Forum on immune digital twins: a meeting report

Medical digital twins are computational models of human biology relevant to a given medical condition, which can be tailored to an individual patient, thereby predicting the course of disease and individualized treatments, an important goal of personalized medicine. The immune system, which has a central role in many diseases, is highly heterogeneous between individuals, and thus poses a major challenge for this technology. If medical digital twins are to faithfully capture the characteristics of a patient's immune system, we need to answer many questions, such as: What do we need to know about the immune system to build mathematical models that reflect features of an individual? What data do we need to collect across the different scales of immune system action? What are the right modeling paradigms to properly capture immune system complexity? In February 2023, an international group of experts convened in Lake Nona, FL for two days to discuss these and other questions related to digital twins of the immune system. The group consisted of clinicians, immunologists, biologists, and mathematical modelers, representative of the interdisciplinary nature of medical digital twin development. A video recording of the entire event is available. This paper presents a synopsis of the discussions, brief descriptions of ongoing digital twin projects at different stages of progress. It also proposes a 5-year action plan for further developing this technology. The main recommendations are to identify and pursue a small number of promising use cases, to develop stimulation-specific assays of immune function in a clinical setting, and to develop a database of existing computational immune models, as well as advanced modeling technology and infrastructure

Swarm intelligence for clustering dynamic data sets for web usage mining and personalization.

Swarm Intelligence (SI) techniques were inspired by bee swarms, ant colonies, and most recently, bird flocks. Flock-based Swarm Intelligence (FSI) has several unique features, namely decentralized control, collaborative learning, high exploration ability, and inspiration from dynamic social behavior. Thus FSI offers a natural choice for modeling dynamic social data and solving problems in such domains. One particular case of dynamic social data is online/web usage data which is rich in information about user activities, interests and choices. This natural analogy between SI and social behavior is the main motivation for the topic of investigation in this dissertation, with a focus on Flock based systems which have not been well investigated for this purpose. More specifically, we investigate the use of flock-based SI to solve two related and challenging problems by developing algorithms that form critical building blocks of intelligent personalized websites, namely, (i) providing a better understanding of the online users and their activities or interests, for example using clustering techniques that can discover the groups that are hidden within the data; and (ii) reducing information overload by providing guidance to the users on websites and services, typically by using web personalization techniques, such as recommender systems. Recommender systems aim to recommend items that will be potentially liked by a user. To support a better understanding of the online user activities, we developed clustering algorithms that address two challenges of mining online usage data: the need for scalability to large data and the need to adapt cluster sing to dynamic data sets. To address the scalability challenge, we developed new clustering algorithms using a hybridization of traditional Flock-based clustering with faster K-Means based partitional clustering algorithms. We tested our algorithms on synthetic data, real VCI Machine Learning repository benchmark data, and a data set consisting of real Web user sessions. Having linear complexity with respect to the number of data records, the resulting algorithms are considerably faster than traditional Flock-based clustering (which has quadratic complexity). Moreover, our experiments demonstrate that scalability was gained without sacrificing quality. To address the challenge of adapting to dynamic data, we developed a dynamic clustering algorithm that can handle the following dynamic properties of online usage data: (1) New data records can be added at any time (example: a new user is added on the site); (2) Existing data records can be removed at any time. For example, an existing user of the site, who no longer subscribes to a service, or who is terminated because of violating policies; (3) New parts of existing records can arrive at any time or old parts of the existing data record can change. The user\u27s record can change as a result of additional activity such as purchasing new products, returning a product, rating new products, or modifying the existing rating of a product. We tested our dynamic clustering algorithm on synthetic dynamic data, and on a data set consisting of real online user ratings for movies. Our algorithm was shown to handle the dynamic nature of data without sacrificing quality compared to a traditional Flock-based clustering algorithm that is re-run from scratch with each change in the data. To support reducing online information overload, we developed a Flock-based recommender system to predict the interests of users, in particular focusing on collaborative filtering or social recommender systems. Our Flock-based recommender algorithm (FlockRecom) iteratively adjusts the position and speed of dynamic flocks of agents, such that each agent represents a user, on a visualization panel. Then it generates the top-n recommendations for a user based on the ratings of the users that are represented by its neighboring agents. Our recommendation system was tested on a real data set consisting of online user ratings for a set of jokes, and compared to traditional user-based Collaborative Filtering (CF). Our results demonstrated that our recommender system starts performing at the same level of quality as traditional CF, and then, with more iterations for exploration, surpasses CF\u27s recommendation quality, in terms of precision and recall. Another unique advantage of our recommendation system compared to traditional CF is its ability to generate more variety or diversity in the set of recommended items. Our contributions advance the state of the art in Flock-based 81 for clustering and making predictions in dynamic Web usage data, and therefore have an impact on improving the quality of online services

