471 research outputs found
Stochastic Calculus of Wrapped Compartments
The Calculus of Wrapped Compartments (CWC) is a variant of the Calculus of
Looping Sequences (CLS). While keeping the same expressiveness, CWC strongly
simplifies the development of automatic tools for the analysis of biological
systems. The main simplification consists in the removal of the sequencing
operator, thus lightening the formal treatment of the patterns to be matched in
a term (whose complexity in CLS is strongly affected by the variables matching
in the sequences).
We define a stochastic semantics for this new calculus. As an application we
model the interaction between macrophages and apoptotic neutrophils and a
mechanism of gene regulation in E.Coli
Process Calculi Abstractions for Biology
Several approaches have been proposed to model biological systems by means of the formal techniques and tools available in computer science. To mention just a few of them, some representations are inspired by Petri Nets theory, and some other by stochastic processes. A most recent approach consists in interpreting the living entities as terms of process calculi where the behavior of the represented systems can be inferred by applying syntax-driven rules. A comprehensive picture of the state of the art of the process calculi approach to biological modeling is still missing. This paper goes in the direction of providing such a picture by presenting a comparative survey of the process calculi that have been used and proposed to describe the behavior of living entities. This is the preliminary version of a paper that was published in Algorithmic Bioprocesses. The original publication is available at http://www.springer.com/computer/foundations/book/978-3-540-88868-
Modeling and Analyzing Biomolecular Networks
The authors argue for the need to model and analyze biological networks at molecular and cellular levels. They propose a computational toolbox for biologists. Central to their approach is the paradigm of hybrid models in which discrete events are combined with continuous differential equations to capture switching behavior
Parallel BioScape: A Stochastic and Parallel Language for Mobile and Spatial Interactions
BioScape is a concurrent language motivated by the biological landscapes
found at the interface of biology and biomaterials. It has been motivated by
the need to model antibacterial surfaces, biofilm formation, and the effect of
DNAse in treating and preventing biofilm infections. As its predecessor, SPiM,
BioScape has a sequential semantics based on Gillespie's algorithm, and its
implementation does not scale beyond 1000 agents. However, in order to model
larger and more realistic systems, a semantics that may take advantage of the
new multi-core and GPU architectures is needed. This motivates the introduction
of parallel semantics, which is the contribution of this paper: Parallel
BioScape, an extension with fully parallel semantics.Comment: In Proceedings MeCBIC 2012, arXiv:1211.347
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