Economic evaluation of LIFE methodology

Background: The LIFE project (Lifecycle Information For E-Literature) was carried out during 2004-2006 by a consortium consisting of The British Library and University College London Library Services . The project was joint venture funded by JISC under the programme area Institutional Management Support and Collaboration. The project has received favourable feedback, for instance during a workshop organised at the end of it, and JISC has agreed to fund a second phase during 2007-2008. The consortium has been strengthened by three associate partners (SHERPA-LEAP Consortium, SHERPA-DP and the Medical Research Council). In addition some funds were reserved for the use of an outside economic consultant for an evaluation of the life-cycle models that emerged as the key results from the first phase. The LIFE-2 project consists of five work packages, and this report is part of the first of these. The objective of WP 1 is formulated in the LIFE 2 Project proposal as follows: Validation of the economic modelling and methodology for the Lifecycle and Generic Preservation formulae developed in Phase 1 of the LIFE project, with technical and presentational development of the models. Cloudlake Consulting Oy has been commissioned by the consortium to carry out this validation. The report has been written by Bo-Christer Björk. He is professor of Information Systems Science at the Swedish School of Economics and Business Administration in Helsinki, Finland. He has been conducting research concerning the scientific publishing process since 2000 and has published several peer reviewed journal articles as well as conference papers on the subject. He is often an invited speaker at international workshops in this area

Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.

BackgroundPowdery mildew, caused by the obligate biotrophic fungus Erysiphe necator, is an economically important disease of grapevines worldwide. Large quantities of fungicides are used for its control, accelerating the incidence of fungicide-resistance. Copy number variations (CNVs) are unbalanced changes in the structure of the genome that have been associated with complex traits. In addition to providing the first description of the large and highly repetitive genome of E. necator, this study describes the impact of genomic structural variation on fungicide resistance in Erysiphe necator.ResultsA shotgun approach was applied to sequence and assemble the genome of five E. necator isolates, and RNA-seq and comparative genomics were used to predict and annotate protein-coding genes. Our results show that the E. necator genome is exceptionally large and repetitive and suggest that transposable elements are responsible for genome expansion. Frequent structural variations were found between isolates and included copy number variation in EnCYP51, the target of the commonly used sterol demethylase inhibitor (DMI) fungicides. A panel of 89 additional E. necator isolates collected from diverse vineyard sites was screened for copy number variation in the EnCYP51 gene and for presence/absence of a point mutation (Y136F) known to result in higher fungicide tolerance. We show that an increase in EnCYP51 copy number is significantly more likely to be detected in isolates collected from fungicide-treated vineyards. Increased EnCYP51 copy numbers were detected with the Y136F allele, suggesting that an increase in copy number becomes advantageous only after the fungicide-tolerant allele is acquired. We also show that EnCYP51 copy number influences expression in a gene-dose dependent manner and correlates with fungal growth in the presence of a DMI fungicide.ConclusionsTaken together our results show that CNV can be adaptive in the development of resistance to fungicides by providing increasing quantitative protection in a gene-dosage dependent manner. The results of this work not only demonstrate the effectiveness of using genomics to dissect complex traits in organisms with very limited molecular information, but also may have broader implications for understanding genomic dynamics in response to strong selective pressure in other pathogens with similar genome architectures

The economics of copyright law: a stocktake of the literature

This article is a survey of publications by economists writing on copyright law. It begins with a general overview of how economists analyse these questions; the distinction is made between the economics of copying and the economic aspects of copyright law as analysed in law and economics. It then continues with sections on research on the effects of copying and downloading and the effects of unauthorised use (‘piracy’) and ends with an overall evaluation of the economics of copyright in the light of recent technological changes. Economists have always been, and still are, somewhat sceptical about copyright and question what alternatives there are to it. On balance, most accept the role of copyright law in the creative industries while urging caution about its becoming too strong. And although European authors’ rights are different in legal terms from the Anglo-American copyright, the economic analysis of these laws is essentially the same

TO PROFIT OR NOT-TO-PROFIT: AN EXAMINATION OF EXECUTIVE COMPENSATION IN NOT-FOR-PROFIT ORGANIZATIONS CONTRACTING WITH NEW YORK CITY

This report examined the compensation practices of not-for profit (NFP) organizations that have contracts with New York City.It reports the compensations statistics for NFP\u27s contracting with the city. It also reports that many of these organizations did not comply with the regulations requiring public access to NFP\u27s Annual Returns

Special features of RAD Sequencing data:implications for genotyping

Restriction site-associated DNA Sequencing (RAD-Seq) is an economical and efficient method for SNP discovery and genotyping. As with other sequencing-by-synthesis methods, RAD-Seq produces stochastic count data and requires sensitive analysis to develop or genotype markers accurately. We show that there are several sources of bias specific to RAD-Seq that are not explicitly addressed by current genotyping tools, namely restriction fragment bias, restriction site heterozygosity and PCR GC content bias. We explore the performance of existing analysis tools given these biases and discuss approaches to limiting or handling biases in RAD-Seq data. While these biases need to be taken seriously, we believe RAD loci affected by them can be excluded or processed with relative ease in most cases and that most RAD loci will be accurately genotyped by existing tools

Tools for modelling and simulating migration-based preservation

This report describes two tools for modelling and simulating the costs and risks of using IT storage systems for the long-term archiving of file-based AV assets. The tools include a model of storage costs, the ingest and access of files, the possibility of data corruption and loss from a range of mechanisms, and the impact of having limited resources with which to fulfill access requests and preservation actions. Applications include archive planning, development of a technology strategy, cost estimation for business planning, operational decision support, staff training and generally promoting awareness of the issues and challenges archives face in digital preservation