2,287 research outputs found

    Review of flexible energy harvesting for bioengineering in alignment with SDG

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    To cater to the extensive body movements and deformations necessitated by biomedical equipment flexible piezoelectrics emerge as a promising solution for energy harvesting. This review research delves into the potential of Flexible Piezoelectric Materials (FPM) as a sustainable solution for clean and affordable energy, aligning with the United Nations' Sustainable Development Goals (SDGs). By systematically examining the secondary functions of stretchability, hybrid energy harvesting, and self-healing, the study aims to comprehensively understand these materials' mechanisms, strategies, and relationships between structural characteristics and properties. The research highlights the significance of designing piezoelectric materials that can conform to the curvilinear shape of the human body, enabling sustainable and efficient mechanical energy capture for various applications, such as biosensors and actuators. The study identifies critical areas for future investigation, including the commercialization of stretchable piezoelectric systems, prevention of unintended interference in hybrid energy harvesters, development of consistent wearability metrics, and enhancement of the elastic piezoelectric material, electrode circuit, and substrate for improved stretchability and comfort. In conclusion, this review research offers valuable insights into developing and implementing FPM as a promising and innovative approach to harnessing clean, affordable energy in line with the SDGs.</p

    Review of flexible energy harvesting for bioengineering in alignment with SDG

    Get PDF
    To cater to the extensive body movements and deformations necessitated by biomedical equipment flexible piezoelectrics emerge as a promising solution for energy harvesting. This review research delves into the potential of Flexible Piezoelectric Materials (FPM) as a sustainable solution for clean and affordable energy, aligning with the United Nations' Sustainable Development Goals (SDGs). By systematically examining the secondary functions of stretchability, hybrid energy harvesting, and self-healing, the study aims to comprehensively understand these materials' mechanisms, strategies, and relationships between structural characteristics and properties. The research highlights the significance of designing piezoelectric materials that can conform to the curvilinear shape of the human body, enabling sustainable and efficient mechanical energy capture for various applications, such as biosensors and actuators. The study identifies critical areas for future investigation, including the commercialization of stretchable piezoelectric systems, prevention of unintended interference in hybrid energy harvesters, development of consistent wearability metrics, and enhancement of the elastic piezoelectric material, electrode circuit, and substrate for improved stretchability and comfort. In conclusion, this review research offers valuable insights into developing and implementing FPM as a promising and innovative approach to harnessing clean, affordable energy in line with the SDGs.</p

    Neuromorphic hardware for somatosensory neuroprostheses

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    In individuals with sensory-motor impairments, missing limb functions can be restored using neuroprosthetic devices that directly interface with the nervous system. However, restoring the natural tactile experience through electrical neural stimulation requires complex encoding strategies. Indeed, they are presently limited in effectively conveying or restoring tactile sensations by bandwidth constraints. Neuromorphic technology, which mimics the natural behavior of neurons and synapses, holds promise for replicating the encoding of natural touch, potentially informing neurostimulation design. In this perspective, we propose that incorporating neuromorphic technologies into neuroprostheses could be an effective approach for developing more natural human-machine interfaces, potentially leading to advancements in device performance, acceptability, and embeddability. We also highlight ongoing challenges and the required actions to facilitate the future integration of these advanced technologies

    The Sound of Bass Culture(s): Heaviness, Blackness, and Ubiquitous Bass

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    Bass culture describes the shared affinity for excessive low frequency aesthetics. During the 2000s and 2010s, discussion of the term first emerged within the context of bass-centric Afrodiasporic popular music genres such as hip-hop, EDM, dancehall, and reggaeton. In this thesis, I theorize sonic elements of bass prominence through the concept of heaviness—a multidimensional timbral definition that extends beyond mere prescriptions of lowness and loudness. Historicizing bass centricity, I discuss Jamaican music during the 1950s and ‘60s where sound system practices contributed to the codification of bass as a sign of Blackness. Looking to the future, I present the concept of ubiquitous bass—the omnipresence of low-end frequencies now available in the latest developments of portable listening devices. Though a case study of Beats headphones, I argue that increased accessibility of heavy bass in virtual experiences marks a significant shift from established accounts of low-end theory

    LIPIcs, Volume 251, ITCS 2023, Complete Volume

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    LIPIcs, Volume 251, ITCS 2023, Complete Volum

    Advanced Filter Solutions for High-performance Millimetre and Submillimetre-wave Systems

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    This thesis is devoted to the investigation of advanced filter design solutions for high-performance millimetre and submillimetre-wave systems. Each of the proposed design solutions are enabled using waveguide-based technologies with the aim of advancing future generations of satellite communications, radar, and remote sensing. As trends for frequency allocations move to higher and higher frequency bands, engineers are faced with increasingly complex challenges such as the degradation of component performance, the inability to correctively tune the performance, or scenarios that all together make circuits infeasible. In light of these challenges, this work seeks to advance the current literature on filter design and proposes many unique design solutions for overcoming manufacturing and accuracy limitations, reducing the transmission losses, and reducing the overall design complexity. Each of the proposed filter solutions that are presented in this thesis are based on either a novel structural design or a novel technology. Each of the proposed designs are presented with functional prototypes as a means of verifying the theory. In the majority of cases, prototypes have been manufactured using high-precision computer numerical control (CNC) milling, and in several articles, exploratory activities with the use of alternative technologies such as stereolithography (SLA) 3D-printing and deep-reactive ion etching (DRIE) are presented. Prior to the presentation of the filter designs, an overview on the design and synthesis of millimetre-wave filters and diplexers is provided and serves as a foundation for the coupling matrix descriptions of symmetric and asymmetric resonator designs throughout this work

    Low-Overhead Online Assessment of Timely Progress as a System Commodity

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    ENGINEERING HIGH-RESOLUTION EXPERIMENTAL AND COMPUTATIONAL PIPELINES TO CHARACTERIZE HUMAN GASTROINTESTINAL TISSUES IN HEALTH AND DISEASE

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    In recent decades, new high-resolution technologies have transformed how scientists study complex cellular processes and the mechanisms responsible for maintaining homeostasis and the emergence and progression of gastrointestinal (GI) disease. These advances have paved the way for the use of primary human cells in experimental models which together can mimic specific aspects of the GI tract such as compartmentalized stem-cell zones, gradients of growth factors, and shear stress from fluid flow. The work presented in this dissertation has focused on integrating high-resolution bioinformatics with novel experimental models of the GI epithelium systems to describe the complexity of human pathophysiology of the human small intestines, colon, and stomach in homeostasis and disease. Here, I used three novel microphysiological systems and developed four computational pipelines to describe comprehensive gene expression patterns of the GI epithelium in various states of health and disease. First, I used single cell RNAseq (scRNAseq) to establish the transcriptomic landscape of the entire epithelium of the small intestine and colon from three human donors, describing cell-type specific gene expression patterns in high resolution. Second, I used single cell and bulk RNAseq to model intestinal absorption of fatty acids and show that fatty acid oxidation is a critical regulator of the flux of long- and medium-chain fatty acids across the epithelium. Third, I use bulk RNAseq and a machine learning model to describe how inflammatory cytokines can regulate proliferation of intestinal stem cells in an experimental model of inflammatory hypoxia. Finally, I developed a high throughput platform that can associate phenotype to gene expression in clonal organoids, providing unprecedented resolution into the relationship between comprehensive gene expression patterns and their accompanying phenotypic effects. Through these studies, I have demonstrated how the integration of computational and experimental approaches can measurably advance our understanding of human GI physiology.Doctor of Philosoph
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