Stroke treatment academic industry roundtable recommendations for individual data pooling analyses in stroke

Pooled analysis of individual patient data from stroke trials can deliver more precise estimates of treatment effect, enhance power to examine prespecified subgroups, and facilitate exploration of treatment-modifying influences. Analysis plans should be declared, and preferably published, before trial results are known. For pooling trials that used diverse analytic approaches, an ordinal analysis is favored, with justification for considering deaths and severe disability jointly. Because trial pooling is an incremental process, analyses should follow a sequential approach, with statistical adjustment for iterations. Updated analyses should be published when revised conclusions have a clinical implication. However, caution is recommended in declaring pooled findings that may prejudice ongoing trials, unless clinical implications are compelling. All contributing trial teams should contribute to leadership, data verification, and authorship of pooled analyses. Development work is needed to enable reliable inferences to be drawn about individual drug or device effects that contribute to a pooled analysis, versus a class effect, if the treatment strategy combines ≥2 such drugs or devices. Despite the practical challenges, pooled analyses are powerful and essential tools in interpreting clinical trial findings and advancing clinical care

Automatic Metadata Generation using Associative Networks

In spite of its tremendous value, metadata is generally sparse and incomplete, thereby hampering the effectiveness of digital information services. Many of the existing mechanisms for the automated creation of metadata rely primarily on content analysis which can be costly and inefficient. The automatic metadata generation system proposed in this article leverages resource relationships generated from existing metadata as a medium for propagation from metadata-rich to metadata-poor resources. Because of its independence from content analysis, it can be applied to a wide variety of resource media types and is shown to be computationally inexpensive. The proposed method operates through two distinct phases. Occurrence and co-occurrence algorithms first generate an associative network of repository resources leveraging existing repository metadata. Second, using the associative network as a substrate, metadata associated with metadata-rich resources is propagated to metadata-poor resources by means of a discrete-form spreading activation algorithm. This article discusses the general framework for building associative networks, an algorithm for disseminating metadata through such networks, and the results of an experiment and validation of the proposed method using a standard bibliographic dataset

Overview of the author identification task at PAN 2014

The author identification task at PAN-2014 focuses on author verification. Similar to PAN-2013 we are given a set of documents by the same author along with exactly one document of questioned authorship, and the task is to determine whether the known and the questioned documents are by the same author or not. In comparison to PAN-2013, a significantly larger corpus was built comprising hundreds of documents in four natural languages (Dutch, English, Greek, and Spanish) and four genres (essays, reviews, novels, opinion articles). In addition, more suitable performance measures are used focusing on the accuracy and the confidence of the predictions as well as the ability of the submitted methods to leave some problems unanswered in case there is great uncertainty. To this end, we adopt the c@1 measure, originally proposed for the question answering task. We received 13 software submissions that were evaluated in the TIRA framework. Analytical evaluation results are presented where one language-independent approach serves as a challenging baseline. Moreover, we continue the successful practice of the PAN labs to examine meta-models based on the combination of all submitted systems. Last but not least, we provide statistical significance tests to demonstrate the important differences between the submitted approaches

Authorship attribution in portuguese using character N-grams

For the Authorship Attribution (AA) task, character n-grams are considered among the best predictive features. In the English language, it has also been shown that some types of character n-grams perform better than others. This paper tackles the AA task in Portuguese by examining the performance of different types of character n-grams, and various combinations of them. The paper also experiments with different feature representations and machine-learning algorithms. Moreover, the paper demonstrates that the performance of the character n-gram approach can be improved by fine-tuning the feature set and by appropriately selecting the length and type of character n-grams. This relatively simple and language-independent approach to the AA task outperforms both a bag-of-words baseline and other approaches, using the same corpus.Mexican Government (Conacyt) [240844, 20161958]; Mexican Government (SIP-IPN) [20171813, 20171344, 20172008]; Mexican Government (SNI); Mexican Government (COFAA-IPN)