Using algorithmic information theory and stochastic modeling to improve classification and evolutionary computation: a dissertation submitted to the department of computer science of the Universidad Autonoma de Madrid in partial fulfillment of the requirements for the degree of doctor of philosophy

Tesis doctoral inédita. Universidad Autónoma de Madrid, Escuela Politécnica Superior, junio de 200

Algorithms to Explore the Structure and Evolution of Biological Networks

High-throughput experimental protocols have revealed thousands of relationships amongst genes and proteins under various conditions. These putative associations are being aggressively mined to decipher the structural and functional architecture of the cell. One useful tool for exploring this data has been computational network analysis. In this thesis, we propose a collection of novel algorithms to explore the structure and evolution of large, noisy, and sparsely annotated biological networks. We first introduce two information-theoretic algorithms to extract interesting patterns and modules embedded in large graphs. The first, graph summarization, uses the minimum description length principle to find compressible parts of the graph. The second, VI-Cut, uses the variation of information to non-parametrically find groups of topologically cohesive and similarly annotated nodes in the network. We show that both algorithms find structure in biological data that is consistent with known biological processes, protein complexes, genetic diseases, and operational taxonomic units. We also propose several algorithms to systematically generate an ensemble of near-optimal network clusterings and show how these multiple views can be used together to identify clustering dynamics that any single solution approach would miss. To facilitate the study of ancient networks, we introduce a framework called ``network archaeology'') for reconstructing the node-by-node and edge-by-edge arrival history of a network. Starting with a present-day network, we apply a probabilistic growth model backwards in time to find high-likelihood previous states of the graph. This allows us to explore how interactions and modules may have evolved over time. In experiments with real-world social and biological networks, we find that our algorithms can recover significant features of ancestral networks that have long since disappeared. Our work is motivated by the need to understand large and complex biological systems that are being revealed to us by imperfect data. As data continues to pour in, we believe that computational network analysis will continue to be an essential tool towards this end

In vitro neuronal cultures on MEA: an engineering approach to study physiological and pathological brain networks

Reti neuronali accoppiate a matrici di microelettrodi: un metodo ingegneristico per studiare reti cerebrali in situazioni fisiologiche e patologich

Exploiting development to enhance the scalability of hardware evolution.

Evolutionary algorithms do not scale well to the large, complex circuit design problems typical of the real world. Although techniques based on traditional design decomposition have been proposed to enhance hardware evolution's scalability, they often rely on traditional domain knowledge that may not be appropriate for evolutionary search and might limit evolution's opportunity to innovate. It has been proposed that reliance on such knowledge can be avoided by introducing a model of biological development to the evolutionary algorithm, but this approach has not yet achieved its potential. Prior demonstrations of how development can enhance scalability used toy problems that are not indicative of evolving hardware. Prior attempts to apply development to hardware evolution have rarely been successful and have never explored its effect on scalability in detail. This thesis demonstrates that development can enhance scalability in hardware evolution, primarily through a statistical comparison of hardware evolution's performance with and without development using circuit design problems of various sizes. This is reinforced by proposing and demonstrating three key mechanisms that development uses to enhance scalability: the creation of modules, the reuse of modules, and the discovery of design abstractions. The thesis includes several minor contributions: hardware is evolved using a common reconfigurable architecture at a lower level of abstraction than reported elsewhere. It is shown that this can allow evolution to exploit the architecture more efficiently and perhaps search more effectively. Also the benefits of several features of developmental models are explored through the biases they impose on the evolutionary search. Features that are explored include the type of environmental context development uses and the constraints on symmetry and information transmission they impose, genetic operators that may improve the robustness of gene networks, and how development is mapped to hardware. Also performance is compared against contemporary developmental models

Advances in Evolutionary Algorithms

With the recent trends towards massive data sets and significant computational power, combined with evolutionary algorithmic advances evolutionary computation is becoming much more relevant to practice. Aim of the book is to present recent improvements, innovative ideas and concepts in a part of a huge EA field