High-performance wireless interface for implant-to-air communications

Nous élaborons une interface cerveau-machine (ICM) entièrement sans fil afin de fournir un système de liaison directe entre le cerveau et les périphériques externes, permettant l’enregistrement et la stimulation du cerveau pour une utilisation permanente. Au cours de cette thèse, nous explorons la modélisation de canal, les antennes implantées et portables en tant que propagateurs appropriés pour cette application, la conception du nouveau système d’un émetteur-récepteur UWB implantable, la conception niveau système du circuit et sa mise en oeuvre par un procédé CMOS TSMC 0.18 um. En plus, en collaboration avec Université McGill, nous avons conçu un réseau de seize antennes pour une détection du cancer du sein à l’aide d’hyperfréquences. Notre première contribution calcule la caractérisation de canal de liaison sans fil UWB d’implant à l’air, l’absorption spécifique moyennée (ASAR), et les lignes directrices de la FCC sur la densité spectrale de puissance UWB transmis. La connaissance du comportement du canal est nécessaire pour déterminer la puissance maximale permise à 1) respecter les lignes directrices ANSI pour éviter des dommages aux tissus et 2) respecter les lignes directrices de la FCC sur les transmissions non autorisées. Nous avons recours à un modèle réaliste du canal biologique afin de concevoir les antennes pour l’émetteur implanté et le récepteur externe. Le placement des antennes est examiné avec deux scénarios contrastés ayant des contraintés de puissance. La performance du système au sein des tissus biologiques est examinée par l’intermédiaire des simulations et des expériences. Notre deuxième contribution est dédiée à la conception des antennes simples et à double polarisation pour les systèmes d’enregistrement neural sans fil à bande ultra-large en utilisant un modèle multicouches inhomogène de la tête humaine. Les antennes fabriquées à partir de matériaux flexibles sont plus facilement adaptées à l’implantation ; nous étudions des matériaux à la fois flexibles et rigides et examinons des compromis de performance. Les antennes proposées sont conçues pour fonctionner dans une plage de fréquence de 2-11 GHz (ayant S11-dessous de -10 dB) couvrant à la fois la bande 2.45 GHz (ISM) et la bande UWB 3.1-10.6 GHz. Des mesures confirment les résultats de simulation et montrent que les antennes flexibles ont peu de dégradation des performances en raison des effets de flexion (en termes de correspondance d’impédance). Finalement, une comparaison est réalisée entre quatre antennes implantables, couvrant la gamme 2-11 GHz : 1) une rigide, à la polarisation simple, 2) une rigide, à double polarisation, 3) une flexible, à simple polarisation et 4) une flexible, à double polarisation. Dans tous les cas une antenne rigide est utilisée à l’extérieur du corps, avec une polarisation appropriée. Plusieurs avantages ont été confirmés pour les antennes à la polarisation double : 1) une taille plus petite, 2) la sensibilité plus faible aux désalignements angulaires, et 3) une plus grande fidélité. Notre troisième contribution fournit la conception niveau système de l’architecture de communication sans fil pour les systèmes implantés qui stimulent simultanément les neurones et enregistrent les réponses de neurones. Cette architecture prend en charge un grand nombre d’électrodes (> 500), fournissant 100 Mb/s pour des signaux de stimulation de liaison descendante, et Gb/s pour les enregistrements de neurones de liaison montante. Nous proposons une architecture d’émetteur-récepteur qui partage une antenne ultra large bande, un émetteur-récepteur simplifié, travaillant en duplex intégral sur les deux bandes, et un nouveau formeur d’impulsions pour la liaison montante du Gb/s soutenant plusieurs formats de modulation. Nous présentons une démonstration expérimentale d’ex vivo de l’architecture en utilisant des composants discrets pour la réalisation les taux Gb/s en liaison montante. Une bonne performance de taux d’erreur de bit sur un canal biologique à 0,5, 1 et 2 Gb/s des débits de données pour la télémétrie de liaison montante (UWB) et 100 Mb/s pour la télémétrie en liaison descendante (bande 2.45 GHz) est atteinte. Notre quatrième contribution présente la conception au niveau du circuit d’un dispositif d’émission en duplex total qui est présentée dans notre troisième contribution. Ce dispositif d’émission en duplex total soutient les applications d’interfaçage neural multimodal et en haute densité (les canaux de stimulant et d’enregistrement) avec des débits de données asymétriques. L’émetteur (TX) et le récepteur (RX) partagent une seule antenne pour réduire la taille de l’implant. Le TX utilise impulse radio ultra-wide band (IR-UWB) basé sur une approche alliant des bords, et le RX utilise un nouveau 2.4 GHz récepteur on-off keying (OOK).Une bonne isolation (> 20 dB) entre le trajet TX et RX est mis en oeuvre 1) par mise en forme des impulsions transmises pour tomber dans le spectre UWB non réglementé (3.1-7 GHz), et 2) par un filtrage espace-efficace du spectre de liaison descendante OOK dans un amplificateur à faible bruit RX. L’émetteur UWB 3.1-7 GHz peut utiliser soit OOK soit la modulation numérique binaire à déplacement de phase (BPSK). Le FDT proposé offre une double bande avec un taux de données de liaison montante de 500 Mbps TX et un taux de données de liaison descendante de 100 Mb/s RX, et il est entièrement en conformité avec les standards TSMC 0.18 um CMOS dans un volume total de 0,8 mm2. Ainsi, la mesure de consommation d’énergie totale en mode full duplex est de 10,4 mW (5 mW à 100 Mb/s pour RX, et de 5,4 mW à 500 Mb/s ou 10,8 PJ / bits pour TX). Notre cinquième contribution est une collaboration avec l’Université McGill dans laquelle nous concevons des antennes simples et à double polarisation pour les systèmes de détection du cancer du sein à l’aide d’hyperfréquences sans fil en utilisant un modèle multi-couche et inhomogène du sein humain. Les antennes fabriquées à partir de matériaux flexibles sont plus facilement adaptées à des applications portables. Les antennes flexibles miniaturisées monopôles et spirales sur un 50 um Kapton