On Communication-Efficient Multisensor Track Association via Measurement Transformation (Extended Version)

Multisensor track-to-track fusion for target tracking involves two primary operations: track association and estimation fusion. For estimation fusion, lossless measurement transformation of sensor measurements has been proposed for single target tracking. In this paper, we investigate track association which is a fundamental and important problem for multitarget tracking. First, since the optimal track association problem is a multi-dimensional assignment (MDA) problem, we demonstrate that MDA-based data association (with and without prior track information) using linear transformations of track measurements is lossless, and is equivalent to that using raw track measurements. Second, recent superior scalability and performance of belief propagation (BP) algorithms enable new real-time applications of multitarget tracking with resource-limited devices. Thus, we present a BP-based multisensor track association method with transformed measurements and show that it is equivalent to that with raw measurements. Third, considering communication constraints, it is more beneficial for local sensors to send in compressed data. Two analytical lossless transformations for track association are provided, and it is shown that their communication requirements from each sensor to the fusion center are less than those of fusion with raw track measurements. Numerical examples for tracking an unknown number of targets verify that track association with transformed track measurements has the same performance as that with raw measurements and requires fewer communication bandwidths

MAC layer assisted localization in wireless environments with multiple sensors and multiple emitters

Extreme emitter density (EED) RF environments, defined as 10k-100k emitters within a footprint of less than 1 km squared, are becoming increasingly common with the proliferation of personal devices containing myriad communication standards (e.g. WLAN, Bluetooth, 4G, etc). Attendees at concerts, sporting events, and other such large-scale events desire to be connected at all times, creating tremendous spectrum management challenges, especially in unlicensed frequencies such as 2.4 GHz, 5 GHz, or 900 MHz Industrial, Scientific, and Medical (ISM) bands. In licensed bands, there are often critical communication systems such as two-way radios for emergency personnel which must be free from interference. Identification and localization of a non-conforming or interfering Emitter of Interest (EoI) is important for these critical systems. In this dissertation, research is conducted to improve localization for these EED RF environments by exploiting side information available at the Medium Access Control (MAC) layer. The primary contributions of this research are: (1) A testbed in Bobby Dodd football stadium consisting of three spatially distributed, time-synchronized RF Sensor Nodes (RFSN) collecting and archiving complex baseband samples for algorithm development and validation. (2) A modeling framework and analytical results on the benefits of exploiting the structure of the MAC layer for associating physical layer measurements, such as Time Difference of Arrivals (TDoA), to emitters. (3) A three stage localization algorithm exploiting time between packets and a constrained geometry to shrink the error ellipse of the emitter position estimate. The results are expected to improve localization accuracy in wireless environments when multiple sensors observe multiple emitters using a known communications protocol within a constrained geometry.Ph.D

Enhancing Sensor Performance with Statistical Data Analytics

This thesis examines the use of Automatic Identification System (AIS) information to generate a picture of maritime activity. It derives suitable methods to produce tracks of vessel movements, both in littoral and open-ocean scenarios, removing ambiguities and highlighting doppelg�anger. The thesis then goes on to describe techniques to improve our understanding of maritime activities through the extraction of individual vessel behaviours and the generation of models describing normal behaviours to highlight abnormalities

