The DECIDE Project: Designing and Implementing a Prototype Service for Supporting Early Diagnosis of Alzheimer's Disease

This paper will present the design and implementation challenges of the innovative DECIDE service, to support research and early diagnosis of Alzheimer’s and other neurodegenerative diseases. DECIDE service, which is based on a Grid eInfrastructure, offers a set of tools providing quantitative measurements, to help researchers and clinicians make more informed diagnosis. As the service specifically targets the clinical community, it differs significantly from other initiatives since it needs to comply with the requirements imposed by the clinical routine in terms of accuracy, robustness, ease of use, data handling policies, adherence to clinical praxis. Moreover, sustainability aspects will also be discussed, since DECIDE aims to propose such service as a reference at European level, possibly extending it to other pathologies. We will then summarize the main results obtained to date, and the possible future developments

Towards an Integrative Formative Approach of Data-Driven Decision Making, Assessment for Learning, and Diagnostic Testing

This study concerns the comparison of three approaches to assessment: Data-Driven Decision Making, Assessment for Learning, and Diagnostic Testing. Although the three approaches claim to be beneficial with regard to student learning, no clear study into the relationships and distinctions between these approaches exists to date. The goal of this study was to investigate the extent to which the three approaches can be shaped into an integrative formative approach towards assessment. The three approaches were compared on nine characteristics of assessment. The results suggest that although the approaches seem to be contradictory with respect to some characteristics, it is argued that they could complement each other despite these differences. The researchers discuss how the three approaches can be shaped into an integrative formative approach towards assessmen

Case studies of personalized learning

Deliverable 4.1, Literature review of personalised learning and the Cloud, started with an evaluation and synthesis of the definitions of personalized learning, followed by an analysis of how this is implemented in a method (e-learning vs. i-learning, m-learning and u-learning), learning approach and the appropriate didactic process, based on adapted didactic theories. From this research a list of criteria was created needed to implement personalised learning onto the learner of the future. This list of criteria is the basis for the analysis of all case studies investigated. – as well to the learning process as the learning place. In total 60 case studies (all 59 case studies mentioned in D6.4 Education on the Cloud 2015 + one extra) were analysed. The case studies were compared with the list of criteria, and a score was calculated. As a result, the best examples could be retained. On average most case studies were good on: taking different learning methods into account, interactivity and accessibility and usability of learning materials for everyone. All had a real formal education content, thus aiming at the core-curriculum, valuing previous knowledge, competences, life and work skills, also informal. Also the availability of an instructor / tutor or other network of peers, experts and teachers to guide and support the learning is common. On the other hand, most case studies lack diagnostics tests as well at the start (diagnostic entry test), during the personalized learning trajectory and at the end (assessment at the end). Also most do not include non-formal and informal learning aspects. And the ownership of personalized learning is not in the hands of the learner. Five of the 60 case studies can as a result be considered as very good examples of real personalized learning

Ten Criteria for Meaningful and Usable Measures of Performance

Outlines requirements for healthcare delivery performance measures and their rationale, including prioritizing consumer and purchaser needs, using direct feedback, creating a comprehensive dashboard of measures, and measuring performance at all levels

Real-time motion analytics during brain MRI improve data quality and reduce costs

Head motion systematically distorts clinical and research MRI data. Motion artifacts have biased findings from many structural and functional brain MRI studies. An effective way to remove motion artifacts is to exclude MRI data frames affected by head motion. However, such post-hoc frame censoring can lead to data loss rates of 50% or more in our pediatric patient cohorts. Hence, many scanner operators collect additional 'buffer data', an expensive practice that, by itself, does not guarantee sufficient high-quality MRI data for a given participant. Therefore, we developed an easy-to-setup, easy-to-use Framewise Integrated Real-time MRI Monitoring (FIRMM) software suite that provides scanner operators with head motion analytics in real-time, allowing them to scan each subject until the desired amount of low-movement data has been collected. Our analyses show that using FIRMM to identify the ideal scan time for each person can reduce total brain MRI scan times and associated costs by 50% or more

A reusable rocket engine intelligen control

An intelligent control system for reusable space propulsion systems for future launch vehicles is described. The system description includes a framework for the design. The framework consists of an execution level with high-speed control and diagnostics, and a coordination level which marries expert system concepts with traditional control. A comparison is made between air breathing and rocket engine control concepts to assess the relative levels of development and to determine the applicability of air breathing control concepts to future reusable rocket engine systems

Approaching Economic Issues through Epidemiology–An Introduction to Business Epidemiology

In the tradition of transferring models and concepts from one science to another, our research explores the possibility of importing some concepts, definitions and approaches from human epidemiology to economic research, based on the extensive usage of medical terms and concepts in economy. The article explores some basic epidemiology concepts and their possible relevance to economic research, with the final goal to provide a new viewpoint over the economic phenomena, usable in economic crisis. The article introduces the concept of “business epidemiology” as a possible scientific approach to the economic crisis.epidemiology; business disease; company health; research methodology; financial contagion

Multivariate pattern classification of pediatric Tourette syndrome using functional connectivity MRI

Tourette syndrome (TS) is a developmental neuropsychiatric disorder characterized by motor and vocal tics. Individuals with TS would benefit greatly from advances in prediction of symptom timecourse and treatment effectiveness. As a first step, we applied a multivariate method - support vector machine (SVM) classification - to test whether patterns in brain network activity, measured with resting state functional connectivity (RSFC) MRI, could predict diagnostic group membership for individuals. RSFC data from 42 children with TS (8-15 yrs) and 42 unaffected controls (age, IQ, in-scanner movement matched) were included. While univariate tests identified no significant group differences, SVM classified group membership with ~70% accuracy (p < .001). We also report a novel adaptation of SVM binary classification that, in addition to an overall accuracy rate for the SVM, provides a confidence measure for the accurate classification of each individual. Our results support the contention that multivariate methods can better capture the complexity of some brain disorders, and hold promise for predicting prognosis and treatment outcome for individuals with TS