polyimide sont conçus, en utilisant high frequency structure simulator (HFSS), à être en contact avec des tissus biologiques du sein. Les antennes proposées sont conçues pour fonctionner dans une gamme de fréquences de 2 à 4 GHz. Les mesures montrent que les antennes flexibles ont une bonne adaptation d’impédance dans les différentes positions sur le sein. De Plus, deux antennes à bande ultralarge flexibles 4 × 4 (simple et à double polarisation), dans un format similaire à celui d’un soutien-gorge, ont été développés pour un système de détection du cancer du sein basé sur le radar.We are working on a fully wireless brain-machine-interface to provide a communication link between the brain and external devices, enabling recording and stimulating the brain for permanent usage. In this thesis we explore channel modeling, implanted and wearable antennas as suitable propagators for this application, system level design of an implantable UWB transceiver, and circuit level design and implementing it by TSMC 0.18 um CMOS process. Also, in a collaboration project with McGill University, we designed a flexible sixteen antenna array for microwave breast cancer detection. Our first contribution calculates channel characteristics of implant-to-air UWB wireless link, average specific absorption rate (ASAR), and FCC guidelines on transmitted UWB power spectral density. Knowledge of channel behavior is required to determine the maximum allowable power to 1) respect ANSI guidelines for avoiding tissue damage and 2) respect FCC guidelines on unlicensed transmissions. We utilize a realistic model of the biological channel to inform the design of antennas for the implanted transmitter and the external receiver. Antennas placement is examined under two scenarios having contrasting power constraints. Performance of the system within the biological tissues is examined via simulations and experiments. Our second contribution deals with designing single and dual-polarization antennas for wireless ultra-wideband neural recording systems using an inhomogeneous multi-layer model of the human head. Antennas made from flexible materials are more easily adapted to implantation; we investigate both flexible and rigid materials and examine performance trade-offs. The proposed antennas are designed to operate in a frequency range of 2–11 GHz (having S11 below -10 dB) covering both the 2.45 GHz (ISM) band and the 3.1–10.6 GHz UWB band. Measurements confirm simulation results showing flexible antennas have little performance degradation due to bending effects (in terms of impedance matching). Finally, a comparison is made of four implantable antennas covering the 2-11 GHz range: 1) rigid, single polarization, 2) rigid, dual polarization, 3) flexible, single polarization and 4) flexible, dual polarization. In all cases a rigid antenna is used outside the body, with an appropriate polarization. Several advantages were confirmed for dual polarization antennas: 1) smaller size, 2) lower sensitivity to angular misalignments, and 3) higher fidelity. Our third contribution provides system level design of wireless communication architecture for implanted systems that simultaneously stimulate neurons and record neural responses. This architecture supports large numbers of electrodes (> 500), providing 100 Mb/s for the downlink of stimulation signals, and Gb/s for the uplink neural recordings. We propose a transceiver architecture that shares one ultra-wideband antenna, a streamlined transceiver working at full-duplex on both bands, and a novel pulse shaper for the Gb/s uplink supporting several modulation formats. We present an ex-vivo experimental demonstration of the architecture using discrete components achieving Gb/s uplink rates. Good bit error rate performance over a biological channel at 0.5, 1, and 2 Gbps data rates for uplink telemetry (UWB) and 100 Mbps for downlink telemetry (2.45 GHz band) is achieved. Our fourth contribution presents circuit level design of the novel full-duplex transceiver (FDT) which is presented in our third contribution. This full-duplex transceiver supports high-density and multimodal neural interfacing applications (high-channel count stimulating and recording) with asymmetric data rates. The transmitter (TX) and receiver (RX) share a single antenna to reduce implant size. The TX uses impulse radio ultra-wide band (IR-UWB) based on an edge combining approach, and the RX uses a novel 2.4-GHz on-off keying (OOK) receiver. Proper isolation (> 20 dB) between the TX and RX path is implemented 1) by shaping the transmitted pulses to fall within the unregulated UWB spectrum (3.1-7 GHz), and 2) by spaceefficient filtering (avoiding a circulator or diplexer) of the downlink OOK spectrum in the RX low-noise amplifier. The UWB 3.1-7 GHz transmitter can use either OOK or binary phase shift keying (BPSK) modulation schemes. The proposed FDT provides dual band 500-Mbps TX uplink data rate and 100 Mbps RX downlink data rate, and it is fully integrated into standard TSMC 0.18 um CMOS within a total size of 0.8 mm2. The total measured power consumption is 10.4 mW in full duplex mode (5 mW at 100 Mbps for RX, and 5.4 mW at 500 Mbps or 10.8 pJ/bit for TX). Our fifth contribution is a collaboration project with McGill University which we design single and dual-polarization antennas for wireless ultra-wideband breast cancer detection systems using an inhomogeneous multi-layer model of the human breast. Antennas made from flexible materials are more easily adapted to wearable applications. Miniaturized flexible monopole and spiral antennas on a 50 um Kapton polyimide are designed, using a high frequency structure simulator (HFSS), to be in contact with biological breast tissues. The proposed antennas are designed to operate in a frequency range of 2–4 GHz (with reflection coefficient (S11) below -10 dB). Measurements show that the flexible antennas have good impedance matching while in different positions with different curvature around the breast. Furthermore, two flexible conformal 4×4 ultra-wideband antenna arrays (single and dual polarization), in a format similar to that of a bra, were developed for a radar-based breast cancer detection system

