Automatically linking MEDLINE abstracts to the Gene Ontology

Much has been written recently about the need for effective tools and methods for mining the wealth of information present in biomedical literature (Mack and Hehenberger, 2002; Blagosklonny and Pardee, 2001; Rindflesch et al., 2002)—the activity of conceptual biology. Keyword search engines operating over large electronic document stores (such as PubMed and the PNAS) offer some help, but there are fundamental obstacles that limit their effectiveness. In the first instance, there is no general consensus among scientists about the vernacular to be used when describing research about genes, proteins, drugs, diseases, tissues and therapies, making it very difficult to formulate a search query that retrieves the right documents. Secondly, finding relevant articles is just one aspect of the investigative process. A more fundamental goal is to establish links and relationships between facts existing in published literature in order to “validate current hypotheses or to generate new ones” (Barnes and Robertson, 2002)—something keyword search engines do little to support

The Semantic Web: Apotheosis of annotation, but what are its semantics?

This article discusses what kind of entity the proposed Semantic Web (SW) is, principally by reference to the relationship of natural language structure to knowledge representation (KR). There are three distinct views on this issue. The first is that the SW is basically a renaming of the traditional AI KR task, with all its problems and challenges. The second view is that the SW will be, at a minimum, the World Wide Web with its constituent documents annotated so as to yield their content, or meaning structure, more directly. This view makes natural language processing central as the procedural bridge from texts to KR, usually via some form of automated information extraction. The third view is that the SW is about trusted databases as the foundation of a system of Web processes and services. There's also a fourth view, which is much more difficult to define and discuss: If the SW just keeps moving as an engineering development and is lucky, then real problems won't arise. This article is part of a special issue called Semantic Web Update