The Landscape of M-theory Compactifications on Seven-Manifolds with G2G_2 Holonomy

We study the physics of globally consistent four-dimensional $\mathcal{N}=1$ supersymmetric M-theory compactifications on $G_2$ manifolds constructed via twisted connected sum; there are now perhaps fifty million examples of these manifolds. We study a rich example that exhibits $U(1)^3$ gauge symmetry and a spectrum of massive charged particles that includes a trifundamental. Applying recent mathematical results to this example, we compute membrane instanton corrections to the superpotential and spacetime topology change in a compact model; the latter include both the (non-isolated) $G_2$ flop and conifold transitions. The conifold transition spontaneously breaks the gauge symmetry to $U(1)^2$, and associated field theoretic computations of particle charges make correct predictions for the topology of the deformed $G_2$ manifold. We discuss physical aspects of the abelian $G_2$ landscape broadly, including aspects of Higgs and Coulomb branches, membrane instanton corrections, and some general aspects of topology change.Comment: v1: 37 pages. v2: references added. v3: more discussion of instanton zero modes. JHEP version v4: references correcte

Anergy in self-directed B lymphocytes from a statistical mechanics perspective

The ability of the adaptive immune system to discriminate between self and non-self mainly stems from the ontogenic clonal-deletion of lymphocytes expressing strong binding affinity with self-peptides. However, some self-directed lymphocytes may evade selection and still be harmless due to a mechanism called clonal anergy. As for B lymphocytes, two major explanations for anergy developed over three decades: according to "Varela theory", it stems from a proper orchestration of the whole B-repertoire, in such a way that self-reactive clones, due to intensive interactions and feed-back from other clones, display more inertia to mount a response. On the other hand, according to the `two-signal model", which has prevailed nowadays, self-reacting cells are not stimulated by helper lymphocytes and the absence of such signaling yields anergy. The first result we present, achieved through disordered statistical mechanics, shows that helper cells do not prompt the activation and proliferation of a certain sub-group of B cells, which turn out to be just those broadly interacting, hence it merges the two approaches as a whole (in particular, Varela theory is then contained into the two-signal model). As a second result, we outline a minimal topological architecture for the B-world, where highly connected clones are self-directed as a natural consequence of an ontogenetic learning; this provides a mathematical framework to Varela perspective. As a consequence of these two achievements, clonal deletion and clonal anergy can be seen as two inter-playing aspects of the same phenomenon too

H-Spaces, Loop Spaces and the Space of Positive Scalar Curvature Metrics on the Sphere

For dimensions n greater than or equal to 3, we show that the space of metrics of positive scalar curvature on the n-sphere is homotopy equivalent to a subspace which takes the form of a H-space with a homotopy commutative, homotopy associative product operation. This product operation is based on the connected sum construction. We then exhibit an action of the little n-disks operad on this subspace which, using results of Boardman, Vogt and May implies that when n=3 or n is at least 5, the space of metrics of positive scalar curvature on the n-sphere is weakly homotopy equivalent to an n-fold loop space.Comment: 43 pages, 32 figures. In version 2 we added a line to the introduction acknowledging a relevant new result in the field. In version 3, we correct an error in the proof of the second main resul