97,458 research outputs found

    Laser Based Mid-Infrared Spectroscopic Imaging – Exploring a Novel Method for Application in Cancer Diagnosis

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    A number of biomedical studies have shown that mid-infrared spectroscopic images can provide both morphological and biochemical information that can be used for the diagnosis of cancer. Whilst this technique has shown great potential it has yet to be employed by the medical profession. By replacing the conventional broadband thermal source employed in modern FTIR spectrometers with high-brightness, broadly tuneable laser based sources (QCLs and OPGs) we aim to solve one of the main obstacles to the transfer of this technology to the medical arena; namely poor signal to noise ratios at high spatial resolutions and short image acquisition times. In this thesis we take the first steps towards developing the optimum experimental configuration, the data processing algorithms and the spectroscopic image contrast and enhancement methods needed to utilise these high intensity laser based sources. We show that a QCL system is better suited to providing numerical absorbance values (biochemical information) than an OPG system primarily due to the QCL pulse stability. We also discuss practical protocols for the application of spectroscopic imaging to cancer diagnosis and present our spectroscopic imaging results from our laser based spectroscopic imaging experiments of oesophageal cancer tissue

    ICLabel: An automated electroencephalographic independent component classifier, dataset, and website

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    The electroencephalogram (EEG) provides a non-invasive, minimally restrictive, and relatively low cost measure of mesoscale brain dynamics with high temporal resolution. Although signals recorded in parallel by multiple, near-adjacent EEG scalp electrode channels are highly-correlated and combine signals from many different sources, biological and non-biological, independent component analysis (ICA) has been shown to isolate the various source generator processes underlying those recordings. Independent components (IC) found by ICA decomposition can be manually inspected, selected, and interpreted, but doing so requires both time and practice as ICs have no particular order or intrinsic interpretations and therefore require further study of their properties. Alternatively, sufficiently-accurate automated IC classifiers can be used to classify ICs into broad source categories, speeding the analysis of EEG studies with many subjects and enabling the use of ICA decomposition in near-real-time applications. While many such classifiers have been proposed recently, this work presents the ICLabel project comprised of (1) an IC dataset containing spatiotemporal measures for over 200,000 ICs from more than 6,000 EEG recordings, (2) a website for collecting crowdsourced IC labels and educating EEG researchers and practitioners about IC interpretation, and (3) the automated ICLabel classifier. The classifier improves upon existing methods in two ways: by improving the accuracy of the computed label estimates and by enhancing its computational efficiency. The ICLabel classifier outperforms or performs comparably to the previous best publicly available method for all measured IC categories while computing those labels ten times faster than that classifier as shown in a rigorous comparison against all other publicly available EEG IC classifiers.Comment: Intended for NeuroImage. Updated from version one with minor editorial and figure change

    Automated Classification of Periodic Variable Stars detected by the Wide-field Infrared Survey Explorer

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    We describe a methodology to classify periodic variable stars identified using photometric time-series measurements constructed from the Wide-field Infrared Survey Explorer (WISE) full-mission single-exposure Source Databases. This will assist in the future construction of a WISE Variable Source Database that assigns variables to specific science classes as constrained by the WISE observing cadence with statistically meaningful classification probabilities. We have analyzed the WISE light curves of 8273 variable stars identified in previous optical variability surveys (MACHO, GCVS, and ASAS) and show that Fourier decomposition techniques can be extended into the mid-IR to assist with their classification. Combined with other periodic light-curve features, this sample is then used to train a machine-learned classifier based on the random forest (RF) method. Consistent with previous classification studies of variable stars in general, the RF machine-learned classifier is superior to other methods in terms of accuracy, robustness against outliers, and relative immunity to features that carry little or redundant class information. For the three most common classes identified by WISE: Algols, RR Lyrae, and W Ursae Majoris type variables, we obtain classification efficiencies of 80.7%, 82.7%, and 84.5% respectively using cross-validation analyses, with 95% confidence intervals of approximately +/-2%. These accuracies are achieved at purity (or reliability) levels of 88.5%, 96.2%, and 87.8% respectively, similar to that achieved in previous automated classification studies of periodic variable stars.Comment: 48 pages, 17 figures, 1 table, accepted by A

    Six Noise Type Military Sound Classifier

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    Blast noise from military installations often has a negative impact on the quality of life of residents living in nearby communities. This negatively impacts the military's testing \& training capabilities due to restrictions, curfews, or range closures enacted to address noise complaints. In order to more directly manage noise around military installations, accurate noise monitoring has become a necessity. Although most noise monitors are simple sound level meters, more recent ones are capable of discerning blasts from ambient noise with some success. Investigators at the University of Pittsburgh previously developed a more advanced noise classifier that can discern between wind, aircraft, and blast noise, while simultaneously lowering the measurement threshold. Recent work will be presented from the development of a more advanced classifier that identifies additional classes of noise such as machine gun fire, vehicles, and thunder. Additional signal metrics were explored given the increased complexity of the classifier. By broadening the types of noise the system can accurately classify and increasing the number of metrics, a new system was developed with increased blast noise accuracy, decreased number of missed events, and significantly fewer false positives

    Evaluation of SLAR and simulated thematic mapper MSS data for forest cover mapping using computer-aided analysis techniques

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    Kershaw County, South Carolina was selected as the study site for analyzing simulated thematic mapper MSS data and dual-polarized X-band synthetic aperture radar (SAR) data. The impact of the improved spatial and spectral characteristics of the LANDSAT D thematic mapper data on computer aided analysis for forest cover type mapping was examined as well as the value of synthetic aperture radar data for differentiating forest and other cover types. The utility of pattern recognition techniques for analyzing SAR data was assessed. Topics covered include: (1) collection and of TMS and reference data; (2) reformatting, geometric and radiometric rectification, and spatial resolution degradation of TMS data; (3) development of training statistics and test data sets; (4) evaluation of different numbers and combinations of wavelength bands on classification performance; (5) comparison among three classification algorithms; and (6) the effectiveness of the principal component transformation in data analysis. The collection, digitization, reformatting, and geometric adjustment of SAR data are also discussed. Image interpretation results and classification results are presented

    Classification software technique assessment

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    A catalog of software options is presented for the use of local user communities to obtain software for analyzing remotely sensed multispectral imagery. The resources required to utilize a particular software program are described. Descriptions of how a particular program analyzes data and the performance of that program for an application and data set provided by the user are shown. An effort is made to establish a statistical performance base for various software programs with regard to different data sets and analysis applications, to determine the status of the state-of-the-art

    EEF: Exponentially Embedded Families with Class-Specific Features for Classification

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    In this letter, we present a novel exponentially embedded families (EEF) based classification method, in which the probability density function (PDF) on raw data is estimated from the PDF on features. With the PDF construction, we show that class-specific features can be used in the proposed classification method, instead of a common feature subset for all classes as used in conventional approaches. We apply the proposed EEF classifier for text categorization as a case study and derive an optimal Bayesian classification rule with class-specific feature selection based on the Information Gain (IG) score. The promising performance on real-life data sets demonstrates the effectiveness of the proposed approach and indicates its wide potential applications.Comment: 9 pages, 3 figures, to be published in IEEE Signal Processing Letter. IEEE Signal Processing Letter, 201
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