Doppler radar-based non-contact health monitoring for obstructive sleep apnea diagnosis: A comprehensive review

Today’s rapid growth of elderly populations and aging problems coupled with the prevalence of obstructive sleep apnea (OSA) and other health related issues have affected many aspects of society. This has led to high demands for a more robust healthcare monitoring, diagnosing and treatments facilities. In particular to Sleep Medicine, sleep has a key role to play in both physical and mental health. The quality and duration of sleep have a direct and significant impact on people’s learning, memory, metabolism, weight, safety, mood, cardio-vascular health, diseases, and immune system function. The gold-standard for OSA diagnosis is the overnight sleep monitoring system using polysomnography (PSG). However, despite the quality and reliability of the PSG system, it is not well suited for long-term continuous usage due to limited mobility as well as causing possible irritation, distress, and discomfort to patients during the monitoring process. These limitations have led to stronger demands for non-contact sleep monitoring systems. The aim of this paper is to provide a comprehensive review of the current state of non-contact Doppler radar sleep monitoring technology and provide an outline of current challenges and make recommendations on future research directions to practically realize and commercialize the technology for everyday usage

Near-field baseband communication system for use in biomedical implants

This thesis introduces the reader to the near-field baseband pulse radio communication for biomedical implants. It details the design and implementation of the complete communication system with a particular emphasis on the antenna structure and waveform coding that is compatible with this particular technology. The wireless communication system has great employability in small pill-sized biomedical diagnostic devices offering the advantages of low power consumption and easy integration with SoC and lab-in-a-pill technologies. The greatest challenge was the choice of antenna that had to be made to effectively transmit the pulses. A systematic approach has been carried out in arriving at the most suitable antenna for efficient emanation of pulses and the fields around it are analysed electromagnetically using a commercially available software. A magnetic antenna can be used to transmit the information from inside a human body to the outside world. The performance of the above antenna was evaluated in a salt solution of different concentrations which is similar to a highly conductive lossy medium like a human body. Near-field baseband pulse transmission is a waveform transmission scheme wherein the pulse shape is crucial for decoding information at the receiver. This demands a new approach to the antenna design, both at the transmitter and the receiver. The antenna had to be analysed in the time-domain to know its effects on the pulse and an expression for the antenna bandwidth has been proposed in this thesis. The receiving antenna should be able to detect very short pulses and while doing so has to also maintain the pulse shape with minimal distortion. Different loading congurations were explored to determine the most feasible one for receiving very short pulses. Return-to-zero (RZ), Non-return-zero (NRZ) and Manchester coded pulse waveforms were tested for their compatibility and performance with the near-field baseband pulse radio communication. It was concluded that Manchester coded waveform are perfectly suited for this particular near-field communication technology. Pulse interval modulation was also investigated and the findings suggested that it was easier to implement and had a high throughput rate too. A simple receiver algorithm has been suggested and practically tested on a digital signal processor. There is further scope for research to develop complex signal processing algorithms at the receiver

Microwave sensing for neurodegenerative diseases

The rapidly increasing rate of the ageing population has led to a higher rate in people suffering from neurodegenerative diseases. Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, are characterised by the progressive loss of brain cells, which leads to a decline in a person’s cognitive abilities, and eventually leads to death. The alarming increase in people suffering from these diseases has created a global socioeconomic burden that affects caregivers, nurses, and family members, just as much as the patient themselves. Due to the critical nature of these diseases, it is paramount that systems and devices can detect and monitor neurodegenerative diseases as early as possible, so that the right treatment can be provided to hinder its progression. Existing technologies have provided key results in the detection and monitoring of neurodegenerative diseases. However, they are limited by their bulky size, high costs, and inconvenient or invasive approach. Meanwhile, microwave sensing technology has generated promising results in several medical applications, such as cancer and stroke detection. The ability to fabricate components easily and integrate them into a wearable prototype makes microwave sensing a promising non-invasive, cost-effective, and portable or wearable solution for medical diagnostics. This work proposes the use of microwave sensing as an inexpensive, non-invasive, reliable, accurate, efficient, and wearable tool for monitoring the progression of neurodegenerative diseases. For evaluation, models were created to emulate symptoms of Alzheimer’s disease to demonstrate the technology. It is observed that microwave sensing was able to detect brain atrophy and lateral ventricle enlargement with a minimum change of 5%. In addition, microwave sensing could non-invasively detect and image regions of the brain affected by Alzheimer’s disease pathology, providing a transformational and major improvement compared to PET scans that rely on biomarkers. Moreover, microwave sensing could detect Alzheimer’s disease at one of its earliest stages: mild cognitive impairment. This work provides a promising and transformative approach for wearable and non-invasive neurodegenerative disease monitoring

