From local laboratory data to public domain database in search of indirect association of diseases: AJAX based gene data search engine.

This paper presents an extensible schema for capturing laboratory gene variance data with its meta-data properties in a semi-structured environment. This paper also focuses on the issues of creating a local and task specific component database which is a subset of global data resources. An XML based genetic disorder component database schema is developed with adequate flexibilities to facilitate searching of gene mutation data. A web based search engine is developed that allows researchers to query a set of gene parameters obtained from local XML schema and subsequently allow them to automatically establish a link with the public domain gene databases. The application applies AJAX (Asynchronous Javascript and XML), a cutting-edge web technology, to carry out the gene data searching function

The Parallel Distributed Image Search Engine (ParaDISE)

Image retrieval is a complex task that differs according to the context and the user requirements in any specific field, for example in a medical environment. Search by text is often not possible or optimal and retrieval by the visual content does not always succeed in modelling high-level concepts that a user is looking for. Modern image retrieval techniques consists of multiple steps and aim to retrieve information from large–scale datasets and not only based on global image appearance but local features and if possible in a connection between visual features and text or semantics. This paper presents the Parallel Distributed Image Search Engine (ParaDISE), an image retrieval system that combines visual search with text–based retrieval and that is available as open source and free of charge. The main design concepts of ParaDISE are flexibility, expandability, scalability and interoperability. These concepts constitute the system, able to be used both in real–world applications and as an image retrieval research platform. Apart from the architecture and the implementation of the system, two use cases are described, an application of ParaDISE in retrieval of images from the medical literature and a visual feature evaluation for medical image retrieval. Future steps include the creation of an open source community that will contribute and expand this platform based on the existing parts

A Query Integrator and Manager for the Query Web

We introduce two concepts: the Query Web as a layer of interconnected queries over the document web and the semantic web, and a Query Web Integrator and Manager (QI) that enables the Query Web to evolve. QI permits users to write, save and reuse queries over any web accessible source, including other queries saved in other installations of QI. The saved queries may be in any language (e.g. SPARQL, XQuery); the only condition for interconnection is that the queries return their results in some form of XML. This condition allows queries to chain off each other, and to be written in whatever language is appropriate for the task. We illustrate the potential use of QI for several biomedical use cases, including ontology view generation using a combination of graph-based and logical approaches, value set generation for clinical data management, image annotation using terminology obtained from an ontology web service, ontology-driven brain imaging data integration, small-scale clinical data integration, and wider-scale clinical data integration. Such use cases illustrate the current range of applications of QI and lead us to speculate about the potential evolution from smaller groups of interconnected queries into a larger query network that layers over the document and semantic web. The resulting Query Web could greatly aid researchers and others who now have to manually navigate through multiple information sources in order to answer specific questions

Object reational data base management systems and applications in document retrieval

http://deepblue.lib.umich.edu/bitstream/2027.42/96902/1/MBA_JayaramanaF_1996Final.pd

From local laboratory data to public domain database in search of indirect association of diseases: AJAX based gene data search engine.

This paper presents an extensible schema for capturing laboratory gene variance data with its meta-data properties in a semi-structured environment. This paper also focuses on the issues of creating a local and task specific component database which is a subset of global data resources. An XML based genetic disorder component database schema is developed with adequate flexibilities to facilitate searching of gene mutation data. A web based search engine is developed that allows researchers to query a set of gene parameters obtained from local XML schema and subsequently allow them to automatically establish a link with the public domain gene databases. The application applies AJAX (Asynchronous Javascript and XML), a cutting-edge web technology, to carry out the gene data searching function

Data warehousing through multi-agent systems in the medical arena

Comunicação apresentada na International Conference on Knowledge Engineering and Decision Support, 1, Porto, 2004.In this paper it is presented AIDA, an Agency for Integration, Archive and Diffusion of Medical Information. It configures a data warehouse, developed using Multi-Agent technology, that integrates and archives information from heterogeneous sources of a health care unit. AIDA is like a symbiont, with a close association with core applications at any health care facility, namely the Picture Archive Communication System, the Radiological Information System and the Electronic Medical Record Information System, that are built upon pro-active agents and communicate with the AIDA’s ones

Use of a Fast Information Extraction Method as a Decision Support Tool

Ad-hoc extraction of information from documents can ensure the transparency of decisions made by an organization. Different Information Extraction methods have been applied to extract information from various domains. Most widely known methods use manually annotated training documents that require high development time. The automated training methods are not scalable to large application domains. We have developed a semi-automated knowledge-engineering method for building the knowledge-base with minimal efforts. Because our method reduces manual processing of the training data, the development process is very fast. We have developed a prototype application to extract information from the project-reports of the American Recovery and Reinvestment Act (ARRA) of 2009. The fast development process of our system, its scalability to large application domains, and its high extraction effectiveness will help the transparency of management decisions by extracting and mining relevant information

A Learning Health System for Radiation Oncology

The proposed research aims to address the challenges faced by clinical data science researchers in radiation oncology accessing, integrating, and analyzing heterogeneous data from various sources. The research presents a scalable intelligent infrastructure, called the Health Information Gateway and Exchange (HINGE), which captures and structures data from multiple sources into a knowledge base with semantically interlinked entities. This infrastructure enables researchers to mine novel associations and gather relevant knowledge for personalized clinical outcomes. The dissertation discusses the design framework and implementation of HINGE, which abstracts structured data from treatment planning systems, treatment management systems, and electronic health records. It utilizes disease-specific smart templates for capturing clinical information in a discrete manner. HINGE performs data extraction, aggregation, and quality and outcome assessment functions automatically, connecting seamlessly with local IT/medical infrastructure. Furthermore, the research presents a knowledge graph-based approach to map radiotherapy data to an ontology-based data repository using FAIR (Findable, Accessible, Interoperable, Reusable) concepts. This approach ensures that the data is easily discoverable and accessible for clinical decision support systems. The dissertation explores the ETL (Extract, Transform, Load) process, data model frameworks, ontologies, and provides a real-world clinical use case for this data mapping. To improve the efficiency of retrieving information from large clinical datasets, a search engine based on ontology-based keyword searching and synonym-based term matching tool was developed. The hierarchical nature of ontologies is leveraged to retrieve patient records based on parent and children classes. Additionally, patient similarity analysis is conducted using vector embedding models (Word2Vec, Doc2Vec, GloVe, and FastText) to identify similar patients based on text corpus creation methods. Results from the analysis using these models are presented. The implementation of a learning health system for predicting radiation pneumonitis following stereotactic body radiotherapy is also discussed. 3D convolutional neural networks (CNNs) are utilized with radiographic and dosimetric datasets to predict the likelihood of radiation pneumonitis. DenseNet-121 and ResNet-50 models are employed for this study, along with integrated gradient techniques to identify salient regions within the input 3D image dataset. The predictive performance of the 3D CNN models is evaluated based on clinical outcomes. Overall, the proposed Learning Health System provides a comprehensive solution for capturing, integrating, and analyzing heterogeneous data in a knowledge base. It offers researchers the ability to extract valuable insights and associations from diverse sources, ultimately leading to improved clinical outcomes. This work can serve as a model for implementing LHS in other medical specialties, advancing personalized and data-driven medicine