Evaluating performance of biomedical image retrieval systems - an overview of the medical image retrieval task at ImageCLEF 2004-2013

Medical image retrieval and classification have been extremely active research topics over the past 15 years. Within the ImageCLEF benchmark in medical image retrieval and classification, a standard test bed was created that allows researchers to compare their approaches and ideas on increasingly large and varied data sets including generated ground truth. This article describes the lessons learned in ten evaluation campaigns. A detailed analysis of the data also highlights the value of the resources created

Use Case Oriented Medical Visual Information Retrieval & System Evaluation

Large amounts of medical visual data are produced daily in hospitals, while new imaging techniques continue to emerge. In addition, many images are made available continuously via publications in the scientific literature and can also be valuable for clinical routine, research and education. Information retrieval systems are useful tools to provide access to the biomedical literature and fulfil the information needs of medical professionals. The tools developed in this thesis can potentially help clinicians make decisions about difficult diagnoses via a case-based retrieval system based on a use case associated with a specific evaluation task. This system retrieves articles from the biomedical literature when querying with a case description and attached images. This thesis proposes a multimodal approach for medical case-based retrieval with focus on the integration of visual information connected to text. Furthermore, the ImageCLEFmed evaluation campaign was organised during this thesis promoting medical retrieval system evaluation

Fusion Techniques in Biomedical Information Retrieval

For difficult cases clinicians usually use their experience and also the information found in textbooks to determine a diagnosis. Computer tools can help them supply the relevant information now that much medical knowledge is available in digital form. A biomedical search system such as developed in the Khresmoi project (that this chapter partially reuses) has the goal to fulfil information needs of physicians. This chapter concentrates on information needs for medical cases that contain a large variety of data, from free text, structured data to images. Fusion techniques will be compared to combine the various information sources to supply cases similar to an example case given. This can supply physicians with answers to problems similar to the one they are analyzing and can help in diagnosis and treatment planning

Overview of the ImageCLEF 2015 medical classification task

This articles describes the ImageCLEF 2015 Medical Clas-sification task. The task contains several subtasks that all use a dataset of figures from the biomedical open access literature (PubMed Cen-tral). Particularly compound figures are targeted that are frequent inthe literature. For more detailed information analysis and retrieval it isimportant to extract targeted information from the compound figures.The proposed tasks include compound figure detection (separating com-pound from other figures), multi–label classification (define all sub typespresent), figure separation (find boundaries of the subfigures) and modal-ity classification (detecting the figure type of each subfigure). The tasksare described with the participation of international research groups inthe tasks. The results of the participants are then described and analysedto identify promising techniques

Semi–Supervised Learning for Image Modality Classification

Searching for medical image content is a regular task for many physicians, especially in radiology. Retrieval of medical images from the scientific literature can benefit from automatic modality classification to focus the search and filter out non–relevant items. Training datasets are often unevenly distributed regarding the classes resulting sometimes in a less than optimal classification performance. This article proposes a semi–supervised learning approach applied using a k–Nearest Neighbour (k–NN) classifier to exploit unlabelled data and to expand the training set. The algorithmic implementation is described and the method is evaluated on the ImageCLEFmed modality classification benchmark. Results show that this approach achieves an improved performance over supervised k–NN and Random Forest classifiers. Moreover, medical case–based retrieval benefits from the modality filter

Data fusion techniques for biomedical informatics and clinical decision support

Data fusion can be used to combine multiple data sources or modalities to facilitate enhanced visualization, analysis, detection, estimation, or classification. Data fusion can be applied at the raw-data, feature-based, and decision-based levels. Data fusion applications of different sorts have been built up in areas such as statistics, computer vision and other machine learning aspects. It has been employed in a variety of realistic scenarios such as medical diagnosis, clinical decision support, and structural health monitoring. This dissertation includes investigation and development of methods to perform data fusion for cervical cancer intraepithelial neoplasia (CIN) and a clinical decision support system. The general framework for these applications includes image processing followed by feature development and classification of the detected region of interest (ROI). Image processing methods such as k-means clustering based on color information, dilation, erosion and centroid locating methods were used for ROI detection. The features extracted include texture, color, nuclei-based and triangle features. Analysis and classification was performed using feature- and decision-level data fusion techniques such as support vector machine, statistical methods such as logistic regression, linear discriminant analysis and voting algorithms --Abstract, page iv

Recuperação de informação multimodal em repositórios de imagem médica

The proliferation of digital medical imaging modalities in hospitals and other diagnostic facilities has created huge repositories of valuable data, often not fully explored. Moreover, the past few years show a growing trend of data production. As such, studying new ways to index, process and retrieve medical images becomes an important subject to be addressed by the wider community of radiologists, scientists and engineers. Content-based image retrieval, which encompasses various methods, can exploit the visual information of a medical imaging archive, and is known to be beneficial to practitioners and researchers. However, the integration of the latest systems for medical image retrieval into clinical workflows is still rare, and their effectiveness still show room for improvement. This thesis proposes solutions and methods for multimodal information retrieval, in the context of medical imaging repositories. The major contributions are a search engine for medical imaging studies supporting multimodal queries in an extensible archive; a framework for automated labeling of medical images for content discovery; and an assessment and proposal of feature learning techniques for concept detection from medical images, exhibiting greater potential than feature extraction algorithms that were pertinently used in similar tasks. These contributions, each in their own dimension, seek to narrow the scientific and technical gap towards the development and adoption of novel multimodal medical image retrieval systems, to ultimately become part of the workflows of medical practitioners, teachers, and researchers in healthcare.A proliferação de modalidades de imagem médica digital, em hospitais, clínicas e outros centros de diagnóstico, levou à criação de enormes repositórios de dados, frequentemente não explorados na sua totalidade. Além disso, os últimos anos revelam, claramente, uma tendência para o crescimento da produção de dados. Portanto, torna-se importante estudar novas maneiras de indexar, processar e recuperar imagens médicas, por parte da comunidade alargada de radiologistas, cientistas e engenheiros. A recuperação de imagens baseada em conteúdo, que envolve uma grande variedade de métodos, permite a exploração da informação visual num arquivo de imagem médica, o que traz benefícios para os médicos e investigadores. Contudo, a integração destas soluções nos fluxos de trabalho é ainda rara e a eficácia dos mais recentes sistemas de recuperação de imagem médica pode ser melhorada. A presente tese propõe soluções e métodos para recuperação de informação multimodal, no contexto de repositórios de imagem médica. As contribuições principais são as seguintes: um motor de pesquisa para estudos de imagem médica com suporte a pesquisas multimodais num arquivo extensível; uma estrutura para a anotação automática de imagens; e uma avaliação e proposta de técnicas de representation learning para deteção automática de conceitos em imagens médicas, exibindo maior potencial do que as técnicas de extração de features visuais outrora pertinentes em tarefas semelhantes. Estas contribuições procuram reduzir as dificuldades técnicas e científicas para o desenvolvimento e adoção de sistemas modernos de recuperação de imagem médica multimodal, de modo a que estes façam finalmente parte das ferramentas típicas dos profissionais, professores e investigadores da área da saúde.Programa Doutoral em Informátic