Design of a secure architecture for the exchange of biomedical information in m-Health scenarios

El paradigma de m-Salud (salud móvil) aboga por la integración masiva de las más avanzadas tecnologías de comunicación, red móvil y sensores en aplicaciones y sistemas de salud, para fomentar el despliegue de un nuevo modelo de atención clínica centrada en el usuario/paciente. Este modelo tiene por objetivos el empoderamiento de los usuarios en la gestión de su propia salud (p.ej. aumentando sus conocimientos, promocionando estilos de vida saludable y previniendo enfermedades), la prestación de una mejor tele-asistencia sanitaria en el hogar para ancianos y pacientes crónicos y una notable disminución del gasto de los Sistemas de Salud gracias a la reducción del número y la duración de las hospitalizaciones. No obstante, estas ventajas, atribuidas a las aplicaciones de m-Salud, suelen venir acompañadas del requisito de un alto grado de disponibilidad de la información biomédica de sus usuarios para garantizar una alta calidad de servicio, p.ej. fusionar varias señales de un usuario para obtener un diagnóstico más preciso. La consecuencia negativa de cumplir esta demanda es el aumento directo de las superficies potencialmente vulnerables a ataques, lo que sitúa a la seguridad (y a la privacidad) del modelo de m-Salud como factor crítico para su éxito. Como requisito no funcional de las aplicaciones de m-Salud, la seguridad ha recibido menos atención que otros requisitos técnicos que eran más urgentes en etapas de desarrollo previas, tales como la robustez, la eficiencia, la interoperabilidad o la usabilidad. Otro factor importante que ha contribuido a retrasar la implementación de políticas de seguridad sólidas es que garantizar un determinado nivel de seguridad implica unos costes que pueden ser muy relevantes en varias dimensiones, en especial en la económica (p.ej. sobrecostes por la inclusión de hardware extra para la autenticación de usuarios), en el rendimiento (p.ej. reducción de la eficiencia y de la interoperabilidad debido a la integración de elementos de seguridad) y en la usabilidad (p.ej. configuración más complicada de dispositivos y aplicaciones de salud debido a las nuevas opciones de seguridad). Por tanto, las soluciones de seguridad que persigan satisfacer a todos los actores del contexto de m-Salud (usuarios, pacientes, personal médico, personal técnico, legisladores, fabricantes de dispositivos y equipos, etc.) deben ser robustas y al mismo tiempo minimizar sus costes asociados. Esta Tesis detalla una propuesta de seguridad, compuesta por cuatro grandes bloques interconectados, para dotar de seguridad a las arquitecturas de m-Salud con unos costes reducidos. El primer bloque define un esquema global que proporciona unos niveles de seguridad e interoperabilidad acordes con las características de las distintas aplicaciones de m-Salud. Este esquema está compuesto por tres capas diferenciadas, diseñadas a la medidas de los dominios de m-Salud y de sus restricciones, incluyendo medidas de seguridad adecuadas para la defensa contra las amenazas asociadas a sus aplicaciones de m-Salud. El segundo bloque establece la extensión de seguridad de aquellos protocolos estándar que permiten la adquisición, el intercambio y/o la administración de información biomédica -- por tanto, usados por muchas aplicaciones de m-Salud -- pero no reúnen los niveles de seguridad detallados en el esquema previo. Estas extensiones se concretan para los estándares biomédicos ISO/IEEE 11073 PHD y SCP-ECG. El tercer bloque propone nuevas formas de fortalecer la seguridad de los tests biomédicos, que constituyen el elemento esencial de muchas aplicaciones de m-Salud de carácter clínico, mediante codificaciones novedosas. Finalmente el cuarto bloque, que se sitúa en paralelo a los anteriores, selecciona herramientas genéricas de seguridad (elementos de autenticación y criptográficos) cuya integración en los otros bloques resulta idónea, y desarrolla nuevas herramientas de seguridad, basadas en señal -- embedding y keytagging --, para reforzar la protección de los test biomédicos.The paradigm of m-Health (mobile health) advocates for the massive integration of advanced mobile communications, network and sensor technologies in healthcare applications and systems to foster the deployment of a new, user/patient-centered healthcare model enabling the empowerment of users in the management of their health (e.g. by increasing their health literacy, promoting healthy lifestyles and the prevention of diseases), a better home-based healthcare delivery for elderly and chronic patients and important savings for healthcare systems due to the reduction of hospitalizations in number and duration. It is a fact that many m-Health applications demand high availability of biomedical information from their users (for further accurate analysis, e.g. by fusion of various signals) to guarantee high quality of service, which on the other hand entails increasing the potential surfaces for attacks. Therefore, it is not surprising that security (and privacy) is commonly included among the most important barriers for the success of m-Health. As a non-functional requirement for m-Health applications, security has received less attention than other technical issues that were more pressing at earlier development stages, such as reliability, eficiency, interoperability or usability. Another fact that has contributed to delaying the enforcement of robust security policies is that guaranteeing a certain security level implies costs that can be very relevant and that span along