An Experimental Study on the Vascular Lesions Caused by Disturbance of Microcirculation in the Aortic Wall : Influence of Obstruction of the Lymphatics in the Aorta and Periaortic Tissues

1975-09Distribution of the lymphatics and vascular changes caused by obstruction of the lymphatics in the aortic wall and periaortic tissues of dogs were investigated. By injecting India ink into the external iliac lymph nodes, the lymphatics in the aortic wall were observed in the superficial layer of the adventitia. Obstruction of the lymphatics in the aortic wall was produced by injecting a solution of gelatin.hydrocWoric acid into the external iliac lymph nodes. The dogs were divided into three groups. a) Ligated group Obstruction of the lymphatics and ligation of the illferior vena cava below the renal veins were performed. b) Not-ligated group Only the lymphatic obstruction was undertaken. c) Control group In general, accumulation of the interstitial fluids in the media, thickening of the intima and degeneration of the smooth muscle cells in the aortic wall were observed. At early phase, the ligated group showed more rapid and severe vascular changes than the not-ligated group. At late phase, no difference of changes was seen between the two group. Vascular changes were severe and lasted long in the region where granulation tissues increased markedly around the obstructed lymphatics. The above-mentioned facts suggest significance of the lymphatics related to vascular lesions.departmental bulletin pape

Spontaneous rupture of abdominal aorta — an unusual manifestation of an idiopathic cystic medial necrosis (Gsell-Erdheim syndrome) and literature overview

In this report, a case of a male, 40-year-old patient who suffered from spontaneous rupture of undilated abdominal aorta, a manifestation of idiopathic cystic media necrosis (Gsell-Erdheim syndrome), is presented. Spontaneous ruptures of medium-to-large arteries observed in this syndrome are a consequence of elastic fibres degeneration and glucose-amino-glycans (GAG) depositions in the arterial media. Gsell-Erdheim syndrome is also observed in a large portion of spontaneous aortic dissections. Histopathological criteria for the diagnosis of this disease, as well as clinical implications for current treatment, especially endovascular procedures in the aortic dissections, are discussed

Aortic remodelling in Fabry disease

Aims To evaluate thoracic aortic dilation in patients with Fabry disease (FD). Methods and results A cohort of 106 patients with FD (52 males; 54 females) from three European centres were studied. The diameter of the thoracic aorta was assessed at three levels (sinus of Valsalva, ascending aorta, and descending aorta) using echocardiograms and cardiovascular magnetic resonance imaging. Aortic dilation at the sinus of Valsalva was found in 32.7% of males and 5.6% of females; aneurysms were present in 9.6% of males and 1.9% of females. No aortic dilation was observed in the descending aorta. There was no correlation between aortic diameter at the sinus of Valsalva and cardiovascular risk factors. Conclusion Fabry disease should be considered as a cardiovascular disease that affects the heart and arterial vasculature, including the thoracic aorta. Thus, patients with FD should be closely monitored for the presence, and possible progression and complications of aortic dilation. Clinical Trial Registration: Protocol 101/01. Ethics committee, Faculty of Medicine, Lausann

Dissecting aneurysm

Detailed formal protocol with illustrations and extensive bibliography.UT Southwestern--Internal Medicin

Inflammatory Markers and Aortic Aneurysms: Exploring the Role of Hs-CRP and MHR in Ascending Aortic Aneurysm Development

Diyar Köprülü,1 Mohamed Omar Hassan,2 Hüsnü Atmaca,3 Sezgin Albayrak,1 Esra Işcanlı4 1Department of Cardiology, Ordu State Hospital, Ordu, Turkey; 2Department of Cardiology, Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, Somalia; 3Department of Cardiology, Samsun Gazi State Hospital, Samsun, Turkey; 4Department of Radiology, Ankara Bilkent Sehir Hospital, Ankara, TurkeyCorrespondence: Diyar Köprülü, Email [email protected]: Aortic aneurysms, particularly those affecting the ascending aorta, pose significant health risks due to their potential to cause life-threatening complications such as rupture and dissection. While the etiology of ascending aortic aneurysms has traditionally been associated with non-inflammatory processes, emerging evidence suggests a potential role of inflammation in their development.Methods: This study investigates the relationship between inflammatory markers and ascending aortic aneurysms, focusing on high-sensitivity C-reactive protein (hs-CRP) and the monocyte-to-HDL ratio (MHR). A total of 135 patients with ascending aortic aneurysms and 40 control subjects underwent comprehensive evaluations, including echocardiography, computed tomography imaging, and serum biomarker measurements.Results: The results indicate significantly elevated levels of hs-CRP and MHR in patients with ascending aortic aneurysms compared to the control group, suggesting a potential inflammatory component in the pathogenesis of these aneurysms. However, the precise mechanisms underlying this association remain to be elucidated.Conclusion: Despite limitations such as the cross-sectional study design and relatively small sample size, this study provides valuable insights into the potential involvement of inflammation in ascending aortic aneurysms. Further research, including longitudinal studies and histopathological analysis of aortic tissue, is warranted to confirm these findings and explore the utility of inflammatory markers as diagnostic and prognostic indicators in this patient population.Keywords: ascending aortic aneurysm, inflammation, hs-CRP, monocyte-to-HDL rati

Typ A Aortendissektion - Ergebnisse chirurgischer Therapie

Wir berichten über Ergebnisse der Operation bei Typ A Aortendissektion hinsichtlich 30d Letalität und neuen neurologischen Defiziten (NND) in Abhängigkeit vom Ort der Kanülierung. Es wurden Daten von 170 Patienten mit Typ A Aortendissektion zwischen 01.12.1999 und 31.12.2009 ausgewertet. Für die 30d Letalität waren die Ergebnisse bei Kanülierung der Aorta ascendens (9,1%; n=4 p=0,019) am besten. Bezüglich eines NND bestanden keine signifikanten Unterschiede zwischen den Kanülierungsarten. Risikofaktoren für 30d Letalität: Kreatinin (Intensivstation) (p<0,001), Anzahl TK (p=0,04), Low Cardiac Output Syndrom (p<0,01), Länge der OP (p<0,01), Bypass Zeit (p=0,01), ACT vor HLM (p=0,04), Reanimation (p<0,01), prä OP Hämatoperikard (p<0,01). Das 30 d Überleben begünstigende Faktoren: Arterieller Hypertonus (p=0,04), Kanülierung der Aorta ascendens (p=0,02). Die 30d Letalität betrug 22,4%, in 16,5% traten NND auf. Die Kanülierung der Aorta ascendens ist eine gute Alternative zur A. subclavia