Dopamine-modulated dynamic cell assemblies generated by the GABAergic striatal microcircuit

The striatum, the principal input structure of the basal ganglia, is crucial to both motor control and learning. It receives convergent input from all over the neocortex, hippocampal formation, amygdala and thalamus, and is the primary recipient of dopamine in the brain. Within the striatum is a GABAergic microcircuit that acts upon these inputs, formed by the dominant medium-spiny projection neurons (MSNs) and fast-spiking interneurons (FSIs). There has been little progress in understanding the computations it performs, hampered by the non-laminar structure that prevents identification of a repeating canonical microcircuit. We here begin the identification of potential dynamically-defined computational elements within the striatum. We construct a new three-dimensional model of the striatal microcircuit's connectivity, and instantiate this with our dopamine-modulated neuron models of the MSNs and FSIs. A new model of gap junctions between the FSIs is introduced and tuned to experimental data. We introduce a novel multiple spike-train analysis method, and apply this to the outputs of the model to find groups of synchronised neurons at multiple time-scales. We find that, with realistic in vivo background input, small assemblies of synchronised MSNs spontaneously appear, consistent with experimental observations, and that the number of assemblies and the time-scale of synchronisation is strongly dependent on the simulated concentration of dopamine. We also show that feed-forward inhibition from the FSIs counter-intuitively increases the firing rate of the MSNs. Such small cell assemblies forming spontaneously only in the absence of dopamine may contribute to motor control problems seen in humans and animals following a loss of dopamine cells. (C) 2009 Elsevier Ltd. All rights reserved

Decoupling of brain function from structure reveals regional behavioral specialization in humans

The brain is an assembly of neuronal populations interconnected by structural pathways. Brain activity is expressed on and constrained by this substrate. Therefore, statistical dependencies between functional signals in directly connected areas can be expected higher. However, the degree to which brain function is bound by the underlying wiring diagram remains a complex question that has been only partially answered. Here, we introduce the structural-decoupling index to quantify the coupling strength between structure and function, and we reveal a macroscale gradient from brain regions more strongly coupled, to regions more strongly decoupled, than expected by realistic surrogate data. This gradient spans behavioral domains from lower-level sensory function to high-level cognitive ones and shows for the first time that the strength of structure-function coupling is spatially varying in line with evidence derived from other modalities, such as functional connectivity, gene expression, microstructural properties and temporal hierarchy

Balanced Quantization: An Effective and Efficient Approach to Quantized Neural Networks

Quantized Neural Networks (QNNs), which use low bitwidth numbers for representing parameters and performing computations, have been proposed to reduce the computation complexity, storage size and memory usage. In QNNs, parameters and activations are uniformly quantized, such that the multiplications and additions can be accelerated by bitwise operations. However, distributions of parameters in Neural Networks are often imbalanced, such that the uniform quantization determined from extremal values may under utilize available bitwidth. In this paper, we propose a novel quantization method that can ensure the balance of distributions of quantized values. Our method first recursively partitions the parameters by percentiles into balanced bins, and then applies uniform quantization. We also introduce computationally cheaper approximations of percentiles to reduce the computation overhead introduced. Overall, our method improves the prediction accuracies of QNNs without introducing extra computation during inference, has negligible impact on training speed, and is applicable to both Convolutional Neural Networks and Recurrent Neural Networks. Experiments on standard datasets including ImageNet and Penn Treebank confirm the effectiveness of our method. On ImageNet, the top-5 error rate of our 4-bit quantized GoogLeNet model is 12.7\%, which is superior to the state-of-the-arts of QNNs

Graph Convolutional Networks (GCNs) for Molecular Property Prediction in Drug Development

Molecular property prediction is key to drug development. The rising of deep learning techniques provides new possibilities to learn the molecular properties directly from chemical data. In particular, graph convolutional networks have been introduced into the field and made significant enhancements compared to traditional methods. The first part of this paper serves as a study to explore and evaluate this emerging method while the second part demonstrates that graph convolution networks can be further improved by incorporating attention mechanism, another influential deep learning idea.No embargoAcademic Major: Computer and Information Scienc

Activity Recognition and Prediction in Real Homes

In this paper, we present work in progress on activity recognition and prediction in real homes using either binary sensor data or depth video data. We present our field trial and set-up for collecting and storing the data, our methods, and our current results. We compare the accuracy of predicting the next binary sensor event using probabilistic methods and Long Short-Term Memory (LSTM) networks, include the time information to improve prediction accuracy, as well as predict both the next sensor event and its mean time of occurrence using one LSTM model. We investigate transfer learning between apartments and show that it is possible to pre-train the model with data from other apartments and achieve good accuracy in a new apartment straight away. In addition, we present preliminary results from activity recognition using low-resolution depth video data from seven apartments, and classify four activities - no movement, standing up, sitting down, and TV interaction - by using a relatively simple processing method where we apply an Infinite Impulse Response (IIR) filter to extract movements from the frames prior to feeding them to a convolutional LSTM network for the classification.Comment: 12 pages, Symposium of the Norwegian AI Society NAIS 201