Debating Space Security: Capabilities and Vulnerabilities

The U.S. position in the debate on space security has been that (1) space-based systems could be developed and used to obtain decisive warghting superiority over an adversary, and (2) these space-based systems, because they might give such an inordinate advantage over any adversary, will be attacked. The Russians and Chinese, in contrast, claim to be threatened by U.S. aspirations in space but deny that they pose a serious threat to U.S. space-based systems. They view the development of advanced military space systems by the United States as evidence of a growing gap of military capabilities limited only by technological--not political--constraints. They argue that U.S. missile defense systems operating in coordination with advanced satellite sensors would weaken their nuclear retaliatory potential. This dissertation argues that the positions held by both of these parties are more extreme than warranted. An analytical evaluation quickly narrows the touted capabilities and assumed vulnerabilities of space systems to a much smaller set of concerns that can be addressed by collaboration. Chapter 2: Operationally Responsive Space (ORS): Is 24/7 Warghter Support Feasible? demonstrates the infeasibility of dramatically increasing U.S. warfighting superiority by using satellites. Chapter 3: What Can be Achieved by Attacking Satellites? makes the case that although U.S. armed forces rely extensively on its satellite infrastructure, that does not immediately make them desirable targets. The functions performed by military satellites are diffused among large constellations with redundancies. Also, some of the functions performed by these satellites can be substituted for by other terrestrial and aerial systems. Chapter 4: The Limits of Chinese Anti-Satellite Missiles demonstrates that anti-satellite (ASAT) intercepts are very complex under realistic conditions and that a potential adversary with space capabilities comparable to China's has very limited capability to use ASATs in a real-world battle scenario. Finally, in order to evaluate the chief concern raised by the Russians and Chinese, chapter 5: Satellites, Missile Defense and Space Security simulates a boost-phase missile defense system cued by the advanced Space Tracking and Surveillance (STSS) sensors. It demonstrates that even under best case assumptions, the STSS sensors are not good enough for the boost-phase missile defense system to successfully intercept and destroy an ICBM. Together, these chapters aim to narrow the contentions in the debate on space security thereby fostering the international colloboration and data sharing needed to ensure safe operations in space

Advances in PET Detection of the Antitumor T Cell Response

Positron emission tomography (PET) is a powerful noninvasive imaging technique able to measure distinct biological processes in vivo by administration of a radiolabeled probe. Whole-body measurements track the probe accumulation providing a means to measure biological changes such as metabolism, cell location, or tumor burden. PET can also be applied to both preclinical and clinical studies providing three-dimensional information. For immunotherapies (in particular understanding T cell responses), PET can be utilized for spatial and longitudinal tracking of T lymphocytes. Although PET has been utilized clinically for over 30 years, the recent development of additional PET radiotracers have dramatically expanded the use of PET to detect endogenous or adoptively transferred T cells in vivo. Novel probes have identified changes in T cell quantity, location, and function. This has enabled investigators to track T cells outside of the circulation and in hematopoietic organs such as spleen, lymph nodes, and bone marrow, or within tumors. In this review, we cover advances in PET detection of the antitumor T cell response and areas of focus for future studies

IN SILICO METHODS FOR DRUG DESIGN AND DISCOVERY

Computer-aided drug design (CADD) methodologies are playing an ever-increasing role in drug discovery that are critical in the cost-effective identification of promising drug candidates. These computational methods are relevant in limiting the use of animal models in pharmacological research, for aiding the rational design of novel and safe drug candidates, and for repositioning marketed drugs, supporting medicinal chemists and pharmacologists during the drug discovery trajectory.Within this field of research, we launched a Research Topic in Frontiers in Chemistry in March 2019 entitled “In silico Methods for Drug Design and Discovery,” which involved two sections of the journal: Medicinal and Pharmaceutical Chemistry and Theoretical and Computational Chemistry. For the reasons mentioned, this Research Topic attracted the attention of scientists and received a large number of submitted manuscripts. Among them 27 Original Research articles, five Review articles, and two Perspective articles have been published within the Research Topic. The Original Research articles cover most of the topics in CADD, reporting advanced in silico methods in drug discovery, while the Review articles offer a point of view of some computer-driven techniques applied to drug research. Finally, the Perspective articles provide a vision of specific computational approaches with an outlook in the modern era of CADD