diferent dimensions. These include budgeting (e.g. the demand of extra hardware for user authentication), performance (e.g. lower eficiency and interoperability due to the addition of security elements) and usability (e.g. cumbersome configuration of devices and applications due to security options). Therefore, security solutions that aim to satisfy all the stakeholders in the m-Health context (users/patients, medical staff, technical staff, systems and devices manufacturers, regulators, etc.) shall be robust and, at the same time, minimize their associated costs. This Thesis details a proposal, composed of four interrelated blocks, to integrate appropriate levels of security in m-Health architectures in a cost-efcient manner. The first block designes a global scheme that provides different security and interoperability levels accordingto how critical are the m-Health applications to be implemented. This consists ofthree layers tailored to the m-Health domains and their constraints, whose security countermeasures defend against the threats of their associated m-Health applications. Next, the second block addresses the security extension of those standard protocols that enable the acquisition, exchange and/or management of biomedical information | thus, used by many m-Health applications | but do not meet the security levels described in the former scheme. These extensions are materialized for the biomedical standards ISO/IEEE 11073 PHD and SCP-ECG. Then, the third block proposes new ways of enhancing the security of biomedical standards, which are the centerpiece of many clinical m-Health applications, by means of novel codings. Finally the fourth block, with is parallel to the others, selects generic security methods (for user authentication and cryptographic protection) whose integration in the other blocks results optimal, and also develops novel signal-based methods (embedding and keytagging) for strengthening the security of biomedical tests. The layer-based extensions of the standards ISO/IEEE 11073 PHD and SCP-ECG can be considered as robust, cost-eficient and respectful with their original features and contents. The former adds no attributes to its data information model, four new frames to the service model |and extends four with new sub-frames|, and only one new sub-state to the communication model. Furthermore, a lightweight architecture consisting of a personal health device mounting a 9 MHz processor and an aggregator mounting a 1 GHz processor is enough to transmit a 3-lead electrocardiogram in real-time implementing the top security layer. The extra requirements associated to this extension are an initial configuration of the health device and the aggregator, tokens for identification/authentication of users if these devices are to be shared and the implementation of certain IHE profiles in the aggregator to enable the integration of measurements in healthcare systems. As regards to the extension of SCP-ECG, it only adds a new section with selected security elements and syntax in order to protect the rest of file contents and provide proper role-based access control. The overhead introduced in the protected SCP-ECG is typically 2{13 % of the regular file size, and the extra delays to protect a newly generated SCP-ECG file and to access it for interpretation are respectively a 2{10 % and a 5 % of the regular delays. As regards to the signal-based security techniques developed, the embedding method is the basis for the proposal of a generic coding for tests composed of biomedical signals, periodic measurements and contextual information. This has been adjusted and evaluated with electrocardiogram and electroencephalogram-based tests, proving the objective clinical quality of the coded tests, the capacity of the coding-access system to operate in real-time (overall delays of 2 s for electrocardiograms and 3.3 s for electroencephalograms) and its high usability. Despite of the embedding of security and metadata to enable m-Health services, the compression ratios obtained by this coding range from ' 3 in real-time transmission to ' 5 in offline operation. Complementarily, keytagging permits associating information to images (and other signals) by means of keys in a secure and non-distorting fashion, which has been availed to implement security measures such as image authentication, integrity control and location of tampered areas, private captioning with role-based access control, traceability and copyright protection. The tests conducted indicate a remarkable robustness-capacity tradeoff that permits implementing all this measures simultaneously, and the compatibility of keytagging with JPEG2000 compression, maintaining this tradeoff while setting the overall keytagging delay in only ' 120 ms for any image size | evidencing the scalability of this technique. As a general conclusion, it has been demonstrated and illustrated with examples that there are various, complementary and structured manners to contribute in the implementation of suitable security levels for m-Health architectures with a moderate cost in budget, performance, interoperability and usability. The m-Health landscape is evolving permanently along all their dimensions, and this Thesis aims to do so with its security. Furthermore, the lessons learned herein may offer further guidance for the elaboration of more comprehensive and updated security schemes, for the extension of other biomedical standards featuring low emphasis on security or privacy, and for the improvement of the state of the art regarding signal-based protection methods and applications