RF energy harvesters for wireless sensors, state of the art, future prospects and challenges: a review

The power consumption of portable gadgets, implantable medical devices (IMDs) and wireless sensor nodes (WSNs) has reduced significantly with the ongoing progression in low-power electronics and the swift advancement in nano and microfabrication. Energy harvesting techniques that extract and convert ambient energy into electrical power have been favored to operate such low-power devices as an alternative to batteries. Due to the expanded availability of radio frequency (RF) energy residue in the surroundings, radio frequency energy harvesters (RFEHs) for low-power devices have garnered notable attention in recent times. This work establishes a review study of RFEHs developed for the utilization of low-power devices. From the modest single band to the complex multiband circuitry, the work reviews state of the art of required circuitry for RFEH that contains a receiving antenna, impedance matching circuit, and an AC-DC rectifier. Furthermore, the advantages and disadvantages associated with various circuit architectures are comprehensively discussed. Moreover, the reported receiving antenna, impedance matching circuit, and an AC-DC rectifier are also compared to draw conclusions towards their implementations in RFEHs for sensors and biomedical devices applications

PROPAGATION CHARACTERIZATION OF IMPLANTABLE ANTENNA AT UWB FREQUENCY – A REVIEW

A technology of wireless body area network (WBAN) was invented in order to enhance the quality of healthcare management as well as to determine faster disease prevention. However, to obtain the real-time data of images and videos from inside the human body, an implantable device is required. Currently, the Medical Implant Communication System (MICS) is used, but, this system has limited data rate which is a narrow-band of 402 – 405 MHz. Thus, this study on Ultra Wideband (UWB) for implanted device is conducted as UWB offers a wide transmission bandwidth as well as high data rate. Knowledge of radio wave propagation behaviour inside human body is needed to perform the implantation. Past researches related to this topic are limited and those conducted focused only on the human torso. This paper aims to provide a better understanding on the characteristics of radio wave propagation inside the human body by using an implantable device at UWB frequency. It is also hoped that this study could be used as reference for future research on this subject