Development and Experimental Analysis of Wireless High Accuracy Ultra-Wideband Localization Systems for Indoor Medical Applications

This dissertation addresses several interesting and relevant problems in the field of wireless technologies applied to medical applications and specifically problems related to ultra-wideband high accuracy localization for use in the operating room. This research is cross disciplinary in nature and fundamentally builds upon microwave engineering, software engineering, systems engineering, and biomedical engineering. A good portion of this work has been published in peer reviewed microwave engineering and biomedical engineering conferences and journals. Wireless technologies in medicine are discussed with focus on ultra-wideband positioning in orthopedic surgical navigation. Characterization of the operating room as a medium for ultra-wideband signal transmission helps define system design requirements. A discussion of the first generation positioning system provides a context for understanding the overall system architecture of the second generation ultra-wideband positioning system outlined in this dissertation. A system-level simulation framework provides a method for rapid prototyping of ultra-wideband positioning systems which takes into account all facets of the system (analog, digital, channel, experimental setup). This provides a robust framework for optimizing overall system design in realistic propagation environments. A practical approach is taken to outline the development of the second generation ultra-wideband positioning system which includes an integrated tag design and real-time dynamic tracking of multiple tags. The tag and receiver designs are outlined as well as receiver-side digital signal processing, system-level design support for multi-tag tracking, and potential error sources observed in dynamic experiments including phase center error, clock jitter and drift, and geometric position dilution of precision. An experimental analysis of the multi-tag positioning system provides insight into overall system performance including the main sources of error. A five base station experiment shows the potential of redundant base stations in improving overall dynamic accuracy. Finally, the system performance in low signal-to-noise ratio and non-line-of-sight environments is analyzed by focusing on receiver-side digitally-implemented ranging algorithms including leading-edge detection and peak detection. These technologies are aimed at use in next-generation medical systems with many applications including surgical navigation, wireless telemetry, medical asset tracking, and in vivo wireless sensors

Cyber-Human Systems, Space Technologies, and Threats

CYBER-HUMAN SYSTEMS, SPACE TECHNOLOGIES, AND THREATS is our eighth textbook in a series covering the world of UASs / CUAS/ UUVs / SPACE. Other textbooks in our series are Space Systems Emerging Technologies and Operations; Drone Delivery of CBNRECy – DEW Weapons: Emerging Threats of Mini-Weapons of Mass Destruction and Disruption (WMDD); Disruptive Technologies with applications in Airline, Marine, Defense Industries; Unmanned Vehicle Systems & Operations On Air, Sea, Land; Counter Unmanned Aircraft Systems Technologies and Operations; Unmanned Aircraft Systems in the Cyber Domain: Protecting USA’s Advanced Air Assets, 2nd edition; and Unmanned Aircraft Systems (UAS) in the Cyber Domain Protecting USA’s Advanced Air Assets, 1st edition. Our previous seven titles have received considerable global recognition in the field. (Nichols & Carter, 2022) (Nichols, et al., 2021) (Nichols R. K., et al., 2020) (Nichols R. , et al., 2020) (Nichols R. , et al., 2019) (Nichols R. K., 2018) (Nichols R. K., et al., 2022)https://newprairiepress.org/ebooks/1052/thumbnail.jp

Doctor of Philosophy

dissertationSince the late 1950s, scientists have been working toward realizing implantable devices that would directly monitor or even control the human body's internal activities. Sophisticated microsystems are used to improve our understanding of internal biological processes in animals and humans. The diversity of biomedical research dictates that microsystems must be developed and customized specifically for each new application. For advanced long-term experiments, a custom designed system-on-chip (SoC) is usually necessary to meet desired specifications. Custom SoCs, however, are often prohibitively expensive, preventing many new ideas from being explored. In this work, we have identified a set of sensors that are frequently used in biomedical research and developed a single-chip integrated microsystem that offers the most commonly used sensor interfaces, high computational power, and which requires minimum external components to operate. Included peripherals can also drive chemical reactions by setting the appropriate voltages or currents across electrodes. The SoC is highly modular and well suited for prototyping in and ex vivo experimental devices. The system runs from a primary or secondary battery that can be recharged via two inductively coupled coils. The SoC includes a 16-bit microprocessor with 32 kB of on chip SRAM. The digital core consumes 350 μW at 10 MHz and is capable of running at frequencies up to 200 MHz. The integrated microsystem has been fabricated in a 65 nm CMOS technology and the silicon has been fully tested. Integrated peripherals include two sigma-delta analog-to-digital converters, two 10-bit digital-to-analog converters, and a sleep mode timer. The system also includes a wireless ultra-wideband (UWB) transmitter. The fullydigital transmitter implementation occupies 68 x 68 μm2 of silicon area, consumes 0.72 μW static power, and achieves an energy efficiency of 19 pJ/pulse at 200 MHz pulse repetition frequency. An investigation of the suitability of the UWB technology for neural recording systems is also presented. Experimental data capturing the UWB signal transmission through an animal head are presented and a statistical model for large-scale signal fading is developed

An Implantable Microsystem for Autonomous Intraocular Pressure Monitoring .

