Integral MRAC with Minimal Controller Synthesis and bounded adaptive gains: The continuous-time case

Model reference adaptive controllers designed via the Minimal Control Synthesis (MCS) approach are a viable solution to control plants affected by parameter uncertainty, unmodelled dynamics, and disturbances. Despite its effectiveness to impose the required reference dynamics, an apparent drift of the adaptive gains, which can eventually lead to closed-loop instability or alter tracking performance, may occasionally be induced by external disturbances. This problem has been recently addressed for this class of adaptive algorithms in the discrete-time case and for square-integrable perturbations by using a parameter projection strategy [1]. In this paper we tackle systematically this issue for MCS continuous-time adaptive systems with integral action by enhancing the adaptive mechanism not only with a parameter projection method, but also embedding a s-modification strategy. The former is used to preserve convergence to zero of the tracking error when the disturbance is bounded and L2, while the latter guarantees global uniform ultimate boundedness under continuous L8 disturbances. In both cases, the proposed control schemes ensure boundedness of all the closed-loop signals. The strategies are numerically validated by considering systems subject to different kinds of disturbances. In addition, an electrical power circuit is used to show the applicability of the algorithms to engineering problems requiring a precise tracking of a reference profile over a long time range despite disturbances, unmodelled dynamics, and parameter uncertainty.Postprint (author's final draft

Discrete-time integral MRAC with minimal controller synthesis and parameter projection

Model reference adaptive controllers with Minimal Control Synthesis are effective control algorithms to guarantee asymptotic convergence of the tracking error to zero not only for disturbance-free uncertain linear systems, but also for highly nonlinear plants with unknown parameters, unmodeled dynamics and subject to perturbations. However, an apparent drift in adaptive gains may occasionally arise, which can eventually lead to closed-loop instability. In this paper, we address this key issue for discrete-time systems under L-2 disturbances using a parameter projection algorithm. A consistent proof of stability of all the closed-loop signals is provided, while tracking error is shown to asymptotically converge to zero. We also show the applicability of the adaptive algorithm for digitally controlled continuous-time plants. The proposed algorithm is numerically validated taking into account a discrete-time LTI system subject to parameter uncertainty, parameter variations and L-2 disturbances. Finally, as a possible engineering application of this novel adaptive strategy, the control of a highly nonlinear electromechanical actuator is considered. (C) 2015 The Franldin Institute. Published by Elsevier Ltd. All rights reserved.Postprint (author's final draft

Design of a bistable switch to control cellular uptake

International audienceBistable switches are widely used in synthetic biology to trigger cellular functions in response to environmental signals. All bistable switches developed so far, however, control the expression of target genes without access to other layers of the cellular machinery. Here, we propose a bistable switch to control the rate at which cells take up a metabolite from the environment. An uptake switch provides a new interface to command metabolic activity from the extracellular space and has great potential as a building block in more complex circuits that coordinate pathway activity across cell cultures, allocate metabolic tasks among different strains or require cell-to-cell communication with metabolic signals. Inspired by uptake systems found in nature, we propose to couple metabolite import and utilization with a genetic circuit under feedback regulation. Using mathematical models and analysis, we determined the circuit architectures that produce bistability and obtained their design space for bistability in terms of experimentally tuneable parameters. We found an activation–repression architecture to be the most robust switch because it displays bistability for the largest range of design parameters and requires little fine-tuning of the promoters' response curves. Our analytic results are based on on–off approximations of promoter activity and are in excellent qualitative agreement with simulations of more realistic models. With further analysis and simulation, we established conditions to maximize the parameter design space and to produce bimodal phenotypes via hysteresis and cell-to-cell variability. Our results highlight how mathematical analysis can drive the discovery of new circuits for synthetic biology, as the proposed circuit has all the hallmarks of a toggle switch and stands as a promising design to control metabolic phenotypes across cell cultures

Direct data‐driven design of switching controllers

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