Advanced signal processing methods in dynamic contrast enhanced magnetic resonance imaging

Tato dizertační práce představuje metodu zobrazování perfúze magnetickou rezonancí, jež je výkonným nástrojem v diagnostice, především v onkologii. Po ukončení sběru časové sekvence T1-váhovaných obrazů zaznamenávajících distribuci kontrastní látky v těle začíná fáze zpracování dat, která je předmětem této dizertace. Je zde představen teoretický základ fyziologických modelů a modelů akvizice pomocí magnetické rezonance a celý řetězec potřebný k vytvoření obrazů odhadu parametrů perfúze a mikrocirkulace v tkáni. Tato dizertační práce je souborem uveřejněných prací autora přispívajícím k rozvoji metodologie perfúzního zobrazování a zmíněného potřebného teoretického rozboru.This dissertation describes quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), which is a powerful tool in diagnostics, mainly in oncology. After a time series of T1-weighted images recording contrast-agent distribution in the body has been acquired, data processing phase follows. It is presented step by step in this dissertation. The theoretical background in physiological and MRI-acquisition modeling is described together with the estimation process leading to parametric maps describing perfusion and microcirculation properties of the investigated tissue on a voxel-by-voxel basis. The dissertation is divided into this theoretical analysis and a set of publications representing particular contributions of the author to DCE-MRI.

Robust CS reconstruction based on appropriate minimization norm

Noise robust compressive sensing algorithm is considered. This algorithm allows an efficient signal reconstruction in the presence of different types of noise due to the possibility to change minimization norm. For instance, the commonly used l1 and l2 norms, provide good results in case of Laplace and Gaussian noise. However, when the signal is corrupted by Cauchy or Cubic Gaussian noise, these norms fail to provide accurate reconstruction. Therefore, in order to achieve accurate reconstruction, the application of l3 minimization norm is analyzed. The efficiency of algorithm will be demonstrated on examples

Molecular communication in fluid media: The additive inverse Gaussian noise channel

We consider molecular communication, with information conveyed in the time of release of molecules. The main contribution of this paper is the development of a theoretical foundation for such a communication system. Specifically, we develop the additive inverse Gaussian (IG) noise channel model: a channel in which the information is corrupted by noise with an inverse Gaussian distribution. We show that such a channel model is appropriate for molecular communication in fluid media - when propagation between transmitter and receiver is governed by Brownian motion and when there is positive drift from transmitter to receiver. Taking advantage of the available literature on the IG distribution, upper and lower bounds on channel capacity are developed, and a maximum likelihood receiver is derived. Theory and simulation results are presented which show that such a channel does not have a single quality measure analogous to signal-to-noise ratio in the AWGN channel. It is also shown that the use of multiple molecules leads to reduced error rate in a manner akin to diversity order in wireless communications. Finally, we discuss some open problems in molecular communications that arise from the IG system model.Comment: 28 pages, 8 figures. Submitted to IEEE Transactions on Information Theory. Corrects minor typos in the first versio

Estimation of the Degree of Polarization for Hybrid/Compact and Linear Dual-Pol SAR Intensity Images: Principles and Applications

Analysis and comparison of linear and hybrid/compact dual-polarization (dual-pol) synthetic aperture radar (SAR) imagery have gained a wholly new importance in the last few years, in particular, with the advent of new spaceborne SARs such as the Japanese ALOS PALSAR, the Canadian RADARSAT-2, and the German TerraSAR-X. Compact polarimetry, hybrid dual-pol, and quad-pol modes are newly promoted in the literature for future SAR missions. In this paper, we investigate and compare different hybrid/compact and linear dual-pol modes in terms of the estimation of the degree of polarization (DoP). The DoP has long been recognized as one of the most important parameters characterizing a partially polarized electromagnetic wave. It can be effectively used to characterize the information content of SAR data. We study and compare the information content of the intensity data provided by different hybrid/compact and linear dual-pol SAR modes. For this purpose, we derive the joint distribution of multilook SAR intensity images. We use this distribution to derive the maximum likelihood and moment-based estimators of the DoP in hybrid/compact and linear dual-pol modes.We evaluate and compare the performance of these estimators for different modes on both synthetic and real data, which are acquired by RADARSAT-2 spaceborne and NASA/JPL airborne SAR systems, over various terrain types such as urban, vegetation, and ocean

Studies in Signal Processing Techniques for Speech Enhancement: A comparative study

Speech enhancement is very essential to suppress the background noise and to increase speech intelligibility and reduce fatigue in hearing. There exist many simple speech enhancement algorithms like spectral subtraction to complex algorithms like Bayesian Magnitude estimators based on Minimum Mean Square Error (MMSE) and its variants. A continuous research is going and new algorithms are emerging to enhance speech signal recorded in the background of environment such as industries, vehicles and aircraft cockpit. In aviation industries speech enhancement plays a vital role to bring crucial information from pilot’s conversation in case of an incident or accident by suppressing engine and other cockpit instrument noises. In this work proposed is a new approach to speech enhancement making use harmonic wavelet transform and Bayesian estimators. The performance indicators, SNR and listening confirms to the fact that newly modified algorithms using harmonic wavelet transform indeed show better results than currently existing methods. Further, the Harmonic Wavelet Transform is computationally efficient and simple to implement due to its inbuilt decimation-interpolation operations compared to those of filter-bank approach to realize sub-bands

Laplace Approximation for Divisive Gaussian Processes for Nonstationary Regression

The standard Gaussian Process regression (GP) is usually formulated under stationary hypotheses: The noise power is considered constant throughout the input space and the covariance of the prior distribution is typically modeled as depending only on the difference between input samples. These assumptions can be too restrictive and unrealistic for many real-world problems. Although nonstationarity can be achieved using specific covariance functions, they require a prior knowledge of the kind of nonstationarity, not available for most applications. In this paper we propose to use the Laplace approximation to make inference in a divisive GP model to perform nonstationary regression, including heteroscedastic noise cases. The log-concavity of the likelihood ensures a unimodal posterior and makes that the Laplace approximation converges to a unique maximum. The characteristics of the likelihood also allow to obtain accurate posterior approximations when compared to the Expectation Propagation (EP) approximations and the asymptotically exact posterior provided by a Markov Chain Monte Carlo implementation with Elliptical Slice Sampling (ESS), but at a reduced computational load with respect to both, EP and ESS