Counter Unmanned Aircraft Systems Technologies and Operations

As the quarter-century mark in the 21st Century nears, new aviation-related equipment has come to the forefront, both to help us and to haunt us. (Coutu, 2020) This is particularly the case with unmanned aerial vehicles (UAVs). These vehicles have grown in popularity and accessible to everyone. Of different shapes and sizes, they are widely available for purchase at relatively low prices. They have moved from the backyard recreation status to important tools for the military, intelligence agencies, and corporate organizations. New practical applications such as military equipment and weaponry are announced on a regular basis – globally. (Coutu, 2020) Every country seems to be announcing steps forward in this bludgeoning field. In our successful 2nd edition of Unmanned Aircraft Systems in the Cyber Domain: Protecting USA’s Advanced Air Assets (Nichols, et al., 2019), the authors addressed three factors influencing UAS phenomena. First, unmanned aircraft technology has seen an economic explosion in production, sales, testing, specialized designs, and friendly / hostile usages of deployed UAS / UAVs / Drones. There is a huge global growing market and entrepreneurs know it. Second, hostile use of UAS is on the forefront of DoD defense and offensive planners. They are especially concerned with SWARM behavior. Movies like “Angel has Fallen,” where drones in a SWARM use facial recognition technology to kill USSS agents protecting POTUS, have built the lore of UAS and brought the problem forefront to DHS. Third, UAS technology was exploding. UAS and Counter- UAS developments in navigation, weapons, surveillance, data transfer, fuel cells, stealth, weight distribution, tactics, GPS / GNSS elements, SCADA protections, privacy invasions, terrorist uses, specialized software, and security protocols has exploded. (Nichols, et al., 2019) Our team has followed / tracked joint ventures between military and corporate entities and specialized labs to build UAS countermeasures. As authors, we felt compelled to address at least the edge of some of the new C-UAS developments. It was clear that we would be lucky if we could cover a few of – the more interesting and priority technology updates – all in the UNCLASSIFIED and OPEN sphere. Counter Unmanned Aircraft Systems: Technologies and Operations is the companion textbook to our 2nd edition. The civilian market is interesting and entrepreneurial, but the military and intelligence markets are of concern because the US does NOT lead the pack in C-UAS technologies. China does. China continues to execute its UAS proliferation along the New Silk Road Sea / Land routes (NSRL). It has maintained a 7% growth in military spending each year to support its buildup. (Nichols, et al., 2019) [Chapter 21]. They continue to innovate and have recently improved a solution for UAS flight endurance issues with the development of advanced hydrogen fuel cell. (Nichols, et al., 2019) Reed and Trubetskoy presented a terrifying map of countries in the Middle East with armed drones and their manufacturing origin. Guess who? China. (A.B. Tabriski & Justin, 2018, December) Our C-UAS textbook has as its primary mission to educate and train resources who will enter the UAS / C-UAS field and trust it will act as a call to arms for military and DHS planners.https://newprairiepress.org/ebooks/1031/thumbnail.jp

COMPUTATIONAL ANALYSIS OF CODE-MULTIPLEXED COULTER SENSOR SIGNALS

Nowadays, lab-on-a-chip (LoC) technology has been applied in a variety of applications because of its capability to perform accurate microscale manipulations of cells for point-of-care diagnostics. On the other hand, such a result is not readily available from an LoC device and typically still requires a post-inspection of the chip using traditional laboratory equipment such as a microscope, negating the advantages of the LoC technology. To solve this dilemma, my doctoral research mainly focuses on developing portable and disposable biosensors for interfacing with and digitizing the information from an LoC system. Our sensor platform, integrated with multiple microfluidic impedance sensors, electrically monitors and tracks manipulated cells on an LoC device. The sensor platform compresses information from each sensor into a 1-dimensional electrical waveform, and therefore, further signal processing is required to recover the readout of each sensor and extract information of detected cells. Furthermore, with the capability of the sensor platform, we have introduced integrated microfluidic cytometers to characterize properties of cells such as cell surface expression and mechanical properties.Ph.D

Advanced Strategies for Robot Manipulators

Amongst the robotic systems, robot manipulators have proven themselves to be of increasing importance and are widely adopted to substitute for human in repetitive and/or hazardous tasks. Modern manipulators are designed complicatedly and need to do more precise, crucial and critical tasks. So, the simple traditional control methods cannot be efficient, and advanced control strategies with considering special constraints are needed to establish. In spite of the fact that groundbreaking researches have been carried out in this realm until now, there are still many novel aspects which have to be explored

Aeronautical engineering: A continuing bibliography with indexes (supplement 296)

This bibliography lists 592 reports, articles, and other documents introduced into the NASA scientific and technical information system in Oct. 1993. Subject coverage includes: design, construction and testing of aircraft and aircraft engines; aircraft components, equipment, and systems; ground support systems; and theoretical and applied aspects of aerodynamics and general fluid dynamics