Background, Systematic Review, Challenges and Outlook

Publisher Copyright: © 2013 IEEE. This research is supported by the Digital Manufacturing and Design Training Network (DiManD) project funded by the European Union through the Marie Skłodowska-Curie Innovative Training Networks (H2020-MSCA-ITN-2018) under grant agreement no. 814078The concept of smart manufacturing has attracted huge attention in the last years as an answer to the increasing complexity, heterogeneity, and dynamism of manufacturing ecosystems. This vision embraces the notion of autonomous and self-organized elements, capable of self-management and self-decision-making under a context-aware and intelligent infrastructure. While dealing with dynamic and uncertain environments, these solutions are also contributing to generating social impact and introducing sustainability into the industrial equation thanks to the development of task-specific resources that can be easily adapted, re-used, and shared. A lot of research under the context of self-organization in smart manufacturing has been produced in the last decade considering different methodologies and developed under different contexts. Most of these works are still in the conceptual or experimental stage and have been developed under different application scenarios. Thus, it is necessary to evaluate their design principles and potentiate their results. The objective of this paper is threefold. First, to introduce the main ideas behind self-organization in smart manufacturing. Then, through a systematic literature review, describe the current status in terms of technological and implementation details, mechanisms used, and some of the potential future research directions. Finally, the presentation of an outlook that summarizes the main results of this work and their interrelation to facilitate the development of self-organized manufacturing solutions. By providing a holistic overview of the field, we expect that this work can be used by academics and practitioners as a guide to generate awareness of possible requirements, industrial challenges, and opportunities that future self-organizing solutions can have towards a smart manufacturing transition.publishersversionpublishe

Uncovering Bias in Personal Informatics

Personal informatics (PI) systems, powered by smartphones and wearables, enable people to lead healthier lifestyles by providing meaningful and actionable insights that break down barriers between users and their health information. Today, such systems are used by billions of users for monitoring not only physical activity and sleep but also vital signs and women's and heart health, among others. %Despite their widespread usage, the processing of particularly sensitive personal data, and their proximity to domains known to be susceptible to bias, such as healthcare, bias in PI has not been investigated systematically. Despite their widespread usage, the processing of sensitive PI data may suffer from biases, which may entail practical and ethical implications. In this work, we present the first comprehensive empirical and analytical study of bias in PI systems, including biases in raw data and in the entire machine learning life cycle. We use the most detailed framework to date for exploring the different sources of bias and find that biases exist both in the data generation and the model learning and implementation streams. According to our results, the most affected minority groups are users with health issues, such as diabetes, joint issues, and hypertension, and female users, whose data biases are propagated or even amplified by learning models, while intersectional biases can also be observed

Personalized question-based cybersecurity recommendation systems

En ces temps de pandémie Covid19, une énorme quantité de l’activité humaine est modifiée pour se faire à distance, notamment par des moyens électroniques. Cela rend plusieurs personnes et services vulnérables aux cyberattaques, d’où le besoin d’une éducation généralisée ou du moins accessible sur la cybersécurité. De nombreux efforts sont entrepris par les chercheurs, le gouvernement et les entreprises pour protéger et assurer la sécurité des individus contre les pirates et les cybercriminels. En raison du rôle important joué par les systèmes de recommandation dans la vie quotidienne de l'utilisateur, il est intéressant de voir comment nous pouvons combiner les systèmes de cybersécurité et de recommandation en tant que solutions alternatives pour aider les utilisateurs à comprendre les cyberattaques auxquelles ils peuvent être confrontés. Les systèmes de recommandation sont couramment utilisés par le commerce électronique, les réseaux sociaux et les plateformes de voyage, et ils sont basés sur des techniques de systèmes de recommandation traditionnels. Au vu des faits mentionnés ci-dessus, et le besoin de protéger les internautes, il devient important de fournir un système personnalisé, qui permet de partager les problèmes, d'interagir avec un système et de trouver des recommandations. Pour cela, ce travail propose « Cyberhelper », un système de recommandation de cybersécurité personnalisé basé sur des questions pour la sensibilisation à la cybersécurité. De plus, la plateforme proposée est équipée d'un algorithme hybride associé à trois différents algorithmes basés sur la connaissance, les utilisateurs et le contenu qui garantit une recommandation personnalisée optimale en fonction du modèle utilisateur et du contexte. Les résultats expérimentaux montrent que la précision obtenue en appliquant l'algorithme proposé est bien supérieure à la précision obtenue en utilisant d'autres mécanismes de système de recommandation traditionnels. Les résultats suggèrent également qu'en adoptant l'approche proposée, chaque utilisateur peut avoir une expérience utilisateur unique, ce qui peut l'aider à comprendre l'environnement de cybersécurité.With the proliferation of the virtual universe and the multitude of services provided by the World Wide Web, a major concern arises: Security and privacy have never been more in jeopardy. Nowadays, with the Covid 19 pandemic, the world faces a new reality that pushed the majority of the workforce to telecommute. This thereby creates new vulnerabilities for cyber attackers to exploit. It’s important now more than ever, to educate and offer guidance towards good cybersecurity hygiene. In this context, a major effort has been dedicated by researchers, governments, and businesses alike to protect people online against hackers and cybercriminals. With a focus on strengthening the weakest link in the cybersecurity chain which is the human being, educational and awareness-raising tools have been put to use. However, most researchers focus on the “one size fits all” solutions which do not focus on the intricacies of individuals. This work aims to overcome that by contributing a personalized question-based recommender system. Named “Cyberhelper”, this work benefits from an existing mature body of research on recommender system algorithms along with recent research on non-user-specific question-based recommenders. The reported proof of concept holds potential for future work in adapting Cyberhelper as an everyday assistant for different types of users and different contexts

