A Novel Ontology and Machine Learning Driven Hybrid Clinical Decision Support Framework for Cardiovascular Preventative Care

Clinical risk assessment of chronic illnesses is a challenging and complex task which requires the utilisation of standardised clinical practice guidelines and documentation procedures in order to ensure consistent and efficient patient care. Conventional cardiovascular decision support systems have significant limitations, which include the inflexibility to deal with complex clinical processes, hard-wired rigid architectures based on branching logic and the inability to deal with legacy patient data without significant software engineering work. In light of these challenges, we are proposing a novel ontology and machine learning-driven hybrid clinical decision support framework for cardiovascular preventative care. An ontology-inspired approach provides a foundation for information collection, knowledge acquisition and decision support capabilities and aims to develop context sensitive decision support solutions based on ontology engineering principles. The proposed framework incorporates an ontology-driven clinical risk assessment and recommendation system (ODCRARS) and a Machine Learning Driven Prognostic System (MLDPS), integrated as a complete system to provide a cardiovascular preventative care solution. The proposed clinical decision support framework has been developed under the close supervision of clinical domain experts from both UK and US hospitals and is capable of handling multiple cardiovascular diseases. The proposed framework comprises of two novel key components: (1) ODCRARS (2) MLDPS. The ODCRARS is developed under the close supervision of consultant cardiologists Professor Calum MacRae from Harvard Medical School and Professor Stephen Leslie from Raigmore Hospital in Inverness, UK. The ODCRARS comprises of various components, which include: (a) Ontology-driven intelligent context-aware information collection for conducting patient interviews which are driven through a novel clinical questionnaire ontology. (b) A patient semantic profile, is generated using patient medical records which are collated during patient interviews (conducted through an ontology-driven context aware adaptive information collection component). The semantic transformation of patients’ medical data is carried out through a novel patient semantic profile ontology in order to give patient data an intrinsic meaning and alleviate interoperability issues with third party healthcare systems. (c) Ontology driven clinical decision support comprises of a recommendation ontology and a NICE/Expert driven clinical rules engine. The recommendation ontology is developed using clinical rules provided by the consultant cardiologist from the US hospital. The recommendation ontology utilises the patient semantic profile for lab tests and medication recommendation. A clinical rules engine is developed to implement a cardiac risk assessment mechanism for various cardiovascular conditions. The clinical rules engine is also utilised to control the patient flow within the integrated cardiovascular preventative care solution. The machine learning-driven prognostic system is developed in an iterative manner using state of the art feature selection and machine learning techniques. A prognostic model development process is exploited for the development of MLDPS based on clinical case studies in the cardiovascular domain. An additional clinical case study in the breast cancer domain is also carried out for the development and validation purposes. The prognostic model development process is general enough to handle a variety of healthcare datasets which will enable researchers to develop cost effective and evidence based clinical decision support systems. The proposed clinical decision support framework also provides a learning mechanism based on machine learning techniques. Learning mechanism is provided through exchange of patient data amongst the MLDPS and the ODCRARS. The machine learning-driven prognostic system is validated using Raigmore Hospital's RACPC, heart disease and breast cancer clinical case studies

A Self Regulating and Crowdsourced Indoor Positioning System through Wi-Fi Fingerprinting for Multi Storey Building

[EN] Unobtrusive indoor location systems must rely on methods that avoid the deployment of large hardware infrastructures or require information owned by network administrators. Fingerprinting methods can work under these circumstances by comparing the real-time received RSSI values of a smartphone coming from existing Wi-Fi access points with a previous database of stored values with known locations. Under the fingerprinting approach, conventional methods suffer from large indoor scenarios since the number of fingerprints grows with the localization area. To that aim, fingerprinting-based localization systems require fast machine learning algorithms that reduce the computational complexity when comparing real-time and stored values. In this paper, popular machine learning (ML) algorithms have been implemented for the classification of real time RSSI values to predict the user location and propose an intelligent indoor positioning system (I-IPS). The proposed I-IPS has been integrated with multi-agent framework for betterment of context-aware service (CAS). The obtained results have been analyzed and validated through established statistical measurements and superior performance achieved

Context-Aware Design of Cyber-Physical Human Systems (CPHS)

Recently, it has been widely accepted by the research community that interactions between humans and cyber-physical infrastructures have played a significant role in determining the performance of the latter. The existing paradigm for designing cyber-physical systems for optimal performance focuses on developing models based on historical data. The impacts of context factors driving human system interaction are challenging and are difficult to capture and replicate in existing design models. As a result, many existing models do not or only partially address those context factors of a new design owing to the lack of capabilities to capture the context factors. This limitation in many existing models often causes performance gaps between predicted and measured results. We envision a new design environment, a cyber-physical human system (CPHS) where decision-making processes for physical infrastructures under design are intelligently connected to distributed resources over cyberinfrastructure such as experiments on design features and empirical evidence from operations of existing instances. The framework combines existing design models with context-aware design-specific data involving human-infrastructure interactions in new designs, using a machine learning approach to create augmented design models with improved predictive powers.Comment: Paper was accepted at the 12th International Conference on Communication Systems and Networks (COMSNETS 2020

AN INVESTIGATION INTO CONTEXT-AWARE AUTOMATED SERVICE IN SMART HOME FACILITIES: SEARCH ENGINE AND MACHINE LEARNING WITH SMARTPHONE

Technological advances, in general, coupled with the widespread use of smartphones, create ever more opportunities for mobile applications. This thesis considers the use of such devices within embedded systems to provide automated services in smart home automation. The overall approach links together context-aware data from the physical environment, sensors and actuators for domestic appliances and statistics-based decision-making. A prototype system named ‘Wireless Sensor/Actuator Mobile Computing in the Smart Home’ (WiSAMCinSH) is developed, which in turns aims to provide services that can benefit clients who are currently dependent on others in their daily activities. This research highlights and covers the following concepts. Firstly, it addresses the need to improve the prototypical decision-making model by enabling it to take into account context-aware information as conditions under which particular action decisions are appropriate. Secondly, an essential aspect of context-aware performance architecture is that its features must be of high accuracy, explicitly readable and fast. Thirdly, it is necessary to determine which probability-based rules are most effective in generating the dynamic environment to control the home facilities. Finally, it is important to analyse and classify in depth the accuracy of context acquisition and the corresponding context control using cross-validation methods. A case study uses integrated mobile detection technology to improve the efficiency of mobile applications, taking into account the resource limitations forced on the use of mobile devices. It also utilises other embedded sensing technologies to predict expectations, thereby enabling automatic control of facilities in the home. The main approach is to combine search engines and machine learning to create a system architecture for a context-aware computing service. Among the major challenges are finding the best statistics-based rules for decision-making and overcoming the heterogeneous character of the many devices which are used together. The results achieved show very promising potential for the use of mobile applications within a context-aware computing service, albeit one which still presents problems to be resolved through future research