Monte Carlo simulation with fixed steplength for diffusion processes in nonhomogeneous media

Monte Carlo simulation is one of the most important tools in the study of diffusion processes. For constant diffusion coefficients, an appropriate Gaussian distribution of particle's steplengths can generate exact results, when compared with integration of the diffusion equation. It is important to notice that the same method is completely erroneous when applied to non-homogeneous diffusion coefficients. A simple alternative, jumping at fixed steplengths with appropriate transition probabilities, produces correct results. Here, a model for diffusion of calcium ions in the neuromuscular junction of the crayfish is used as a test to compare Monte Carlo simulation with fixed and Gaussian steplength.Fil: Ruiz Barlett, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Físicas de Mar del Plata. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Físicas de Mar del Plata; ArgentinaFil: Hoyuelos, Miguel Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Físicas de Mar del Plata. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Físicas de Mar del Plata; ArgentinaFil: Martin, Hector Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Físicas de Mar del Plata. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Físicas de Mar del Plata; Argentin

Unexpected High Brightness Temperature 140 PC from the Core in the Jet of 3C 120

We present 1.7, 5, 15, 22 and 43 GHz polarimetric multi-epoch VLBA observations of the radio galaxy 3C 120. The higher frequency observations reveal a new component, not visible before April 2007, located 80 mas from the core (which corresponds to a deprojected distance of 140 pc), with a brightness temperature about 600 times higher than expected at such distances. This component (hereafter C80) is observed to remain stationary and to undergo small changes in its brightness temperature during more than two years of observations. A helical shocked jet model - and perhaps some flow acceleration - may explain the unusually high Tb of C80, but it seems unlikely that this corresponds to the usual shock that emerges from the core and travels downstream to the location of C80. It appears that some other intrinsic process in the jet, capable of providing a local burst in particle and/or magnetic field energy, may be responsible for the enhanced brightness temperature observed in C80, its sudden appearance in April 2007, and apparent stationarity.Comment: 5 pages, 5 figures Accepted to be published in ApJ Letter

Managed Aquifer Recharge as a Tool to Enhance Sustainable Groundwater Management in California

A growing population and an increased demand for water resources have resulted in a global trend of groundwater depletion. Arid and semi-arid climates are particularly susceptible, often relying on groundwater to support large population centers or irrigated agriculture in the absence of sufficient surface water resources. In an effort to increase the security of groundwater resources, managed aquifer recharge (MAR) programs have been developed and implemented globally. MAR is the approach of intentionally harvesting and infiltrating water to recharge depleted aquifer storage. California is a prime example of this growing problem, with three cities that have over a million residents and an agricultural industry that was valued at 47 billion dollars in 2015. The present-day groundwater overdraft of over 100 km3 (since 1962) indicates a clear disparity between surface water supply and water demand within the state. In the face of groundwater overdraft and the anticipated effects of climate change, many new MAR projects are being constructed or investigated throughout California, adding to those that have existed for decades. Some common MAR types utilized in California include injection wells, infiltration basins (also known as spreading basins, percolation basins, or recharge basins), and low-impact development. An emerging MAR type that is actively being investigated is the winter flooding of agricultural fields using existing irrigation infrastructure and excess surface water resources, known as agricultural MAR. California therefore provides an excellent case study to look at the historical use and performance of MAR, ongoing and emerging challenges, novel MAR applications, and the potential for expansion of MAR. Effective MAR projects are an essential tool for increasing groundwater security, both in California and on a global scale. This chapter aims to provide an overview of the most common MAR types and applications within the State of California and neighboring semi-arid regions

Inducing pinning states and localized patterns in a monolayer of laterally attracting adatoms

The so-called "entropic mechanism" for ordering noise-induced phase transitions has been formerly used to stabilize nanopatterns in a realistic model for a monolayer of laterally interacting adsorbates. Here, we use this mechanism to stabilize pinning states and induce stochastic localized patterns ("dissipative solitons") on the monolayer. The key to achieve that goal is to displace only one of the stable homogeneous states toward field values at which the lateral interactions can elicit stable nanopatterns. At larger noise intensities, the "soliton" locations fluctuate with larger amplitude. However, since more localized patterns are elicited by the noise, their motion becomes confined when looked at longer timescales.Fil: Mangioni, Sergio Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Físicas de Mar del Plata. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Físicas de Mar del Plata; ArgentinaFil: Roberto R. Deza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Físicas de Mar del Plata. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Físicas de Mar del Plata; Argentin