Computer Science & Technology Series : XXI Argentine Congress of Computer Science. Selected papers

CACIC’15 was the 21thCongress in the CACIC series. It was organized by the School of Technology at the UNNOBA (North-West of Buenos Aires National University) in Junín, Buenos Aires. The Congress included 13 Workshops with 131 accepted papers, 4 Conferences, 2 invited tutorials, different meetings related with Computer Science Education (Professors, PhD students, Curricula) and an International School with 6 courses. CACIC 2015 was organized following the traditional Congress format, with 13 Workshops covering a diversity of dimensions of Computer Science Research. Each topic was supervised by a committee of 3-5 chairs of different Universities. The call for papers attracted a total of 202 submissions. An average of 2.5 review reports werecollected for each paper, for a grand total of 495 review reports that involved about 191 different reviewers. A total of 131 full papers, involving 404 authors and 75 Universities, were accepted and 24 of them were selected for this book.Red de Universidades con Carreras en Informática (RedUNCI

Computer Science & Technology Series : XXI Argentine Congress of Computer Science. Selected papers

CACIC’15 was the 21thCongress in the CACIC series. It was organized by the School of Technology at the UNNOBA (North-West of Buenos Aires National University) in Junín, Buenos Aires. The Congress included 13 Workshops with 131 accepted papers, 4 Conferences, 2 invited tutorials, different meetings related with Computer Science Education (Professors, PhD students, Curricula) and an International School with 6 courses. CACIC 2015 was organized following the traditional Congress format, with 13 Workshops covering a diversity of dimensions of Computer Science Research. Each topic was supervised by a committee of 3-5 chairs of different Universities. The call for papers attracted a total of 202 submissions. An average of 2.5 review reports werecollected for each paper, for a grand total of 495 review reports that involved about 191 different reviewers. A total of 131 full papers, involving 404 authors and 75 Universities, were accepted and 24 of them were selected for this book.Red de Universidades con Carreras en Informática (RedUNCI

Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go

The advent of Precision Medicine has globally revolutionized the approach of translational research suggesting a patient-centric vision with therapeutic choices driven by the identification of specific predictive biomarkers of response to avoid ineffective therapies and reduce adverse effects. The spread of "multi-omics" analysis and the use of sensors, together with the ability to acquire clinical, behavioral, and environmental information on a large scale, will allow the digitization of the state of health or disease of each person, and the creation of a global health management system capable of generating real-time knowledge and new opportunities for prevention and therapy in the individual person (high-definition medicine). Real world data-based translational applications represent a promising alternative to the traditional evidence-based medicine (EBM) approaches that are based on the use of randomized clinical trials to test the selected hypothesis. Multi-modality data integration is necessary for example in precision oncology where an Avatar interface allows several simulations in order to define the best therapeutic scheme for each cancer patient

Logic-based Technologies for Intelligent Systems: State of the Art and Perspectives

Together with the disruptive development of modern sub-symbolic approaches to artificial intelligence (AI), symbolic approaches to classical AI are re-gaining momentum, as more and more researchers exploit their potential to make AI more comprehensible, explainable, and therefore trustworthy. Since logic-based approaches lay at the core of symbolic AI, summarizing their state of the art is of paramount importance now more than ever, in order to identify trends, benefits, key features, gaps, and limitations of the techniques proposed so far, as well as to identify promising research perspectives. Along this line, this paper provides an overview of logic-based approaches and technologies by sketching their evolution and pointing out their main application areas. Future perspectives for exploitation of logic-based technologies are discussed as well, in order to identify those research fields that deserve more attention, considering the areas that already exploit logic-based approaches as well as those that are more likely to adopt logic-based approaches in the future