An efficient telemetry system for restoring sight

PhD ThesisThe human nervous system can be damaged as a result of disease or trauma, causing conditions such as Parkinson’s disease. Most people try pharmaceuticals as a primary method of treatment. However, drugs cannot restore some cases, such as visual disorder. Alternatively, this impairment can be treated with electronic neural prostheses. A retinal prosthesis is an example of that for restoring sight, but it is not efficient and only people with retinal pigmentosa benefit from it. In such treatments, stimulation of the nervous system can be achieved by electrical or optical means. In the latter case, the nerves need to be rendered light sensitive via genetic means (optogenetics). High radiance photonic devices are then required to deliver light to the target tissue. Such optical approaches hold the potential to be more effective while causing less harm to the brain tissue. As these devices are implanted in tissue, wireless means need to be used to communicate with them. For this, IEEE 802.15.6 or Bluetooth protocols at 2.4GHz are potentially compatible with most advanced electronic devices, and are also safe and secure. Also, wireless power delivery can operate the implanted device. In this thesis, a fully wireless and efficient visual cortical stimulator was designed to restore the sight of the blind. This system is likely to address 40% of the causes of blindness. In general, the system can be divided into two parts, hardware and software. Hardware parts include a wireless power transfer design, the communication device, power management, a processor and the control unit, and the 3D design for assembly. The software part contains the image simplification, image compression, data encoding, pulse modulation, and the control system. Real-time video streaming is processed and sent over Bluetooth, and data are received by the LPC4330 six layer implanted board. After retrieving the compressed data, the processed data are again sent to the implanted electrode/optrode to stimulate the brain’s nerve cells

Biomedical Engineering

Biomedical engineering is currently relatively wide scientific area which has been constantly bringing innovations with an objective to support and improve all areas of medicine such as therapy, diagnostics and rehabilitation. It holds a strong position also in natural and biological sciences. In the terms of application, biomedical engineering is present at almost all technical universities where some of them are targeted for the research and development in this area. The presented book brings chosen outputs and results of research and development tasks, often supported by important world or European framework programs or grant agencies. The knowledge and findings from the area of biomaterials, bioelectronics, bioinformatics, biomedical devices and tools or computer support in the processes of diagnostics and therapy are defined in a way that they bring both basic information to a reader and also specific outputs with a possible further use in research and development

Ultra-thin and flexible CMOS technology: ISFET-based microsystem for biomedical applications

A new paradigm of silicon technology is the ultra-thin chip (UTC) technology and the emerging applications. Very thin integrated circuits (ICs) with through-silicon vias (TSVs) will allow the stacking and interconnection of multiple dies in a compact format allowing a migration towards three-dimensional ICs (3D-ICs). Also, extremely thin and therefore mechanically bendable silicon chips in conjunction with the emerging thin-film and organic semiconductor technologies will enhance the performance and functionality of large-area flexible electronic systems. However, UTC technology requires special attention related to the circuit design, fabrication, dicing and handling of ultra-thin chips as they have different physical properties compared to their bulky counterparts. Also, transistors and other active devices on UTCs experiencing variable bending stresses will suffer from the piezoresistive effect of silicon substrate which results in a shift of their operating point and therefore, an additional aspect should be considered during circuit design. This thesis tries to address some of these challenges related to UTC technology by focusing initially on modelling of transistors on mechanically bendable Si-UTCs. The developed behavioural models are a combination of mathematical equations and extracted parameters from BSIM4 and BSIM6 modified by a set of equations describing the bending-induced stresses on silicon. The transistor models are written in Verilog-A and compiled in Cadence Virtuoso environment where they were simulated at different bending conditions. To complement this, the verification of these models through experimental results is also presented. Two chips were designed using a 180 nm CMOS technology. The first chip includes nMOS and pMOS transistors with fixed channel width and two different channel lengths and two different channel orientations (0° and 90°) with respect to the wafer crystal orientation. The second chip includes inverter logic gates with different transistor sizes and orientations, as in the previous chip. Both chips were thinned down to ∼20m using dicing-before-grinding (DBG) prior to electrical characterisation at different bending conditions. Furthermore, this thesis presents the first reported fully integrated CMOS-based ISFET microsystem on UTC technology. The design of the integrated CMOS-based ISFET chip with 512 integrated on-chip ISFET sensors along with their read-out and digitisation scheme is presented. The integrated circuits (ICs) are thinned down to ∼30m and the bulky, as well as thinned ICs, are electrically and electrochemically characterised. Also, the thesis presents the first reported mechanically bendable CMOS-based ISFET device demonstrating that mechanical deformation of the die can result in drift compensation through the exploitation of the piezoresistive nature of silicon. Finally, this thesis presents the studies towards the development of on-chip reference electrodes and biodegradable and ultra-thin biosensors for the detection of neurotransmitters such as dopamine and serotonin

