1,200 research outputs found
Dynamics of epidemic diseases on a growing adaptive network
The study of epidemics on static networks has revealed important effects on disease prevalence of network topological features such as the variance of the degree distribution, i.e. the distribution of the number of neighbors of nodes, and the maximum degree. Here, we analyze an adaptive network where the degree distribution is not independent of epidemics but is shaped through disease-induced dynamics and mortality in a complex interplay. We study the dynamics of a network that grows according to a preferential attachment rule, while nodes are simultaneously removed from the network due to disease-induced mortality. We investigate the prevalence of the disease using individual-based simulations and a heterogeneous node approximation. Our results suggest that in this system in the thermodynamic limit no epidemic thresholds exist, while the interplay between network growth and epidemic spreading leads to exponential networks for any finite rate of infectiousness when the disease persists
Mathematical Approaches to Infectious Disease Prediction and Control
Mathematics has long been an important tool for understanding and controlling the spread of infectious diseases. Here, we begin with an overview of compartmental models, the traditional approach to modeling infectious disease dynamics, and then introduce contact network epidemi- ology, a relatively new approach that applies bond percolation on random graphs to model the spread of infectious disease through heterogeneous populations. As we illustrate, these methods can be used to address public health challenges and have recently been coupled with powerful computational methods to optimize epidemic control strategies
Data-Centric Epidemic Forecasting: A Survey
The COVID-19 pandemic has brought forth the importance of epidemic
forecasting for decision makers in multiple domains, ranging from public health
to the economy as a whole. While forecasting epidemic progression is frequently
conceptualized as being analogous to weather forecasting, however it has some
key differences and remains a non-trivial task. The spread of diseases is
subject to multiple confounding factors spanning human behavior, pathogen
dynamics, weather and environmental conditions. Research interest has been
fueled by the increased availability of rich data sources capturing previously
unobservable facets and also due to initiatives from government public health
and funding agencies. This has resulted, in particular, in a spate of work on
'data-centered' solutions which have shown potential in enhancing our
forecasting capabilities by leveraging non-traditional data sources as well as
recent innovations in AI and machine learning. This survey delves into various
data-driven methodological and practical advancements and introduces a
conceptual framework to navigate through them. First, we enumerate the large
number of epidemiological datasets and novel data streams that are relevant to
epidemic forecasting, capturing various factors like symptomatic online
surveys, retail and commerce, mobility, genomics data and more. Next, we
discuss methods and modeling paradigms focusing on the recent data-driven
statistical and deep-learning based methods as well as on the novel class of
hybrid models that combine domain knowledge of mechanistic models with the
effectiveness and flexibility of statistical approaches. We also discuss
experiences and challenges that arise in real-world deployment of these
forecasting systems including decision-making informed by forecasts. Finally,
we highlight some challenges and open problems found across the forecasting
pipeline.Comment: 67 pages, 12 figure
- …