Recent Advances in Signal Processing

The signal processing task is a very critical issue in the majority of new technological inventions and challenges in a variety of applications in both science and engineering fields. Classical signal processing techniques have largely worked with mathematical models that are linear, local, stationary, and Gaussian. They have always favored closed-form tractability over real-world accuracy. These constraints were imposed by the lack of powerful computing tools. During the last few decades, signal processing theories, developments, and applications have matured rapidly and now include tools from many areas of mathematics, computer science, physics, and engineering. This book is targeted primarily toward both students and researchers who want to be exposed to a wide variety of signal processing techniques and algorithms. It includes 27 chapters that can be categorized into five different areas depending on the application at hand. These five categories are ordered to address image processing, speech processing, communication systems, time-series analysis, and educational packages respectively. The book has the advantage of providing a collection of applications that are completely independent and self-contained; thus, the interested reader can choose any chapter and skip to another without losing continuity

Optimal Resource Allocation Using Deep Learning-Based Adaptive Compression For Mhealth Applications

In the last few years the number of patients with chronic diseases that require constant monitoring increases rapidly; which motivates the researchers to develop scalable remote health applications. Nevertheless, transmitting big real-time data through a dynamic network limited by the bandwidth, end-to-end delay and transmission energy; will be an obstacle against having an efficient transmission of the data. The problem can be resolved by applying data reduction techniques on the vital signs at the transmitter side and reconstructing the data at the receiver side (i.e. the m-Health center). However, a new problem will be introduced which is the ability to receive the vital signs at the server side with an acceptable distortion rate (i.e. deformation of vital signs because of inefficient data reduction). In this thesis, we integrate efficient data reduction with wireless networking to deliver an adaptive compression with an acceptable distortion, while reacting to the wireless network dynamics such as channel fading and user mobility. A Deep Learning (DL) approach was used to implement an adaptive compression technique to compress and reconstruct the vital signs in general and specifically the Electroencephalogram Signal (EEG) with the minimum distortion. Then, a resource allocation framework was introduced to minimize the transmission energy along with the distortion of the reconstructed signa