Assembly and functional analysis of an S/MAR based episome with the cystic fibrosis transmembrane conductance regulator gene

Improving the efficacy of gene therapy vectors is still an important goal toward the development of safe and efficient gene therapy treatments. S/MAR (scaffold/matrix attached region)-based vectors are maintained extra-chromosomally in numerous cell types, which is similar to viral-based vectors. Additionally, when established as an episome, they show a very high mitotic stability. In the present study we tested the idea that addition of an S/MAR element to a CFTR (cystic fibrosis transmembrane conductance regulator) expression vector, may allow the establishment of a CFTR episome in bronchial epithelial cells. Starting from the observation that the S/MAR vector pEPI-EGFP (enhanced green fluorescence protein) is maintained as an episome in human bronchial epithelial cells, we assembled the CFTR vector pBQ-S/MAR. This vector, transfected in bronchial epithelial cells with mutated CFTR, supported long term wt CFTR expression and activity, which in turn positively impacted on the assembly of tight junctions in polarized epithelial cells. Additionally, the recovery of intact pBQ-S/MAR, but not the parental vector lacking the S/MAR element, from transfected cells after extensive proliferation, strongly suggested that pBQ-S/MAR was established as an episome. These results add a new element, the S/MAR, that can be considered to improve the persistence and safety of gene therapy vectors for cystic fibrosis pulmonary disease

On the combination of omics data for prediction of binary outcomes

Enrichment of predictive models with new biomolecular markers is an important task in high-dimensional omic applications. Increasingly, clinical studies include several sets of such omics markers available for each patient, measuring different levels of biological variation. As a result, one of the main challenges in predictive research is the integration of different sources of omic biomarkers for the prediction of health traits. We review several approaches for the combination of omic markers in the context of binary outcome prediction, all based on double cross-validation and regularized regression models. We evaluate their performance in terms of calibration and discrimination and we compare their performance with respect to single-omic source predictions. We illustrate the methods through the analysis of two real datasets. On the one hand, we consider the combination of two fractions of proteomic mass spectrometry for the calibration of a diagnostic rule for the detection of early-stage breast cancer. On the other hand, we consider transcriptomics and metabolomics as predictors of obesity using data from the Dietary, Lifestyle, and Genetic determinants of Obesity and Metabolic syndrome (DILGOM) study, a population-based cohort, from Finland

Nonreactive solute transport in soil columns: classical and fractional-calculus modeling

Vertical nonreactive solute transport data collected in three laboratory soil columns (made out of sediment samples from the Pampean aquifer located southeast of the Buenos Aires province) are contrasted with the explicit solutions of two model 1D linear PDEs: the classical advection–dispersion equation (ADE), and a fractional advection–dispersion equation (FADE) which has proven to be a useful modeling tool for highly inhomogeneous media exhibiting nontrivial scaling laws. Whereas two of the samples turn out to be quite homogeneous (thus requiring a fractional-derivative order γ → 2), the third one is best described by a FADE with fractional-derivative order γ = 1.68. This example illustrates the FADE’s ability to reveal self-similar geometric structures inside the sample.Fil: Benavente, Micaela Andrea. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Matemática; ArgentinaFil: Deza, Roberto Raul. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Físicas de Mar del Plata. Universidad Nacional de Mar del Plata. Facultad de Cs.exactas y Naturales. Instituto de Investigaciones Físicas de Mar del Plata; ArgentinaFil: Grondona, Sebastian. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Geología de Costas y del Cuaternario. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto de Geología de Costas y del Cuaternario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mascioli, S.. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Geología de Costas y del Cuaternario. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto de Geología de Costas y del Cuaternario; ArgentinaFil: Martinez, Daniel Emilio. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Geología de Costas y del Cuaternario. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto de Geología de Costas y del Cuaternario; Argentin

On sectional paths in a category of complexes of fixed size

We show how to build the Auslander-Reiten quiver of the category Cn(proj A)of complexes of size n ≥ 2, for any artin algebra A. We also give conditions over the complexes in Cn(proj A) under which the composition of irreducible morphisms in sectional paths vanishes.Fil: Chaio, Claudia Alicia. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Pratti, Nilda Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata; ArgentinaFil: Souto-Salorio, M. José. Universidad de Coruña; Españ