Propagation characterization of implantable antenna at UWB frequency – a review

A technology of wireless body area network (WBAN) was invented in order to enhance the quality of healthcare management as well as to determine faster disease prevention. However, to obtain the real-time data of images and videos from inside the human body, an implantable device is required. Currently, the Medical Implant Communication System (MICS) is used, but, this system has limited data rate which is a narrow-band of 402 – 405 MHz. Thus, this study on Ultra Wideband (UWB) for implanted device is conducted as UWB offers a wide transmission bandwidth as well as high data rate. Knowledge of radio wave propagation behaviour inside human body is needed to perform the implantation. Past researches related to this topic are limited and those conducted focused only on the human torso. This paper aims to provide a better understanding on the characteristics of radio wave propagation inside the human body by using an implantable device at UWB frequency. It is also hoped that this study could be used as reference for future research on this subject

Biomedical telemetry: today's opportunities and challenges

Journal ArticleBiomedical telemetry is used today to communication with cardiac devices, insulin pumps, and a few other implantable devices that are on the order of 1-2" in diameter. Future systems promise advanced communication with cardiac, optical, neurological and auditory devices that are on the order of a centimeter in dimension. Miniaturized antennas and inductive coupling systems provide the radio interface between air and the implantable device. New materials and methods allow miniaturized communication systems to be seamlessly integrated within the medical device itself. This paper describes recent advances in biotelemetry, the challenges faced today, and opportunities for the future

A Compact Size Implantable Antenna for Bio-medical Applications

Implantable antennas play a vital role in implantable sensors and medical devices. In this paper, we present the design of a compact size implantable antenna for biomedical applications. The antenna is designed to operate in ISM band at 915 MHz and the overall size of the antenna is 4×4×0.3mm3. A shorting pin is used to lower the operating frequency of the antenna. For excitation purpose a 50-ohm coaxial probe feed is used in the design. A superstrate layer is placed on the patch to prevent the direct contact between the radiating patch and body tissues. The antenna is simulated in skin layer model. The designed antenna demonstrates a gain of 3.22 dBi while having a -10 dB bandwidth of 240 MHz with good radiation characteristics at 915 MHz. The simulated results show that this antenna is an excellent candidate for implantable applications

A Wideband Bear-Shaped Compact Size Implantable Antenna for In-Body Communications

Biomedical implantable antennas play a vital role in medical telemetry applications. These types of biomedical implantable devices are very helpful in improving and monitoring patients' living situations on a daily basis. In the present paper, a miniaturized footprint, thin-profile bear-shaped in-body antenna operational at 915 MHz in the industrial, scientific, and medical (ISM) band is proposed. The design is a straightforward bear-shaped truncated patch excited by a 50-W coaxial probe. The radiator is made up of two circular slots and one rectangular slot at the feet of the patch, and the ground plane is sotted to achieve a broadsided directional radiation pattern, imprinted on a Duroid RT5880 roger substrate with a typical 0.254-mm thickness ( er = 2.2, tan d = 0.0009). The stated antenna has a complete size of 7 mm x 7 mm x 0.254 mm and, in terms of guided wavelength, of 0.027lg x 0.027lg x 0.0011lg. When operating inside skin tissues, the antenna covers a measured bandwidth from 0.86 GHz to 1.08 GHz (220 MHz). The simulations and experimental outcomes of the stated design are in proper contract. The obtained results show that the calculated specific absorption rate (SAR) values inside skin of over 1 g of mass tissue is 8.22 W/kg. The stated SAR values are lower than the limitations of the federal communications commission (FCC). Thus, the proposed miniaturized antenna is an ultimate applicant for in-body communications.This project received funding from Universidad Carlos III de Madrid and the European Union’s Horizon 2020 research and innovation program, under the Marie Sklodowska-Curie Grant 801538. It also received partial funding from the Researchers Supporting Project number (RSP- 2021/399), King Saud University, Riyadh, Saudi Arabia