Mixed Cumulative Distribution Networks

Directed acyclic graphs (DAGs) are a popular framework to express multivariate probability distributions. Acyclic directed mixed graphs (ADMGs) are generalizations of DAGs that can succinctly capture much richer sets of conditional independencies, and are especially useful in modeling the effects of latent variables implicitly. Unfortunately there are currently no good parameterizations of general ADMGs. In this paper, we apply recent work on cumulative distribution networks and copulas to propose one one general construction for ADMG models. We consider a simple parameter estimation approach, and report some encouraging experimental results.Comment: 11 pages, 4 figure

Grouping complex systems: a weighted network comparative analysis

In this study, the authors compare two inter-municipal commuting networks (MCN) pertaining to the Italian islands of Sardinia and Sicily, by approaching their characterization through a weighted network analysis. They develop on the results obtained for the MCN of Sardinia (De Montis et al. 2007) and attempt to use network analysis as a mean of detection of similarities or dissimilarities between the systems at hand

Molecular motors robustly drive active gels to a critically connected state

Living systems often exhibit internal driving: active, molecular processes drive nonequilibrium phenomena such as metabolism or migration. Active gels constitute a fascinating class of internally driven matter, where molecular motors exert localized stresses inside polymer networks. There is evidence that network crosslinking is required to allow motors to induce macroscopic contraction. Yet a quantitative understanding of how network connectivity enables contraction is lacking. Here we show experimentally that myosin motors contract crosslinked actin polymer networks to clusters with a scale-free size distribution. This critical behavior occurs over an unexpectedly broad range of crosslink concentrations. To understand this robustness, we develop a quantitative model of contractile networks that takes into account network restructuring: motors reduce connectivity by forcing crosslinks to unbind. Paradoxically, to coordinate global contractions, motor activity should be low. Otherwise, motors drive initially well-connected networks to a critical state where ruptures form across the entire network.Comment: Main text: 21 pages, 5 figures. Supplementary Information: 13 pages, 8 figure

MISEP - Linear and Nonlinear ICA Based on Mutual Information

MISEP is a method for linear and nonlinear ICA, that is able to handle a large variety of situations. It is an extension of the well known INFOMAX method, in two directions: (1) handling of nonlinear mixtures, and (2) learning the nonlinearities to be used at the outputs. The method can therefore separate linear and nonlinear mixtures of components with a wide range of statistical distributions. This paper presents the basis of the MISEP method, as well as experimental results obtained with it. The results illustrate the applicability of the method to various situations, and show that, although the nonlinear blind separation problem is ill-posed, use of regularization allows the problem to be solved when the nonlinear mixture is relatively smooth