Glaucoma, a leading cause of blindness worldwide, is a disease in which the pressure within the eye is too high for the eye to tolerate and must be reduced in order to slow or prevent damage to the optic nerve. Conventional methods for monitoring eye pressure are normally only used in the physician’s office and rely on indirect measurement methods, leading to inaccuracies. Furthermore, intraocular pressure can vary throughout the day and also depends on activity. An autonomous implantable microsystem capable of monitoring intraocular pressure with minimal patient intervention would provide useful information to the clinician in the management of glaucoma. This dissertation studies the feasibility of an integrated microsystem for autonomously measuring intraocular pressure. Small size ensures minimal impact on the patient, preventing the device from entering the field of view and simplifying implantation. Integrated haptics aid surgical implantation and minimize trauma while allowing the implant to be removed if needed. A touch-mode capacitive pressure sensor, fabricated using the dissolved wafer process, transduces intraocular pressure into capacitance with a linear response and a sensitivity of 26 fF/mmHg. A new fabrication technique has been developed to embed vertical interconnects within a glass package containing the pressure sensor, a microbattery, readout circuitry, and an antenna. This enables the vertical stacking of these components and very efficient use of limited volume. The 1.5 mm x 2 mm x 0.5 mm transparent parylene-coated glass package enables solar cells to be placed on the circuit chip for power generation, trickle charging an on-board microbattery formed using standard cleanroom materials and a non-toxic electrolyte. Flooded-cell tests verified the electrochemistry and achieved a current capacity of 8 µAh/mm2. A simple integrated readout circuit consuming 35 pW in the idle mode implemented a finite-state machine and used an optical wakeup trigger to further reduce power. The microsystem has also been demonstrated with a microprocessor to autonomously gather and store data, reading it out on demand. Finally, a pulse-based ultrawideband wireless transmission technique is proposed using non-resonant antennas. The all-digital transmitter is expected to consume much less power than conventional encoded wireless transmitters and eliminates complex circuitry.Ph.D.Electrical EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/89809/1/rhaque_1.pd

Abstracts on Radio Direction Finding (1899 - 1995)

The files on this record represent the various databases that originally composed the CD-ROM issue of "Abstracts on Radio Direction Finding" database, which is now part of the Dudley Knox Library's Abstracts and Selected Full Text Documents on Radio Direction Finding (1899 - 1995) Collection. (See Calhoun record https://calhoun.nps.edu/handle/10945/57364 for further information on this collection and the bibliography). Due to issues of technological obsolescence preventing current and future audiences from accessing the bibliography, DKL exported and converted into the three files on this record the various databases contained in the CD-ROM. The contents of these files are: 1) RDFA_CompleteBibliography_xls.zip [RDFA_CompleteBibliography.xls: Metadata for the complete bibliography, in Excel 97-2003 Workbook format; RDFA_Glossary.xls: Glossary of terms, in Excel 97-2003 Workbookformat; RDFA_Biographies.xls: Biographies of leading figures, in Excel 97-2003 Workbook format]; 2) RDFA_CompleteBibliography_csv.zip [RDFA_CompleteBibliography.TXT: Metadata for the complete bibliography, in CSV format; RDFA_Glossary.TXT: Glossary of terms, in CSV format; RDFA_Biographies.TXT: Biographies of leading figures, in CSV format]; 3) RDFA_CompleteBibliography.pdf: A human readable display of the bibliographic data, as a means of double-checking any possible deviations due to conversion

Smart Sensors for Healthcare and Medical Applications

This book focuses on new sensing technologies, measurement techniques, and their applications in medicine and healthcare. Specifically, the book briefly describes the potential of smart sensors in the aforementioned applications, collecting 24 articles selected and published in the Special Issue “Smart Sensors for Healthcare and Medical Applications”. We proposed this topic, being aware of the pivotal role that smart sensors can play in the improvement of healthcare services in both acute and chronic conditions as well as in prevention for a healthy life and active aging. The articles selected in this book cover a variety of topics related to the design, validation, and application of smart sensors to healthcare