Lossless and low-cost integer-based lifting wavelet transform

Discrete wavelet transform (DWT) is a powerful tool for analyzing real-time signals, including aperiodic, irregular, noisy, and transient data, because of its capability to explore signals in both the frequency- and time-domain in different resolutions. For this reason, they are used extensively in a wide number of applications in image and signal processing. Despite the wide usage, the implementation of the wavelet transform is usually lossy or computationally complex, and it requires expensive hardware. However, in many applications, such as medical diagnosis, reversible data-hiding, and critical satellite data, lossless implementation of the wavelet transform is desirable. It is also important to have more hardware-friendly implementations due to its recent inclusion in signal processing modules in system-on-chips (SoCs). To address the need, this research work provides a generalized implementation of a wavelet transform using an integer-based lifting method to produce lossless and low-cost architecture while maintaining the performance close to the original wavelets. In order to achieve a general implementation method for all orthogonal and biorthogonal wavelets, the Daubechies wavelet family has been utilized at first since it is one of the most widely used wavelets and based on a systematic method of construction of compact support orthogonal wavelets. Though the first two phases of this work are for Daubechies wavelets, they can be generalized in order to apply to other wavelets as well. Subsequently, some techniques used in the primary works have been adopted and the critical issues for achieving general lossless implementation have solved to propose a general lossless method. The research work presented here can be divided into several phases. In the first phase, low-cost architectures of the Daubechies-4 (D4) and Daubechies-6 (D6) wavelets have been derived by applying the integer-polynomial mapping. A lifting architecture has been used which reduces the cost by a half compared to the conventional convolution-based approach. The application of integer-polynomial mapping (IPM) of the polynomial filter coefficient with a floating-point value further decreases the complexity and reduces the loss in signal reconstruction. Also, the “resource sharing” between lifting steps results in a further reduction in implementation costs and near-lossless data reconstruction. In the second phase, a completely lossless or error-free architecture has been proposed for the Daubechies-8 (D8) wavelet. Several lifting variants have been derived for the same wavelet, the integer mapping has been applied, and the best variant is determined in terms of performance, using entropy and transform coding gain. Then a theory has been derived regarding the impact of scaling steps on the transform coding gain (GT). The approach results in the lowest cost lossless architecture of the D8 in the literature, to the best of our knowledge. The proposed approach may be applied to other orthogonal wavelets, including biorthogonal ones to achieve higher performance. In the final phase, a general algorithm has been proposed to implement the original filter coefficients expressed by a polyphase matrix into a more efficient lifting structure. This is done by using modified factorization, so that the factorized polyphase matrix does not include the lossy scaling step like the conventional lifting method. This general technique has been applied on some widely used orthogonal and biorthogonal wavelets and its advantages have been discussed. Since the discrete wavelet transform is used in a vast number of applications, the proposed algorithms can be utilized in those cases to achieve lossless, low-cost, and hardware-friendly architectures

Compressive Sensing with Low-Power Transfer and Accurate Reconstruction of EEG Signals

Tele-monitoring of EEG in WBAN is essential as EEG is the most powerful physiological parameters to diagnose any neurological disorder. Generally, EEG signal needs to record for longer periods which results in a large volume of data leading to huge storage and communication bandwidth requirements in WBAN. Moreover, WBAN sensor nodes are battery operated which consumes lots of energy. The aim of this research is, therefore, low power transmission of EEG signal over WBAN and its accurate reconstruction at the receiver to enable continuous online-monitoring of EEG and real time feedback to the patients from the medical experts. To reduce data rate and consequently reduce power consumption, compressive sensing (CS) may be employed prior to transmission. Nonetheless, for EEG signals, the accuracy of reconstruction of the signal with CS depends on a suitable dictionary in which the signal is sparse. As the EEG signal is not sparse in either time or frequency domain, identifying an appropriate dictionary is paramount. There are a plethora of choices for the dictionary to be used. Wavelet bases are of interest due to the availability of associated systems and methods. However, the attributes of wavelet bases that can lead to good quality of reconstruction are not well understood. For the first time in this study, it is demonstrated that in selecting wavelet dictionaries, the incoherence with the sensing matrix and the number of vanishing moments of the dictionary should be considered at the same time. In this research, a framework is proposed for the selection of an appropriate wavelet dictionary for EEG signal which is used in tandem with sparse binary matrix (SBM) as the sensing matrix and ST-SBL method as the reconstruction algorithm. Beylkin (highly incoherent with SBM and relatively high number of vanishing moments) is identified as the best dictionary to be used amongst the dictionaries are evaluated in this thesis. The power requirements for the proposed framework are also quantified using a power model. The outcomes will assist to realize the computational complexity and online implementation requirements of CS for transmitting EEG in WBAN. The proposed approach facilitates the energy savings budget well into the microwatts range, ensuring a significant savings of battery life and overall system’s power. The study is intended to create a strong base for the use of EEG in the high-accuracy and low-power based biomedical applications in WBAN

