many of the developed techniques involve image-based quantification of tissue deformation in response to an applied force (i.e., "elastography”), such approaches fall squarely within the domain of the radiologist. While commercial elastography analysis software is becoming increasingly available for clinical use, the internal workings of these packages often remain a "black box,” with limited guidance on how to usefully apply the methods toward a meaningful diagnosis. The purpose of the present review article is to introduce some important approaches to elastography that have been developed for the most widely used clinical imaging modalities (e.g., ultrasound, MRI), to provide a basic sense of the underlying physical principles, and to discuss both current and potential (musculoskeletal) applications. The article also seeks to provide a perspective on emerging approaches that are rapidly developing in the research laboratory (e.g., optical coherence tomography, fibered confocal microscopy), and which may eventually gain a clinical foothol

20 year evolution of Glyaderm® dermal regeneration matrix:the first non-commercial dermal regeneration matrix

The research of Dr. Pirayesh encompassed a series of carefully planned studies ranging from laboratory research to clinical applications. The goal was to develop and validate Glyaderm® as an effective dermal replacement. Long-term studies have shown that Glyaderm® can be effectively integrated with autologous skin grafting after wound bed preparation, resulting in reduced costs and morbidity.In a prospective, randomized clinical study, the effectiveness of Glyaderm® and autologous skin grafting was confirmed. This combination was found to be non-inferior to standard treatment in terms of graft uptake, scar scales and color. In addition, the two-stage procedure with Glyaderm® showed superior elasticity and better results in visual scar evaluation.Glyaderm® has proven to be an effective choice for burn treatment, with beneficial outcomes and a positive impact on patients' quality of life

Evaluation of bone-tendon junction healing using water jet ultrasound indentation method

2009-2010 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe