110,014 research outputs found

    Bases moleculares de la interacción de la E3 ubiquitina ligasa TRIM7 con glucogenina-1 y su potencial relevancia en el contexto de la glucogenosis tipo XV

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    Tesis (Doctor en Ciencias Qu√≠micas) - - Universidad Nacional de C√≥rdoba. Facultad de Ciencias Qu√≠micas, 2021Resumen: La ubiquitinaci√≥n es un tipo de modificaci√≥n postraduccional caracter√≠stico de organismos eucariotas, que requiere de la acci√≥n conjunta de las enzimas E1 activadora, E2 conjugadora y E3 ligasa para mediar la transferencia de ubiquitina a una prote√≠na sustrato. TRIM7 es una E3 ligasa que recientemente ha adquirido inter√©s por su rol en diversas patolog√≠as, y pertenece a la familia de prote√≠nas TRIM, caracterizadas por un motivo conservado tripartito (TRIM) N-terminal y una regi√≥n C-terminal variable que puede mediar el reconocimiento de sustratos. Inicialmente, fue identificada como una prote√≠na que interacciona a trav√©s de su dominio C-terminal B30.2 (TRIM7B30.2) con glucogenina-1 (GN1). Dicha prote√≠na es responsable de la iniciaci√≥n de la bios√≠ntesis del gluc√≥geno, por lo que las mutaciones que afectan al gen que la codifica se traducen en un trastorno extremadamente raro denominado glucogenosis tipo XV. El presente trabajo se centr√≥ en caracterizar a TRIM7B30.2 por cristalograf√≠a de rayos X, y describir detalles sobre las regiones relevantes para la interacci√≥n con GN1. La estructura de TRIM7B30.2 revel√≥ un plegamiento de tipo s√°ndwich-ő≤ formado por dos l√°minas ő≤ antiparalelas caracter√≠stico de este tipo de dominios, adem√°s de presentar una cavidad con carga positiva en la cara c√≥ncava de dicho plegamiento. Adicionalmente, se logr√≥ identificar a residuos clave que delimitan la zona involucrada en la interacci√≥n con GN1, adem√°s de obtener indicios de que el extremo C-terminal de esta √ļltima es necesario para su reconocimiento por TRIM7B30.2 y la prote√≠na TRIM7 entera. Otra parte de este estudio se dedic√≥ a conocer el impacto de la mutaci√≥n patol√≥gica Ala16Pro sobre GN1 de conejo, que presenta una alta homolog√≠a con la prote√≠na humana, mediante el uso de un amplio conjunto de t√©cnicas bioqu√≠micas y biof√≠sicas. El an√°lisis revel√≥ un cambio estructural significativo que ocasion√≥ una disminuci√≥n de la afinidad por su sustrato y, en consecuencia, de la actividad de la prote√≠na; adem√°s de una marcada p√©rdida de estabilidad. Por √ļltimo, se busc√≥ conocer si GN1 y sus mutantes patol√≥gicas Ala16Pro y Thr83Met, son sustrato de su actividad E3 ligasa; y si esto podr√≠a tener un rol relevante en la glucogenosis tipo XV. Los resultados de la reacci√≥n in vitro mostraron que la transferencia de ubiquitina no ocurre bajo las condiciones empleadas, sin embargo, se encontr√≥ que TRIM7 interacciona con la mutante patol√≥gica GN1 Ala16Pro pese al cambio estructural de la prote√≠na, lo que podr√≠a implicar a TRIM7 en la v√≠a de degradaci√≥n de esta mutante, y por ello el estudio ser√° continuado en cultivos celulares.Abstract : Ubiquitination is a common post translational modification in eukaryotes, which involves an E1 activating enzyme, an E2 conjugating enzyme, and an E3 ligase enzyme; in a process that mediates the transfer of ubiquitin to a substrate protein. TRIM7 is an E3 ligase member of the TRIM protein family, characterized by an N-terminal tripartite motif (TRIM) and a variable C-terminal region that can mediate substrate recognition, that has been recently linked to diverse pathological processes. TRIM7 was initially identified as a glycogenin-1 (GN1) interacting protein, and this interaction involves the C-terminal B30.2 domain of TRIM7 (TRIM7B30.2). GN1 is the protein that initiates glycogen biosynthesis, and mutations in the gene that encodes for this enzyme are involved in the onset of an extremely rare disease known as type XV glycogen storage disease. This work was mainly focused on the characterization of TRIM7B30.2, through the use of X-ray crystallography, and the details of the region involved in the interaction with GN1. The structure of TRIM7B30.2 revealed the characteristic B30.2 domain fold consisting of two ő≤-sheets arranged as a distorted ő≤-sandwich, and a positively charged cavity in the hypervariable region of this domain. Besides, key residues that define the zone of interaction with GN1 were identified, and evidence for the requirement of the latter‚Äôs C-terminal region in the binding was found. This study was also focused on the effect of the pathogenic Ala16Pro mutation on rabbit GN1, which displays a high sequence homology with the human protein; and to this end, a wide range of biophysical and biochemical techniques were applied. The analysis revealed a significant structural change which resulted in a decrease in substrate affinity and protein activity, besides a considerable loss of stability. Finally, the thesis was oriented towards analyzing the potential E3 ligase activity of TRIM7 on GN1 and the pathological mutants Ala16Pro and Thr83Met, and its possible functional role on type XV glycogen storage disease. The results have shown that in vitro, TRIM7 does not transfer ubiquitin to GN1 or the mutants in this experimental setup. However, it was found that despite the structural change caused by the mutation, TRIM7 still interacts with the Ala16Pro mutant of human GN1, which might implicate the intervention of TRIM7 in the degradation pathway of this mutant, and for this reason, this study will be continued in cell cultures.2023-08-30Fil: Mu√Īoz Sosa, Christian Javier. Universidad Nacional de C√≥rdoba. Facultad de Ciencias Qu√≠micas; Argentina.Fil: Carrizo Garcia, Mar√≠a Elena. Universidad Nacional de C√≥rdoba. Facultad de Ciencias Qu√≠micas. Departamento de Qu√≠mica Biol√≥gica; Argentina.Fil: Carrizo Garcia, Mar√≠a Elena. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro de Investigaciones en Qu√≠mica Biol√≥gica de C√≥rdoba; Argentina.Fil: Genti de Raimondi, Susana Del Valle. Universidad Nacional de C√≥rdoba. Facultad de Ciencias Qu√≠micas. Departamento de Bioqu√≠mica Cl√≠nica; Argentina.Fil: Genti de Raimondi, Susana del Valle. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro de Investigaciones en Bioqu√≠mica Cl√≠nica e Inmunolog√≠a; Argentina.Fil: Carbonio, Raul Ernesto. Universidad Nacional de C√≥rdoba. Facultad de Ciencias Qu√≠micas. Departamento de Fisicoqu√≠mica; Argentina.Fil: Carbonio, Raul Ernesto. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Instituto de Investigaciones en Fisicoqu√≠mica de C√≥rdoba; Argentina.Fil: Romero, Jorge Miguel. Universidad Nacional de C√≥rdoba. Facultad de Ciencias Qu√≠micas; Argentina.Fil: Erm√°cora, Mario Roberto. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Instituto Multidisciplinario de Biolog√≠a Celular; Argentina

    Sponsorship image and value creation in E-sports

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    .E-sports games can drive the sports industry forward and sponsorship is the best way to engage consumers of this new sport. The purpose of this study is to examine the effect of sponsorship image and consumer participation in co-creation consumption activities on fans’ sponsorship response (represented by the variables interest, purchase intention and word of mouth) in e-sports. Four antecedent variables build sponsorship image (i.e., ubiquity of sport, sincerity of sponsor, attitude to sponsor and team identification). A quantitative approach is used for the purposes of this study. Some 445 questionnaires were filled in by fans who watch e-sports in Spain; these are analyzed using partial least squares structural equation modeling (PLS-SEM). The outcomes show that sponsor antecedents are crucial factors if a sponsor wants to change their sponsorship image and influence sponsorship response, and that it is also possible to use participation to improve responsesS

    Relaciones sociales y creatividad en la empresa: la importancia de la calidad de las interacciones del empleado con su entorno m√°s cercano

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    pp. 1-16La creatividad se está convirtiendo en un fenómeno de especial importancia para las organizaciones. Por ello, existe un interés creciente por comprender cuáles son los factores responsables del rendimiento creativo en los entornos laborales. A pesar de ello, todavía existen lagunas importantes en la literatura sobre la influencia del liderazgo y del comportamiento de los grupos en la creatividad. Con el fin de aportar nueva evidencia empírica al respecto, el objetivo del presente trabajo consiste en analizar cómo influyen las relaciones de intercambio que mantiene el empleado con su superior inmediato y con su grupo de trabajo en la creatividad que pone de manifiesto.S

    Balancing the urban stomach: public health, food selling and consumption in London, c. 1558-1640

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    Until recently, public health histories have been predominantly shaped by medical and scientific perspectives, to the neglect of their wider social, economic and political contexts. These medically-minded studies have tended to present broad, sweeping narratives of health policy's explicit successes or failures, often focusing on extraordinary periods of epidemic disease viewed from a national context. This approach is problematic, particularly in studies of public health practice prior to 1800. Before the rise of modern scientific medicine, public health policies were more often influenced by shared social, cultural, economic and religious values which favoured maintaining hierarchy, stability and concern for 'the common good'. These values have frequently been overlooked by modern researchers. This has yielded pessimistic assessments of contemporary sanitation, implying that local authorities did not care about or prioritise the health of populations. Overly medicalised perspectives have further restricted historians' investigation and use of source material, their interpretation of multifaceted and sometimes contested cultural practices such as fasting, and their examination of habitual - and not just extraordinary - health actions. These perspectives have encouraged a focus on reactive - rather than preventative - measures. This thesis contributes to a growing body of research that expands our restrictive understandings of pre-modern public health. It focuses on how public health practices were regulated, monitored and expanded in later Tudor and early Stuart London, with a particular focus on consumption and food-selling. Acknowledging the fundamental public health value of maintaining urban foodways, it investigates how contemporaries sought to manage consumption, food production waste, and vending practices in the early modern City's wards and parishes. It delineates the practical and political distinctions between food and medicine, broadly investigates the activities, reputations of and correlations between London's guild and itinerant food vendors and licensed and irregular medical practitioners, traces the directions in which different kinds of public health policy filtered up or down, and explores how policies were enacted at a national and local level. Finally, it compares and contrasts habitual and extraordinary public health regulations, with a particular focus on how perceptions of and actual food shortages, paired with the omnipresent threat of disease, impacted broader aspects of civic life

    Tense times for young migrants: temporality, life-course and immigration status

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    This article explores the intersection between immigration status, life-course and the experience of time. It looks at how time and life-course transitions are experienced by young people who are in constant encounter with the immigration regime in the UK. The encounters at this intersection produce a complex landscape for young people to navigate during their transitions to adulthood. What emerges from unpicking the relations of this messy and complex temporal-immigration status matrix, are distinct experiences of time and life-course transitions for young migrants. First, in dealing with the immigration regime young people are confined to a passive role of waiting that results in a sense of feeling stuck. Secondly, pre-18 young people experience a growing up too early and upon turning 18 and gaining legal independence, their situation paradoxically leads to practical dependence. And thirdly, the immigration status renewal system produces long-term uncertainty for young people’s futures

    The Time Devil runs amok: How I improved my creative practice by adopting a multimodal approach for a specific audience.

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    This research illustrates how teacher-writers can improve their craft and pedagogy by writing for a specific audience, namely school children. It also illustrates why they might do so. It interrogates what was learnt from an innovative collaboration between a university teacher-education department, an inner-city secondary school and the United Kingdom‚Äôs National Maritime Museum (NMM). Multimodality (Barnard 2019) inspired the project: local spaces, institutional settings, historical objects, photographs, pictures, time-travelling films and narratives motivated the teacher-writer and participants to read and respond imaginatively to the world. The author found that the project caused him to ‚Äúremediate‚ÄĚ his own practice: to transfer ‚Äúexisting skills in order to tackle new genres‚ÄĚ (Barnard 2019: 121). This process enabled him to become a more effective writer and teacher. The research shows that the problem of multimodal overload ‚Äď having too much choice regarding what to write about and the many forms writing can take ‚Äď can be circumnavigated if participants are given both autonomy and constraints. It illustrates in some depth how the concept of reciprocity is vital to adopt if writers are to improve their craft

    Uso de las histonas circulantes y sus modificaciones post-traduccionales como biomarcadores en sepsis y shock séptico

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    La sepsis es una afecci√≥n potencialmente mortal causada por una respuesta anormal del hu√©sped a una infecci√≥n, produciendo respuestas fisiol√≥gicas alteradas que da√Īan los propios tejidos del paciente y pueden provocar disfunci√≥n org√°nica e incluso la muerte. Asimismo, algunos pacientes s√©pticos progresan a shock s√©ptico, caracterizado por alteraciones circulatorias, celulares y metab√≥licas sustanciales que aumentan el riesgo de mortalidad. A pesar de que la sepsis se caracteriza por un mal funcionamiento del sistema inmunol√≥gico, lo que a su vez conduce a una respuesta inmune alterada e inmunosupresi√≥n, la alta complejidad de la fisiopatolog√≠a de la sepsis requiere una mayor investigaci√≥n para comprender las respuestas inmunes que ocurren durante la sepsis. Asimismo, las histonas extracelulares circulantes han ganado relevancia como mediadores citot√≥xicos en la sepsis, ya que act√ļan como patrones moleculares asociados a da√Īo, que inducen estr√©s oxidativo y activan el inflamasoma NLRP3. Estos mecanismos median la activaci√≥n de la piroptosis, un mecanismo de muerte celular programada que produce inflamaci√≥n mediante la expresi√≥n de IL-18, IL-1ő≤ and IL-1őĪ. Sin embargo, a pesar de la evidencia de activaci√≥n del inflamasoma en las c√©lulas inmunes durante la sepsis, se desconoce si las histonas extracelulares son capaces de activar los inflamasomas endoteliales y sus consecuencias. En este trabajo destacamos el papel previamente desconocido de las histonas extracelulares, mediando la activaci√≥n del inflamasoma NLRP3 y la piroptosis en las c√©lulas endoteliales, contribuyendo a la disfunci√≥n endotelial y la desregulaci√≥n de la respuesta inmune mediada por el endotelio. Asimismo, tambi√©n demostramos c√≥mo la acetilaci√≥n de histonas disminuye la activaci√≥n de la piroptosis. Adem√°s, demostramos que la piroptosis se produce en pacientes con shock s√©ptico y los niveles de histonas circulantes se correlacionan con la expresi√≥n de citoquinas proinflamatorias y citoquinas piropt√≥ticas, la liberaci√≥n de factores de adhesi√≥n endotelial y la gravedad de la enfermedad. Proponemos la piroptosis mediada por histonas como un nuevo objetivo para desarrollar intervenciones cl√≠nicas. De manera similar, hemos analizado las respuestas inmunorelacionadas que ocurren durante las primeras etapas de la sepsis con el objetivo de proporcionar nuevos datos comparando las cantidades de citoquinas, inmunomoduladores y otros mediadores endoteliales en pacientes cr√≠ticamente enfermos no s√©pticos, s√©pticos y de shock s√©ptico. Nuestro enfoque ayudar√° a caracterizar r√°pidamente las respuestas inmunes alteradas en pacientes s√©pticos y de shock s√©ptico ingresados en la Unidad de Cuidados Intensivos. Finalmente analizamos el papel de la metilaci√≥n del ADN en el control del sistema inmune s√©ptico. Nuestros resultados demostraron el papel central de la metilaci√≥n del ADN modulando la respuesta molecular en los pacientes de shock s√©ptico y contribuyendo a la inmunosupresi√≥n, a trav√©s de la alteraci√≥n de los patrones de metilaci√≥n de los promotores de IL-10 y TREM-2.Sepsis is a life-threatening condition caused by an abnormal host response to an infection that produce altered physiological responses which damages own tissues of the patient and can result in organ dysfunction and in some cases death. Likewise, a subset of septic patients progresses to septic shock, characterized by substantial circulatory, cellular and metabolic abnormalities, which substantially increase the risk of mortality. Sepsis is characterized by a malfunction of the immune system and it can lead to an altered immune response and immunosuppression. Moreover, the high complexity of the pathophysiology of sepsis requires of further investigation to characterize the immune responses in sepsis and septic shock. Likewise, circulating extracellular histones have gained relevance as cytotoxic mediators in sepsis pathophysiology, since they act as damage-associated molecular patterns, which induce oxidative stress and activate NLRP3 inflammasome. Subsequently, inflammasome mediates pyroptosis activation, a programmed cell death mechanism that produces inflammation through the release of IL-18, IL-1ő≤ and IL-1őĪ. However, despite inflammasome activation may occur in immune cells during sepsis, it is unknown if this process also takes place in endothelial cells and particularly whether extracellular histones are capable of activating endothelial inflammasomes and their consequences. In this work we highlight a previously unknown role for extracellular histones, that mediates the activation of NLRP3 inflammasome and pyroptosis in endothelial cells by contributing to endothelial dysfunction and the dysregulation of the immune response mediated by endothelium. Likewise, we demonstrated how histone acetylation decreases pyroptosis activation. Furthermore, we show how pyroptosis occurs in septic shock patients and how circulating histone levels correlate with the expression of pro-inflammatory and pyroptotic cytokines, the release of endothelial adhesion factors and septic shock severity. We propose histone-mediated pyroptosis as a new target to develop clinical interventions. Similarly, we have analyzed the immune-related responses occurring during the early stages of sepsis with the aim of providing new data by comparing the amounts of cytokines, immune modulators and other endothelial mediators in critically-ill non-septic patients, septic and septic shock patients. Our approach will help to rapidly characterize the altered immune responses in septic and septic shock patients admitted in the Intensive Care Unit. Finally, we also analyzed the role of DNA methylation in the control of septic immune system. Our results demonstrated the central role of DNA methylation modulating the molecular response in septic shock patients and contributing to immunosuppression, through the alteration of DNA methylation patterns of IL-10 and TREM2 promoters

    Metodología de intervención para trabajar ODS. Educación a través de las artes

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    La Agenda 2030 presenta 17 Objetivos de Desarrollo Sostenible (ODS), con sus metas e indicadores universales que los pa√≠ses miembros de la ONU emplean para enmarcar sus pol√≠ticas. Entre las metas del ODS 4 ‚Äúeducaci√≥n de calidad‚ÄĚ encontramos: ‚Äúasegurar que todos los alumnos adquieran los conocimientos te√≥ricos y pr√°cticos necesarios para promover el desarrollo sostenible, entre otras cosas mediante la educaci√≥n para el desarrollo sostenible y los estilos de vida sostenibles, los derechos humanos, la igualdad de g√©nero, la promoci√≥n de una cultura de paz y no violencia, la ciudadan√≠a mundial y la valoraci√≥n de la diversidad cultural y la contribuci√≥n de la cultura al desarrollo sostenible‚ÄĚ. La educaci√≥n, se considera el motor de la Agenda 2030 porque, adem√°s de representar el centro del ODS 4, desempe√Īa tambi√©n un papel notable en la implementaci√≥n de los dem√°s, mejorando su alcance y efectividad. As√≠ pues, entre las disciplinas que sustentan este trabajo se escogi√≥ la Educaci√≥n para el Desarrollo Sostenible y la Ciudadan√≠a Global como marco de acci√≥n y punto de partida en la formaci√≥n de los ciudadanos de un futuro viable, equitativo y habitable. Se continu√≥ investigando las oportunidades del desarrollo de la Competencia Intercultural en las relaciones humanas, aquello que diferencia a unas personas de otras puede aportar al conjunto de la sociedad y c√≥mo la educaci√≥n permitir√≠a su aprovechamiento. Con todo ello, se plante√≥ el marco did√°ctico de interacci√≥n en el cual se implement√≥ la interculturalidad en el ejercicio educativo. Se estudi√≥ as√≠ el poder de las artes como medio de motivaci√≥n e inspiraci√≥n a la hora de transmitir de la manera m√°s eficaz posible los valores considerados m√°s arriba. El objetivo del presente estudio se centra en demostrar el potencial de las artes para fomentar las competencias comunicativas, sociales, interculturales, emocionales, de ciudadan√≠a y sostenibilidad. Para ello, se ha realizado una investigaci√≥n aplicada que deriva en una propuesta concreta de intervenci√≥n con un programa educativo destinado a la ense√Īanza de lenguas, tanto primera como extranjera, en distintos niveles de la educaci√≥n formal en Mali y en Espa√Īa, aplicando un m√©todo hol√≠stico basado en el paradigma interpretativo. A trav√©s de la pintura, la literatura y el cine, se plantean una serie de actividades ideadas para crear un entorno educativo integrador, favorecer el empoderamiento del alumnado y promover el pensamiento cr√≠tico, la empat√≠a, la resiliencia, la comunicaci√≥n, la cooperaci√≥n y la educaci√≥n intercultural, como competencias esenciales para la consecuci√≥n de los 17 ODS, la construcci√≥n de un mundo transcultural sostenible y el desarrollo de una ciudadan√≠a global preparada para los retos del siglo XXI. En la metodolog√≠a de este proceso educativo innovador, multidisciplinar, flexible y adaptable, se ha empleado un an√°lisis del proceso de investigaci√≥n para monitorizarlo adecuadamente (DAFO). Cada una de las propuestas presenta una recogida de datos cualitativos (observaci√≥n, r√ļbricas) y cuantitativos (encuestas, entrevistas) y se ofrece un an√°lisis de contraste de los resultados finales. Con todo, se espera facilitar la exigente tarea que supone hacer consciente a la sociedad de base (desde la misma infancia; desde los niveles m√°s bajos de la misma y en todos los niveles de la educaci√≥n formal) de en qu√© consisten los ODS y su relevancia para hacer de todas las personas corresponsables directas en su consecuci√≥n para garantizar un futuro sostenible para toda la ciudadan√≠a global.The 2030 Agenda presents 17 Sustainable Development Goals (SDGs), with their universal targets and indicators that UN member countries use to frame their policies. Among the targets of SDG 4 ‚Äúquality education,‚ÄĚ we find the one that seeks: ‚Äúto ensure that all students acquire the theoretical and practical knowledge necessary to promote sustainable development, among other things through education for sustainable development and sustainable lifestyles, human rights, gender equality, the promotion of a culture of peace and non-violence, world citizenship and the appreciation of cultural diversity and the contribution of culture to sustainable development‚ÄĚ. Education is considered the engine of the 2030 Agenda because, in addition to representing the centre of SDG 4, it also plays a notable role in the implementation of the others, improving their scope and effectiveness. Among the disciplines that support this research, Education for Sustainable Development and Global Citizenship sets the framework for action and represents a starting point in the formation of citizens for a viable, equitable and habitable future. Global citizenship implies human relations and those and intrinsically shaped by culture. Intercultural Education and, more specifically, the development of Intercultural Competence needed to be considered. What differentiates some people from others can contribute to society as a whole and education is the means to explore and understand. For the design of a didactic framework of interaction, the power of the arts was studied as a means of motivation and inspiration when transmitting the values considered above in the most effective way possible. The objective of this study focuses on proving the potential of the arts to promote communicative, social, intercultural, emotional, citizenship and sustainability skills. For this, the theoretical research derived in a concrete intervention proposal with an educational program in language teaching, both first and foreign languages, at different levels of formal education in Mali and Spain, applying a holistic method based on the interpretive paradigm. Through painting, literature and cinema, a series of activities were designed to create an inclusive educational environment, favour the empowerment of students and promote critical thinking, empathy, resilience, communication, cooperation and intercultural education, as essential skills for the achievement of the 17 SDGs, the construction of a sustainable transcultural world and the development of global citizenship prepared for the challenges of the 21st century. In the methodology of this innovative, multidisciplinary, flexible and adaptable educational process, an analysis of the research process has been used to adequately monitor it (SWOT). Each of the proposals presents a collection of qualitative data (observation, rubrics) and quantitative data (surveys, interviews) and contrast analysis of the final results is offered. All in all, it is expected to facilitate the demanding task of making basic society aware (from childhood itself, from its lowest levels and at all levels of formal education) of what the SDGs consist of and their relevance to make all people directly co-responsible in its achievement to guarantee a sustainable future for all global citizens

    Dynamic and Static Cognitive Deficits in Schizophrenia and Bipolar Disorder After the First Episode

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    Abstract Few studies have comprehensively examined the profile of cognitive functioning in first episode psychosis patients throughout the lifespan, and from first episode to chronic stage. We assessed functioning in general and specific cognitive functions, comparing both schizophrenia (N = 64) and bipolar I (N = 19) patients to controls (N = 103). Participants were from a population-based, case-control study of first episode psychosis patients, who were followed prospectively up to 10 years post first admission. A cognitive battery was administered at baseline and follow-up. By combining longitudinal and cross-sectional data, we were able to examine the cognitive profile of patients and controls throughout the entire age range of our sample (16‚Äď65). Schizophrenia patients exhibited widespread declines in IQ, executive function, visual memory, language ability, and verbal knowledge. However, the ages at which these declines occurred differed between functions. Deficits in verbal memory, working memory, processing speed, and visuospatial ability, on the other hand, were present at the first episode, and remained relatively static thereafter. Bipolar I patients also showed declines in IQ, verbal knowledge, and language ability, albeit at different ages to schizophrenia patients and only in verbal functions. Deficits on measures of verbal memory, processing speed, and executive function remained relatively static. Thus, both schizophrenia and bipolar I patients experienced cognitive decline in general and specific functions after the first episode, but the age at which these declines occurred differed between disorder and function. Cognitive remediation efforts may be most fruitful when targeting individual functions during specific time periods throughout adulthood

    Proyecto Documental Ausencias

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    Ausencias es un proyecto documental que aborda tem√°ticas en torno a la p√©rdida, la muerte desconocida, el perd√≥n, la separaci√≥n y la ausencia de seres queridos. El documental se divide en cuatro historias de personas allegadas a las integrantes del grupo, quienes narran desde su perspectiva la manera en c√≥mo han llevado su proceso de duelo y/o ausencia de un familiar y las consecuencias que este conlleva. En el presente informe se explicar√° a mayor detalle el proceso de realizaci√≥n de este proyecto, el cual inici√≥ a partir de entrevistas con nuestros protagonistas y la exploraci√≥n sensorial de nuestro entorno para posteriormente lograr la construcci√≥n de voz en off y textos narrativos, acompa√Īados de material de archivo y registros visuales que complementen la atm√≥sfera generada por el relato. El objetivo principal del proyecto es poder expresar la sucesi√≥n de pensamientos y estados an√≠micos que se presentan luego de la ausencia de un ser del entorno y c√≥mo √©sta pueda repercutir en la vida de los protagonistas y su familia.Ausencias is a documentary project that addresses issues around loss, unknown death, forgiveness, separation and the absence of loved ones. The documentary is divided into four stories of people close to the members of the group, who narrate from their perspective the way in which they have handled their grieving process and / or absence of a family member and the consequences that this entails. In this report, the process of carrying out this project will be explained in greater detail, which began from interviews with our protagonists and the sensory exploration of our environment to later achieve the construction of voice-over and narrative texts, accompanied by archive footage and visual records that complement the atmosphere generated by the story. The main objective of the project is to be able to express the succession of thoughts and moods that appear after the absence of a being from the environment and how this can affect the lives of the protagonists and their families.Trabajo de investigaci√≥
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