Battery-less near field communications (nfc) sensors for internet of things (iot) applications

L’ implementació de la tecnologia de comunicació de camp proper (NFC) en els telèfons intel·ligents no para de créixer degut a l’ús d’aquesta per fer pagaments, això, junt amb el fet de poder aprofitar l’energia generada pel mòbil no només per la comunicació, sinó també per transmetre energia, el baix cost dels xips NFC, i el fet de que els telèfons tinguin connectivitat amb internet, possibilita i fa molt interesant el disseny d’etiquetes sense bateria incorporant-hi sensors i poder enviar la informació al núvol, dins del creixent escenari de l’internet de les coses (IoT). La present Tesi estudia la viabilitat d’aquests sensors, analitzant la màxima distància entre lector i sensor per proveir la potència necessària, presenta tècniques per augmentar el rang d’operació, i analitza els efectes de certs materials quan aquests estan propers a les antenes. Diversos sensors han estat dissenyats i analitzats i son presentats en aquest treball. Aquests son: Una etiqueta que mesura la humitat de la terra, la temperatura i la humitat relativa de l’aire per controlar les condicions de plantes. Un sensor per detectar la humitat en bolquers, imprès en material flexible que s’adapta a la forma del bolquer. Dues aplicacions, una per estimació de pH i una altre per avaluar el grau de maduració de fruites, basats en un sensor de color. I, per últim, s’estudia la viabilitat de sensors en implants per aplicacions mèdiques, analitzant l’efecte del cos i proposant un sistema per augmentar la profunditat a la que aquests es poden llegir utilitzant un telèfon mòbil. Tots aquests sensors poden ser alimentats i llegits per qualsevol dispositiu que disposin de connexió NFC.La implementación de la tecnología de comunicaciones de campo cercano (NFC) en los teléfonos inteligentes no para de crecer debido al uso de esta para llevar a cabo pagos, esto, junto con el hecho de poder aprovechar la energía generada por el móvil no sólo para la comunicación, sino también para transmitir energía, el bajo coste de los chips NFC, i el hecho que los teléfonos tengan conectividad a internet, posibilita y hace muy interesante el diseño de etiquetas sin batería que incorporen sensores i poder enviar la información a la nube, enmarcado en el creciente escenario del internet de las cosas (IoT). La presente Tesis estudia la viabilidad de estos sensores, analizando la máxima distancia entre lector i sensor para proveer la potencia necesaria, presenta técnicas para aumentar el rango de operación, y analiza los efectos de ciertos materiales cuando estos están cerca de las antenas. Varios sensores han sido diseñados y analizados y son presentados en este trabajo. Estos son: Una etiqueta que mide la humedad de la tierra, la temperatura y la humedad relativa del aire para controlar las condiciones de plantas. Un sensor para detectar la humedad en pañales, impreso en material flexible que se adapta a la forma del pañal. Dos aplicaciones, una para estimación de pH y otra para evaluar el grado de maduración de frutas, basados en un sensor de color. Y, por último, se estudia la viabilidad de sensores en implantes para aplicaciones médicas, analizando el efecto del cuerpo y proponiendo un sistema para aumentar la profundidad a la que estos se pueden leer usando un teléfono móvil. Todos estos sensores pueden ser alimentados y leídos por cualquier dispositivo que disponga de conexión NFC.The implementation of near field communication (NFC) technology into smartphones grows rapidly due the use of this technology as a payment system. This, altogether with the fact that the energy generated by the phone can be used not only to communicate but for power transfer as well, the low-cost of the NFC chips, and the fact that the smartphones have connectivity to internet, makes possible and very interesting the design of battery-less sensing tags which information can be sent to the cloud, within the growing internet of things (IoT) scenario. This Thesis studies the feasibility of these sensors, analysing the maximum distance between reader and sensor to provide the necessary power, presents techniques to increase the range of operation, and analyses the effects of certain materials when they are near to the antennas. Several sensors have been designed and analysed and are presented in this work. These are: a tag that measures the soil moisture, the temperature and the relative humidity of the air to control the conditions of plants. A moisture sensor for diapers, printed on flexible material that adapts to the diaper shape. Two applications, one for pH estimation and another for assessing the degree of fruit ripening, based on a colour sensor. And finally, the feasibility of sensors in implants for medical applications is studied, analysing the effect of the body and proposing a system to increase the depth at which they can be read using a mobile phone. All of these sensors can be powered and read by any NFC enabled device