262,183 research outputs found
Quality-aware model-driven service engineering
Service engineering and service-oriented architecture as an integration and platform technology is a recent approach to software systems integration. Quality aspects
ranging from interoperability to maintainability to performance are of central importance for the integration of heterogeneous, distributed service-based systems. Architecture models can substantially influence quality attributes of the implemented software systems. Besides the benefits of explicit architectures on maintainability and reuse, architectural constraints such as styles, reference architectures and architectural patterns can influence observable software properties such as performance. Empirical performance evaluation is a process of measuring and evaluating the performance of implemented software. We present an approach for addressing the quality of services and service-based systems at the model-level in the context of model-driven service engineering. The focus on architecture-level models is a consequence of the black-box
character of services
Multi-omics integration accurately predicts cellular state in unexplored conditions for Escherichia coli.
A significant obstacle in training predictive cell models is the lack of integrated data sources. We develop semi-supervised normalization pipelines and perform experimental characterization (growth, transcriptional, proteome) to create Ecomics, a consistent, quality-controlled multi-omics compendium for Escherichia coli with cohesive meta-data information. We then use this resource to train a multi-scale model that integrates four omics layers to predict genome-wide concentrations and growth dynamics. The genetic and environmental ontology reconstructed from the omics data is substantially different and complementary to the genetic and chemical ontologies. The integration of different layers confers an incremental increase in the prediction performance, as does the information about the known gene regulatory and protein-protein interactions. The predictive performance of the model ranges from 0.54 to 0.87 for the various omics layers, which far exceeds various baselines. This work provides an integrative framework of omics-driven predictive modelling that is broadly applicable to guide biological discovery
Recommended from our members
A linked data-driven & service-oriented architecture for sharing educational resources
The two fundamental aims of managing educational resources are to enable resources to be reusable and interoperable and to enable Web-scale sharing of resources across learning communities. Currently, a variety of approaches have been proposed to expose and manage educational resources and their metadata on the Web. These are usually based on heterogeneous metadata standards and schemas, such as IEEE LOM or ADL SCORM, and diverse repository interfaces such as OAI-PMH or SQI. Also, there is still a lack of usage of controlled vocabularies and available data sets that could replace the widespread use of unstructured text for describing resources. On the other hand, the Linked Data approach has proven that it offers a set of successful principles that have the potential to alleviate the aforementioned issues. In this paper, we introduce an architecture and prototype which is fundamentally based on (a) Linked Data principles and (b) Service-orientation to resolve the integration issues for sharing educational resources
Business Process Innovation using the Process Innovation Laboratory
Most organizations today are required not only to establish effective business processes but they are required to accommodate for changing business conditions at an increasing rate. Many business processes extend beyond the boundary of the enterprise into the supply chain and the information infrastructure therefore is critical. Today nearly every business relies on their Enterprise System (ES) for process integration and the future generations of enterprise systems will increasingly be driven by business process models. Consequently process modeling and improvement will become vital for business process innovation (BPI) in future organizations. There is a significant body of knowledge on various aspect of process innovation, e.g. on conceptual modeling, business processes, supply chains and enterprise systems. Still an overall comprehensive and consistent theoretical framework with guidelines for practical applications has not been identified. The aim of this paper is to establish a conceptual framework for business process innovation in the supply chain based on advanced enterprise systems. The main approach to business process innovation in this context is to create a new methodology for exploring process models and patterns of applications. The paper thus presents a new concept for business process innovation called the process innovation laboratory a.k.a. the Ă-Lab. The Ă-Lab is a comprehensive framework for BPI using advanced enterprise systems. The Ă-Lab is a collaborative workspace for experimenting with process models and an explorative approach to study integrated modeling in a controlled environment. The Ă-Lab facilitates innovation by using an integrated action learning approach to process modeling including contemporary technological, organizational and business perspectivesNo; keywords
Recommended from our members
A conceptual model of enterprise application integration in higher education institutions
Copyright @ 2013 EMCIS.It is eminent that several applicationsâ systems are deployed at different levels in Higher Education (HE), ranging from academic and administrative to staff and students record systems. Many of these systems suffer from different problems due to the lack of integration such as data redundancy, inconsistency and maintenance cost. Enterprise Application Integration (EAI) can provide substantial benefits to these systems, such as assisting with business process integration, facilitating e-service based transformation and supporting collaborative decision-making. However, some factors that influence EAI adoption process in HE will be defined. This paper introduces a conceptual model to explain the outcome of using EAI in Higher Education Institutions (HEIs). Analyzing the combination of the existing classification of EAI factors with the HE factors will enhance the implementation of EAI in HEI at both organizational and operational levels. A pilot study at King Abdulaziz University (KAU), Kingdom of Saudi Arabia will be presented in this paper to show that the integration of the multiple information systems gives an integrated view to facilitate information access and reuse. Moreover data from different information systems is combined to gain a more comprehensive basis to satisfy the educational needs
- âŚ