Kajian motivasi ekstrinsik di antara Pelajar Lepasan Sijil dan Diploma Politeknik Jabatan Kejuruteraan Awam KUiTTHO

Kajian ini dijalankan untuk menyelidiki pengaruh dorongan keluarga, cara pengajaran pensyarah, pengaruh rakan sebaya dan kemudahan infrastruktur terhadap motivasi ekstrinsik bagi pelajar tahun tiga dan tahun empat lepasan sijil dan diploma politeknik Jabatan Kejuruteraan Awain Kolej Universiti Teknologi Tun Hussein Onn. Sampel kajian ini beijumlah 87 orang bagi pelajar lepasan sijil politeknik dan 38 orang bagi lepasan diploma politeknik. Data kajian telah diperolehi melalui borang soal selidik dan telah dianalisis menggunakan perisian SPSS (Statical Package For Sciences). Hasil kajian telah dipersembahkan dalam bentuk jadual dan histohgrapi. Analisis kajian mendapati bahawa kedua-dua kumpulan setuju bahawa faktor-faktor di atas memberi kesan kepada motivasi ekstrinsik mereka. Dengan kata lain faktpr-faktor tersebut penting dalam membentuk pelajar mencapai kecemerlangan akademik

An Analysis of Compressive Convolutional Autoencoders for Image Archiving In Medical Informatics

Within a given enterprise network, an array of data types needs to be communicated. These network transmissions consist of images, videos, text, and binaries that have unique requirements of bandwidth and computational overhead to transmit. With respect to medical informatics, these include a multitude of varying subjects, standards, and modalities which are communicated to and from imaging equipment, clinicians, and medical archives. To reduce the required bandwidth to transmit, or provide adequate storage capacity for archival purposes, the data may be compressed in such a way that reduces the size of the image when it is transferred or stored. The original data may be reconstructed either completely or to an acceptable degree of completeness using lossy or lossless compression strategies. The scope of this inquiry is to define ways in which convolutional compressive autoencoders may be used for lossy compression. Multiple approaches will be identified and introduced to define their respective optimal datasets, along with their tuned hyperparameters

A Flexible Fuzzy Regression Method for Addressing Nonlinear Uncertainty on Aesthetic Quality Assessments

Development of new products or services requires knowledge and understanding of aesthetic qualities that correlate to perceptual pleasure. As it is not practical to develop a survey to assess aesthetic quality for all objective features of a new product or service, it is necessary to develop a model to predict aesthetic qualities. In this paper, a fuzzy regression method is proposed to predict aesthetic quality from a given set of objective features and to account for uncertainty in human assessment. The proposed method overcomes the shortcoming of statistical regression, which can predict only quality magnitudes but cannot predict quality uncertainty. The proposed method also attempts to improve traditional fuzzy regressions, which simulate a single characteristic with which the estimated uncertainty can only increase with the increasing magnitudes of objective features. The proposed fuzzy regression method uses genetic programming to develop nonlinear structures of the models, and model coefficients are determined by optimizing the fuzzy criteria. Hence, the developed model can be used to fit the nonlinearities of sample magnitudes and uncertainties. The effectiveness and the performance of the proposed method are evaluated by the case study of perceptual images, which are involved with different sampling natures and with different amounts of samples. This case study attempts to address different characteristics of human assessments. The outcomes demonstrate that more robust models can be developed by the proposed fuzzy regression method compared with the recently developed fuzzy regression methods, when the model characteristics and fuzzy criteria are taken into account